Genetics and evolution of the Salmonella galactose-initiated set of o antigens.

This paper covers eight Salmonella serogroups, that are defined by O antigens with related structures and gene clusters. They include the serovars that are now most frequently isolated. Serogroups A, B1, B2, C2-C3, D1, D2, D3 and E have O antigens that are distinguished by having galactose as first...

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Autores principales:	Peter R Reeves, Monica M Cunneen, Bin Liu, Lei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/268ee17872164370bc8b792d8580bd28
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spelling	oai:doaj.org-article:268ee17872164370bc8b792d8580bd282021-11-18T07:37:13ZGenetics and evolution of the Salmonella galactose-initiated set of o antigens.1932-620310.1371/journal.pone.0069306https://doaj.org/article/268ee17872164370bc8b792d8580bd282013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874940/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203This paper covers eight Salmonella serogroups, that are defined by O antigens with related structures and gene clusters. They include the serovars that are now most frequently isolated. Serogroups A, B1, B2, C2-C3, D1, D2, D3 and E have O antigens that are distinguished by having galactose as first sugar, and not N-acetyl glucosamine or N-acetyl galactosamine as in the other 38 serogroups, and indeed in most Enterobacteriaceae. The gene clusters for these galactose-initiated appear to have entered S. enterica since its divergence from E. coli, but sequence comparisons show that much of the diversification occurred long before this. We conclude that the gene clusters must have entered S. enterica in a series of parallel events. The individual gene clusters are discussed, followed by analysis of the divergence for those genes shared by two or more gene clusters, and a putative phylogenic tree for the gene clusters is presented. This set of O antigens provides a rare case where it is possible to examine in detail the relationships of a significant number of O antigens. In contrast the more common pattern of O-antigen diversity within a species is for there to be only a few cases of strains having related gene clusters, suggesting that diversity arose through gain of individual O-antigen gene clusters by lateral gene transfer, and under these circumstances the evolution of the diversity is not accessible. This paper on the galactose-initiated set of gene clusters gives new insights into the origins of O-antigen diversity generally.Peter R ReevesMonica M CunneenBin LiuLei WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e69306 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter R Reeves Monica M Cunneen Bin Liu Lei Wang Genetics and evolution of the Salmonella galactose-initiated set of o antigens.
description	This paper covers eight Salmonella serogroups, that are defined by O antigens with related structures and gene clusters. They include the serovars that are now most frequently isolated. Serogroups A, B1, B2, C2-C3, D1, D2, D3 and E have O antigens that are distinguished by having galactose as first sugar, and not N-acetyl glucosamine or N-acetyl galactosamine as in the other 38 serogroups, and indeed in most Enterobacteriaceae. The gene clusters for these galactose-initiated appear to have entered S. enterica since its divergence from E. coli, but sequence comparisons show that much of the diversification occurred long before this. We conclude that the gene clusters must have entered S. enterica in a series of parallel events. The individual gene clusters are discussed, followed by analysis of the divergence for those genes shared by two or more gene clusters, and a putative phylogenic tree for the gene clusters is presented. This set of O antigens provides a rare case where it is possible to examine in detail the relationships of a significant number of O antigens. In contrast the more common pattern of O-antigen diversity within a species is for there to be only a few cases of strains having related gene clusters, suggesting that diversity arose through gain of individual O-antigen gene clusters by lateral gene transfer, and under these circumstances the evolution of the diversity is not accessible. This paper on the galactose-initiated set of gene clusters gives new insights into the origins of O-antigen diversity generally.
format	article
author	Peter R Reeves Monica M Cunneen Bin Liu Lei Wang
author_facet	Peter R Reeves Monica M Cunneen Bin Liu Lei Wang
author_sort	Peter R Reeves
title	Genetics and evolution of the Salmonella galactose-initiated set of o antigens.
title_short	Genetics and evolution of the Salmonella galactose-initiated set of o antigens.
title_full	Genetics and evolution of the Salmonella galactose-initiated set of o antigens.
title_fullStr	Genetics and evolution of the Salmonella galactose-initiated set of o antigens.
title_full_unstemmed	Genetics and evolution of the Salmonella galactose-initiated set of o antigens.
title_sort	genetics and evolution of the salmonella galactose-initiated set of o antigens.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/268ee17872164370bc8b792d8580bd28
work_keys_str_mv	AT peterrreeves geneticsandevolutionofthesalmonellagalactoseinitiatedsetofoantigens AT monicamcunneen geneticsandevolutionofthesalmonellagalactoseinitiatedsetofoantigens AT binliu geneticsandevolutionofthesalmonellagalactoseinitiatedsetofoantigens AT leiwang geneticsandevolutionofthesalmonellagalactoseinitiatedsetofoantigens
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Genetics and evolution of the Salmonella galactose-initiated set of o antigens.

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