Human granulocytic anaplasmosis combined with rhabdomyolysis: a case report

Abstract Background Human granulocytic anaplasmosis (HGA) is a systemic inflammatory response caused by the rickettsial bacterium Anaplasma phagocytophilum. Rhabdomyolysis and acute kidney injury (AKI) are rare complications of HGA. Here, we report a case of HGA concurrent with rhabdomyolysis and AK...

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Autores principales:	Jeong Min Cho, Jeonghyun Chang, Dong-Min Kim, Yee Gyung Kwak, Chong Rae Cho, Je Eun Song
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Human granulocytic anaplasmosis Rhabdomyolysis Tick-borne diseases Anaplasma phagocytophilum Case report Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/2679fdecd9bc4088b1411f4b7766354e
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spelling	oai:doaj.org-article:2679fdecd9bc4088b1411f4b7766354e2021-11-28T12:41:47ZHuman granulocytic anaplasmosis combined with rhabdomyolysis: a case report10.1186/s12879-021-06869-z1471-2334https://doaj.org/article/2679fdecd9bc4088b1411f4b7766354e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06869-zhttps://doaj.org/toc/1471-2334Abstract Background Human granulocytic anaplasmosis (HGA) is a systemic inflammatory response caused by the rickettsial bacterium Anaplasma phagocytophilum. Rhabdomyolysis and acute kidney injury (AKI) are rare complications of HGA. Here, we report a case of HGA concurrent with rhabdomyolysis and AKI in an elderly patient. Case presentation An 84-year old woman with a medical history of hypertension was hospitalised after two days of fever, dizziness, whole body pain, and general weakness. Laboratory investigations showed severe thrombocytopenia, leukopenia, impaired renal function, and elevated cardiac enzyme and myoglobin levels. On the day after admission, peripheral blood smear revealed morula inclusions in neutrophils, a suggestive finding of HGA. Real-time polymerase chain reaction (PCR) results indicated the presence of A. phagocytophilum. Antibiotics were de-escalated to doxycycline monotherapy. After 10 days of antibiotic treatment, laboratory tests showed complete recovery from HGA complicated with rhabdomyolysis and AKI. Conclusions HGA can lead to serious complications in patients with associated risk factors. Therefore, in patients with HGA accompanied by rhabdomyolysis, management with antibiotics and hydration should be initiated immediately, and not delayed until diagnostic confirmation.Jeong Min ChoJeonghyun ChangDong-Min KimYee Gyung KwakChong Rae ChoJe Eun SongBMCarticleHuman granulocytic anaplasmosisRhabdomyolysisTick-borne diseasesAnaplasma phagocytophilumCase reportInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Human granulocytic anaplasmosis Rhabdomyolysis Tick-borne diseases Anaplasma phagocytophilum Case report Infectious and parasitic diseases RC109-216
spellingShingle	Human granulocytic anaplasmosis Rhabdomyolysis Tick-borne diseases Anaplasma phagocytophilum Case report Infectious and parasitic diseases RC109-216 Jeong Min Cho Jeonghyun Chang Dong-Min Kim Yee Gyung Kwak Chong Rae Cho Je Eun Song Human granulocytic anaplasmosis combined with rhabdomyolysis: a case report
description	Abstract Background Human granulocytic anaplasmosis (HGA) is a systemic inflammatory response caused by the rickettsial bacterium Anaplasma phagocytophilum. Rhabdomyolysis and acute kidney injury (AKI) are rare complications of HGA. Here, we report a case of HGA concurrent with rhabdomyolysis and AKI in an elderly patient. Case presentation An 84-year old woman with a medical history of hypertension was hospitalised after two days of fever, dizziness, whole body pain, and general weakness. Laboratory investigations showed severe thrombocytopenia, leukopenia, impaired renal function, and elevated cardiac enzyme and myoglobin levels. On the day after admission, peripheral blood smear revealed morula inclusions in neutrophils, a suggestive finding of HGA. Real-time polymerase chain reaction (PCR) results indicated the presence of A. phagocytophilum. Antibiotics were de-escalated to doxycycline monotherapy. After 10 days of antibiotic treatment, laboratory tests showed complete recovery from HGA complicated with rhabdomyolysis and AKI. Conclusions HGA can lead to serious complications in patients with associated risk factors. Therefore, in patients with HGA accompanied by rhabdomyolysis, management with antibiotics and hydration should be initiated immediately, and not delayed until diagnostic confirmation.
format	article
author	Jeong Min Cho Jeonghyun Chang Dong-Min Kim Yee Gyung Kwak Chong Rae Cho Je Eun Song
author_facet	Jeong Min Cho Jeonghyun Chang Dong-Min Kim Yee Gyung Kwak Chong Rae Cho Je Eun Song
author_sort	Jeong Min Cho
title	Human granulocytic anaplasmosis combined with rhabdomyolysis: a case report
title_short	Human granulocytic anaplasmosis combined with rhabdomyolysis: a case report
title_full	Human granulocytic anaplasmosis combined with rhabdomyolysis: a case report
title_fullStr	Human granulocytic anaplasmosis combined with rhabdomyolysis: a case report
title_full_unstemmed	Human granulocytic anaplasmosis combined with rhabdomyolysis: a case report
title_sort	human granulocytic anaplasmosis combined with rhabdomyolysis: a case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/2679fdecd9bc4088b1411f4b7766354e
work_keys_str_mv	AT jeongmincho humangranulocyticanaplasmosiscombinedwithrhabdomyolysisacasereport AT jeonghyunchang humangranulocyticanaplasmosiscombinedwithrhabdomyolysisacasereport AT dongminkim humangranulocyticanaplasmosiscombinedwithrhabdomyolysisacasereport AT yeegyungkwak humangranulocyticanaplasmosiscombinedwithrhabdomyolysisacasereport AT chongraecho humangranulocyticanaplasmosiscombinedwithrhabdomyolysisacasereport AT jeeunsong humangranulocyticanaplasmosiscombinedwithrhabdomyolysisacasereport
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Human granulocytic anaplasmosis combined with rhabdomyolysis: a case report

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