Dichotic listening performance and interhemispheric integration after administration of hydrocortisone

Abstract Chronic stress has been shown to have long-term effects on functional hemispheric asymmetries in both humans and non-human species. The short-term effects of acute stress exposure on functional hemispheric asymmetries are less well investigated. It has been suggested that acute stress can a...

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Autores principales:	Gesa Berretz, Julian Packheiser, Oliver Höffken, Oliver T. Wolf, Sebastian Ocklenburg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2693aef2e9eb48cb9d211b57a5fce1af
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spelling	oai:doaj.org-article:2693aef2e9eb48cb9d211b57a5fce1af2021-11-08T10:48:58ZDichotic listening performance and interhemispheric integration after administration of hydrocortisone10.1038/s41598-021-00896-12045-2322https://doaj.org/article/2693aef2e9eb48cb9d211b57a5fce1af2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00896-1https://doaj.org/toc/2045-2322Abstract Chronic stress has been shown to have long-term effects on functional hemispheric asymmetries in both humans and non-human species. The short-term effects of acute stress exposure on functional hemispheric asymmetries are less well investigated. It has been suggested that acute stress can affect functional hemispheric asymmetries by modulating inhibitory function of the corpus callosum, the white matter pathway that connects the two hemispheres. On the molecular level, this modulation may be caused by a stress-related increase in cortisol, a major stress hormone. Therefore, it was the aim of the present study to investigate the acute effects of cortisol on functional hemispheric asymmetries. Overall, 60 participants were tested after administration of 20 mg hydrocortisone or a placebo tablet in a cross-over design. Both times, a verbal and an emotional dichotic listening task to assess language and emotional lateralization, as well as a Banich–Belger task to assess interhemispheric integration were applied. Lateralization quotients were determined for both reaction times and correctly identified syllables in both dichotic listening tasks. In the Banich–Belger task, across-field advantages were determined to quantify interhemispheric integration. While we could replicate previously reported findings for these tasks in the placebo session, we could not detect any differences in asymmetry between hydrocortisone and placebo treatment. This partially corroborates the results of a previous study we performed using social stress to induce cortisol increases. This suggests that an increase in cortisol does not influence dichotic listening performance on a behavioral level. As other studies reported an effect of stress hormones on functional hemispheric asymmetries on a neuro-functional level, future research using neuronal imaging methods would be helpful in the characterization of the relation of hemispheric asymmetries and stress hormones.Gesa BerretzJulian PackheiserOliver HöffkenOliver T. WolfSebastian OcklenburgNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gesa Berretz Julian Packheiser Oliver Höffken Oliver T. Wolf Sebastian Ocklenburg Dichotic listening performance and interhemispheric integration after administration of hydrocortisone
description	Abstract Chronic stress has been shown to have long-term effects on functional hemispheric asymmetries in both humans and non-human species. The short-term effects of acute stress exposure on functional hemispheric asymmetries are less well investigated. It has been suggested that acute stress can affect functional hemispheric asymmetries by modulating inhibitory function of the corpus callosum, the white matter pathway that connects the two hemispheres. On the molecular level, this modulation may be caused by a stress-related increase in cortisol, a major stress hormone. Therefore, it was the aim of the present study to investigate the acute effects of cortisol on functional hemispheric asymmetries. Overall, 60 participants were tested after administration of 20 mg hydrocortisone or a placebo tablet in a cross-over design. Both times, a verbal and an emotional dichotic listening task to assess language and emotional lateralization, as well as a Banich–Belger task to assess interhemispheric integration were applied. Lateralization quotients were determined for both reaction times and correctly identified syllables in both dichotic listening tasks. In the Banich–Belger task, across-field advantages were determined to quantify interhemispheric integration. While we could replicate previously reported findings for these tasks in the placebo session, we could not detect any differences in asymmetry between hydrocortisone and placebo treatment. This partially corroborates the results of a previous study we performed using social stress to induce cortisol increases. This suggests that an increase in cortisol does not influence dichotic listening performance on a behavioral level. As other studies reported an effect of stress hormones on functional hemispheric asymmetries on a neuro-functional level, future research using neuronal imaging methods would be helpful in the characterization of the relation of hemispheric asymmetries and stress hormones.
format	article
author	Gesa Berretz Julian Packheiser Oliver Höffken Oliver T. Wolf Sebastian Ocklenburg
author_facet	Gesa Berretz Julian Packheiser Oliver Höffken Oliver T. Wolf Sebastian Ocklenburg
author_sort	Gesa Berretz
title	Dichotic listening performance and interhemispheric integration after administration of hydrocortisone
title_short	Dichotic listening performance and interhemispheric integration after administration of hydrocortisone
title_full	Dichotic listening performance and interhemispheric integration after administration of hydrocortisone
title_fullStr	Dichotic listening performance and interhemispheric integration after administration of hydrocortisone
title_full_unstemmed	Dichotic listening performance and interhemispheric integration after administration of hydrocortisone
title_sort	dichotic listening performance and interhemispheric integration after administration of hydrocortisone
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2693aef2e9eb48cb9d211b57a5fce1af
work_keys_str_mv	AT gesaberretz dichoticlisteningperformanceandinterhemisphericintegrationafteradministrationofhydrocortisone AT julianpackheiser dichoticlisteningperformanceandinterhemisphericintegrationafteradministrationofhydrocortisone AT oliverhoffken dichoticlisteningperformanceandinterhemisphericintegrationafteradministrationofhydrocortisone AT olivertwolf dichoticlisteningperformanceandinterhemisphericintegrationafteradministrationofhydrocortisone AT sebastianocklenburg dichoticlisteningperformanceandinterhemisphericintegrationafteradministrationofhydrocortisone
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Dichotic listening performance and interhemispheric integration after administration of hydrocortisone

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