Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims

A Sanchez-Bahillo1, V Bautista-Hernandez1, Carlos Barcia Gonzalez1, R Ba&ntilde;on2, A Luna2, EC Hirsch3, Maria-Trinidad Herrero11Clinical and Experimental Neuroscience, Centro de Investigaci&oacute;n Biom&eacute;dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED); 2...

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Autores principales:	A Sanchez-Bahillo, V Bautista-Hernandez, Carlos Barcia Gonzalez, R Ba&ntilde;on, A Luna, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2693eaf190eb438b98097e25cf2869ce
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spelling	oai:doaj.org-article:2693eaf190eb438b98097e25cf2869ce2021-12-02T00:25:45ZIncreased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims1176-63281178-2021https://doaj.org/article/2693eaf190eb438b98097e25cf2869ce2008-04-01T00:00:00Zhttp://www.dovepress.com/increased-mrna-expression-of-cytochrome-oxidase-in-dorsal-raphe-nucleu-a1028https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021A Sanchez-Bahillo1, V Bautista-Hernandez1, Carlos Barcia Gonzalez1, R Ba&ntilde;on2, A Luna2, EC Hirsch3, Maria-Trinidad Herrero11Clinical and Experimental Neuroscience, Centro de Investigaci&oacute;n Biom&eacute;dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED); 2Department of Legal Medicine, Department of Human Anatomy, School of Medicine, University of Murcia, Campus de Espinardo, Murcia 30100, Spain; 3INSERM U679 H&ocirc;pital de la Salp&ecirc;tri&egrave;re, Boulevard de l&rsquo;H&ocirc;pital, Paris, FranceAbstract: Suicidal behavior is a problem with important social repercussions. Some groups of the population show a higher risk of suicide; for example, depression, alcoholism, psychosis or drug abuse frequently precedes suicidal behavior. However, the relationship between metabolic alterations in the brain and premorbid clinical symptoms of suicide remains uncertain. The serotonergic and noradrenergic systems have frequently been, implicated in suicidal behavior and the amount of serotonin in the brain and CSF of suicide victims has been found to be low compared with normal subjects. However, there are contradictory results regarding the role of noradrenergic neurons in the mediation of suicide attempts, possibly reflecting the heterogeneity of conditions that lead to a common outcome. In the present work we focus on the subgroup of suicide victims that share a common diagnosis of major depression. Based on post-mortem studies analyzing mRNA expression by in situ hybridization, serotonergic neurons from the dorsal raphe nucleus (DRN) from depressive suicide victims are seen to over-express cytochrome oxidase mRNA. However, no corresponding changes were found in the expression of tyrosine hydroxylase (TH) mRNA in the noradrenergic neurons of the Locus Coeruleus (LC). These results suggest that, despite of the low levels of serotonin described in suicide victims, the activity of DRN neurons could increase in the suicidally depressed, probably due to the over activation of serotonin re-uptake. No alteration was found in noradrenergic neurons, suggesting that they play no crucial role in the suicidal behavior of depressive patients.Keywords: depression, suicidal behavior, dorsal raphe nucleus, noradrenergic neurons A Sanchez-BahilloV Bautista-HernandezCarlos Barcia GonzalezR Ba&ntilde;onA Lunaet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 2, Pp 413-416 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 A Sanchez-Bahillo V Bautista-Hernandez Carlos Barcia Gonzalez R Ba&ntilde;on A Luna et al Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims
description	A Sanchez-Bahillo1, V Bautista-Hernandez1, Carlos Barcia Gonzalez1, R Ba&ntilde;on2, A Luna2, EC Hirsch3, Maria-Trinidad Herrero11Clinical and Experimental Neuroscience, Centro de Investigaci&oacute;n Biom&eacute;dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED); 2Department of Legal Medicine, Department of Human Anatomy, School of Medicine, University of Murcia, Campus de Espinardo, Murcia 30100, Spain; 3INSERM U679 H&ocirc;pital de la Salp&ecirc;tri&egrave;re, Boulevard de l&rsquo;H&ocirc;pital, Paris, FranceAbstract: Suicidal behavior is a problem with important social repercussions. Some groups of the population show a higher risk of suicide; for example, depression, alcoholism, psychosis or drug abuse frequently precedes suicidal behavior. However, the relationship between metabolic alterations in the brain and premorbid clinical symptoms of suicide remains uncertain. The serotonergic and noradrenergic systems have frequently been, implicated in suicidal behavior and the amount of serotonin in the brain and CSF of suicide victims has been found to be low compared with normal subjects. However, there are contradictory results regarding the role of noradrenergic neurons in the mediation of suicide attempts, possibly reflecting the heterogeneity of conditions that lead to a common outcome. In the present work we focus on the subgroup of suicide victims that share a common diagnosis of major depression. Based on post-mortem studies analyzing mRNA expression by in situ hybridization, serotonergic neurons from the dorsal raphe nucleus (DRN) from depressive suicide victims are seen to over-express cytochrome oxidase mRNA. However, no corresponding changes were found in the expression of tyrosine hydroxylase (TH) mRNA in the noradrenergic neurons of the Locus Coeruleus (LC). These results suggest that, despite of the low levels of serotonin described in suicide victims, the activity of DRN neurons could increase in the suicidally depressed, probably due to the over activation of serotonin re-uptake. No alteration was found in noradrenergic neurons, suggesting that they play no crucial role in the suicidal behavior of depressive patients.Keywords: depression, suicidal behavior, dorsal raphe nucleus, noradrenergic neurons
format	article
author	A Sanchez-Bahillo V Bautista-Hernandez Carlos Barcia Gonzalez R Ba&ntilde;on A Luna et al
author_facet	A Sanchez-Bahillo V Bautista-Hernandez Carlos Barcia Gonzalez R Ba&ntilde;on A Luna et al
author_sort	A Sanchez-Bahillo
title	Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims
title_short	Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims
title_full	Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims
title_fullStr	Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims
title_full_unstemmed	Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims
title_sort	increased mrna expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/2693eaf190eb438b98097e25cf2869ce
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_version_	1718403729253728256

Increased mRNA expression of cytochrome oxidase in dorsal raphe nucleus of depressive suicide victims

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