Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV.

<h4>Background</h4>The life expectancy of people living with HIV (PLWH) remains shorter than that of the general population, despite significant improvement in the recent years. Mortality in HIV-infected individuals may be associated with a higher viral load at of diagnosis, a lower CD4...

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Autores principales:	Bogusz Jan Aksak-Wąs, Miłosz Parczewski, Anna Urbańska, Małgorzata Hackiewicz, Justyna D Kowalska
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2680cbe99157415383d749e64dff8905
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spelling	oai:doaj.org-article:2680cbe99157415383d749e64dff89052021-12-02T20:18:29ZInfluence of HLA-B5701 on 20 year survival rate among patients living with HIV.1932-620310.1371/journal.pone.0255834https://doaj.org/article/2680cbe99157415383d749e64dff89052021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255834https://doaj.org/toc/1932-6203<h4>Background</h4>The life expectancy of people living with HIV (PLWH) remains shorter than that of the general population, despite significant improvement in the recent years. Mortality in HIV-infected individuals may be associated with a higher viral load at of diagnosis, a lower CD4 count, or clinical variables such as sex or route of transmission. This article investigated the role of the HLA-B5701 varian on mortality among PLWH.<h4>Methods</h4>Material for the analysis consist of the data of 2,393 patients for whom the HLA-B57 variant was known. Those patients were followed under the care of the Infectious Diseases Hospital in Warsaw (n = 1555) and the Clinic of Acquired Immunodeficiency of the Pomeranian Medical University in Szczecin (n = 838). Factors such as age, gender, date of HIV diagnosis, route of transmission, date of death, baseline HIV viral load and baseline CD4 counts, were collected, and end-point cross-sectional analyses were marked at 60, 120, 180 and 240 month of observation.<h4>Results</h4>HLA-B5701 allele was found in 133 (5.5%) analyzed cases. Median age was notably higher for HLA-B5701 positive patients [32.7 (28.3-41.3) vs. 31.6 (26.8-38.3)years p = 0.02]. HLA-B5701 was associated with lower baseline viral load [4.21 (3.5-4.8) vs. 4.79 (4.2-5.3)log copies/ml p<0.001] and higher CD4count [448 (294.5-662) vs. 352 (176-514) cells/μl p<0.001]. There were no association between HLA-B5701 and survival for any given end-point. Higher mortality was associated to male gender, intravenous drug users, lower CD4 count at baseline and higher baseline viral load.<h4>Conclusions</h4>In our study, the presence of HLA-B5701 allel was not associated with mortality rate of HIV infected patients, irrespective of being associated with both higher baseline CD4 + cell count and lower baseline HIV viral load.Bogusz Jan Aksak-WąsMiłosz ParczewskiAnna UrbańskaMałgorzata HackiewiczJustyna D KowalskaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255834 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bogusz Jan Aksak-Wąs Miłosz Parczewski Anna Urbańska Małgorzata Hackiewicz Justyna D Kowalska Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV.
description	<h4>Background</h4>The life expectancy of people living with HIV (PLWH) remains shorter than that of the general population, despite significant improvement in the recent years. Mortality in HIV-infected individuals may be associated with a higher viral load at of diagnosis, a lower CD4 count, or clinical variables such as sex or route of transmission. This article investigated the role of the HLA-B5701 varian on mortality among PLWH.<h4>Methods</h4>Material for the analysis consist of the data of 2,393 patients for whom the HLA-B57 variant was known. Those patients were followed under the care of the Infectious Diseases Hospital in Warsaw (n = 1555) and the Clinic of Acquired Immunodeficiency of the Pomeranian Medical University in Szczecin (n = 838). Factors such as age, gender, date of HIV diagnosis, route of transmission, date of death, baseline HIV viral load and baseline CD4 counts, were collected, and end-point cross-sectional analyses were marked at 60, 120, 180 and 240 month of observation.<h4>Results</h4>HLA-B5701 allele was found in 133 (5.5%) analyzed cases. Median age was notably higher for HLA-B5701 positive patients [32.7 (28.3-41.3) vs. 31.6 (26.8-38.3)years p = 0.02]. HLA-B5701 was associated with lower baseline viral load [4.21 (3.5-4.8) vs. 4.79 (4.2-5.3)log copies/ml p<0.001] and higher CD4count [448 (294.5-662) vs. 352 (176-514) cells/μl p<0.001]. There were no association between HLA-B5701 and survival for any given end-point. Higher mortality was associated to male gender, intravenous drug users, lower CD4 count at baseline and higher baseline viral load.<h4>Conclusions</h4>In our study, the presence of HLA-B*5701 allel was not associated with mortality rate of HIV infected patients, irrespective of being associated with both higher baseline CD4 + cell count and lower baseline HIV viral load.
format	article
author	Bogusz Jan Aksak-Wąs Miłosz Parczewski Anna Urbańska Małgorzata Hackiewicz Justyna D Kowalska
author_facet	Bogusz Jan Aksak-Wąs Miłosz Parczewski Anna Urbańska Małgorzata Hackiewicz Justyna D Kowalska
author_sort	Bogusz Jan Aksak-Wąs
title	Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV.
title_short	Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV.
title_full	Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV.
title_fullStr	Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV.
title_full_unstemmed	Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV.
title_sort	influence of hla-b*5701 on 20 year survival rate among patients living with hiv.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/2680cbe99157415383d749e64dff8905
work_keys_str_mv	AT boguszjanaksakwas influenceofhlab5701on20yearsurvivalrateamongpatientslivingwithhiv AT miłoszparczewski influenceofhlab5701on20yearsurvivalrateamongpatientslivingwithhiv AT annaurbanska influenceofhlab5701on20yearsurvivalrateamongpatientslivingwithhiv AT małgorzatahackiewicz influenceofhlab5701on20yearsurvivalrateamongpatientslivingwithhiv AT justynadkowalska influenceofhlab5701on20yearsurvivalrateamongpatientslivingwithhiv
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Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV.

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