Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis

Oligodendrocyte progenitor cells (OPCs) undergo asymmetric cell division, and disruption of such mechanism can generate oligodendroglioma precursors. Here, Daynac and colleagues show that Lgl1 regulates asymmetric division and differentiation of OPCs by interfering with the endocytosis pathway, and...

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Autores principales:	Mathieu Daynac, Malek Chouchane, Hannah Y. Collins, Nicole E. Murphy, Noemi Andor, Jianqin Niu, Stephen P. J. Fancy, William B. Stallcup, Claudia K. Petritsch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26828c1df785418aa023dd61fa643620
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spelling	oai:doaj.org-article:26828c1df785418aa023dd61fa6436202021-12-02T16:49:39ZLgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis10.1038/s41467-018-05099-32041-1723https://doaj.org/article/26828c1df785418aa023dd61fa6436202018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05099-3https://doaj.org/toc/2041-1723Oligodendrocyte progenitor cells (OPCs) undergo asymmetric cell division, and disruption of such mechanism can generate oligodendroglioma precursors. Here, Daynac and colleagues show that Lgl1 regulates asymmetric division and differentiation of OPCs by interfering with the endocytosis pathway, and that Lgl1 knockout can lead to gliomagenesis.Mathieu DaynacMalek ChouchaneHannah Y. CollinsNicole E. MurphyNoemi AndorJianqin NiuStephen P. J. FancyWilliam B. StallcupClaudia K. PetritschNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mathieu Daynac Malek Chouchane Hannah Y. Collins Nicole E. Murphy Noemi Andor Jianqin Niu Stephen P. J. Fancy William B. Stallcup Claudia K. Petritsch Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis
description	Oligodendrocyte progenitor cells (OPCs) undergo asymmetric cell division, and disruption of such mechanism can generate oligodendroglioma precursors. Here, Daynac and colleagues show that Lgl1 regulates asymmetric division and differentiation of OPCs by interfering with the endocytosis pathway, and that Lgl1 knockout can lead to gliomagenesis.
format	article
author	Mathieu Daynac Malek Chouchane Hannah Y. Collins Nicole E. Murphy Noemi Andor Jianqin Niu Stephen P. J. Fancy William B. Stallcup Claudia K. Petritsch
author_facet	Mathieu Daynac Malek Chouchane Hannah Y. Collins Nicole E. Murphy Noemi Andor Jianqin Niu Stephen P. J. Fancy William B. Stallcup Claudia K. Petritsch
author_sort	Mathieu Daynac
title	Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis
title_short	Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis
title_full	Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis
title_fullStr	Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis
title_full_unstemmed	Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis
title_sort	lgl1 controls ng2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/26828c1df785418aa023dd61fa643620
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Lgl1 controls NG2 endocytic pathway to regulate oligodendrocyte differentiation and asymmetric cell division and gliomagenesis

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