NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle

Lysine fatty acylation is an important protein posttranslational modification but mammalian lysine fatty acyl transferases have remained unknown so far. Here the authors report that the human N-terminal glycine myristoyltransferases 1 and 2 catalyze the addition of myristoyl chains to specific lysin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tatsiana Kosciuk, Ian R. Price, Xiaoyu Zhang, Chengliang Zhu, Kayla N. Johnson, Shuai Zhang, Steve L. Halaby, Garrison P. Komaniecki, Min Yang, Caroline J. DeHart, Paul M. Thomas, Neil L. Kelleher, J. Christopher Fromme, Hening Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2680a250e1e54ba7aecb1d6f4993fea7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2680a250e1e54ba7aecb1d6f4993fea7
record_format	dspace
spelling	oai:doaj.org-article:2680a250e1e54ba7aecb1d6f4993fea72021-12-02T15:34:13ZNMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle10.1038/s41467-020-14893-x2041-1723https://doaj.org/article/2680a250e1e54ba7aecb1d6f4993fea72020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14893-xhttps://doaj.org/toc/2041-1723Lysine fatty acylation is an important protein posttranslational modification but mammalian lysine fatty acyl transferases have remained unknown so far. Here the authors report that the human N-terminal glycine myristoyltransferases 1 and 2 catalyze the addition of myristoyl chains to specific lysine residues and show that they myristoylate ARF6 lysine 3, which explains the unusual membrane binding properties of ARF6.Tatsiana KosciukIan R. PriceXiaoyu ZhangChengliang ZhuKayla N. JohnsonShuai ZhangSteve L. HalabyGarrison P. KomanieckiMin YangCaroline J. DeHartPaul M. ThomasNeil L. KelleherJ. Christopher FrommeHening LinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tatsiana Kosciuk Ian R. Price Xiaoyu Zhang Chengliang Zhu Kayla N. Johnson Shuai Zhang Steve L. Halaby Garrison P. Komaniecki Min Yang Caroline J. DeHart Paul M. Thomas Neil L. Kelleher J. Christopher Fromme Hening Lin NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle
description	Lysine fatty acylation is an important protein posttranslational modification but mammalian lysine fatty acyl transferases have remained unknown so far. Here the authors report that the human N-terminal glycine myristoyltransferases 1 and 2 catalyze the addition of myristoyl chains to specific lysine residues and show that they myristoylate ARF6 lysine 3, which explains the unusual membrane binding properties of ARF6.
format	article
author	Tatsiana Kosciuk Ian R. Price Xiaoyu Zhang Chengliang Zhu Kayla N. Johnson Shuai Zhang Steve L. Halaby Garrison P. Komaniecki Min Yang Caroline J. DeHart Paul M. Thomas Neil L. Kelleher J. Christopher Fromme Hening Lin
author_facet	Tatsiana Kosciuk Ian R. Price Xiaoyu Zhang Chengliang Zhu Kayla N. Johnson Shuai Zhang Steve L. Halaby Garrison P. Komaniecki Min Yang Caroline J. DeHart Paul M. Thomas Neil L. Kelleher J. Christopher Fromme Hening Lin
author_sort	Tatsiana Kosciuk
title	NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle
title_short	NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle
title_full	NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle
title_fullStr	NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle
title_full_unstemmed	NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle
title_sort	nmt1 and nmt2 are lysine myristoyltransferases regulating the arf6 gtpase cycle
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2680a250e1e54ba7aecb1d6f4993fea7
work_keys_str_mv	AT tatsianakosciuk nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle AT ianrprice nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle AT xiaoyuzhang nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle AT chengliangzhu nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle AT kaylanjohnson nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle AT shuaizhang nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle AT stevelhalaby nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle AT garrisonpkomaniecki nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle AT minyang nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle AT carolinejdehart nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle AT paulmthomas nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle AT neillkelleher nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle AT jchristopherfromme nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle AT heninglin nmt1andnmt2arelysinemyristoyltransferasesregulatingthearf6gtpasecycle
_version_	1718386887621607424

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle

Ejemplares similares