Cell migration guided by long-lived spatial memory

Cells can modify their environment by depositing biochemical signals or mechanically remodelling the extracellular matrix; the impact of such self-induced environmental perturbations on cell trajectories at various scales remains unexplored. Here authors show that motile cells leave long-lived physi...

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Autores principales: Joseph d’Alessandro, Alex Barbier--Chebbah, Victor Cellerin, Olivier Benichou, René Marc Mège, Raphaël Voituriez, Benoît Ladoux
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/268158904f244d47990df743d63d0976
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Sumario:Cells can modify their environment by depositing biochemical signals or mechanically remodelling the extracellular matrix; the impact of such self-induced environmental perturbations on cell trajectories at various scales remains unexplored. Here authors show that motile cells leave long-lived physicochemical footprints along their way, which determine their future path.