Research Progress of circRNAs in Glioblastoma

Circular RNAs (circRNAs) are a class of single-stranded covalently closed non-coding RNAs without a 5′ cap structure or 3′ terminal poly (A) tail, which are expressed in a variety of tissues and cells with conserved, stable and specific characteristics. Glioblastoma (GBM) is the most aggressive and...

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Autores principales:	Xu Guo, Haozhe Piao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	circRNAs non-coding RNAs biomarker glioblastoma miRNAs sponge Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/269796e45abf48108fe1c5513ecee936
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spelling	oai:doaj.org-article:269796e45abf48108fe1c5513ecee9362021-11-22T06:54:35ZResearch Progress of circRNAs in Glioblastoma2296-634X10.3389/fcell.2021.791892https://doaj.org/article/269796e45abf48108fe1c5513ecee9362021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.791892/fullhttps://doaj.org/toc/2296-634XCircular RNAs (circRNAs) are a class of single-stranded covalently closed non-coding RNAs without a 5′ cap structure or 3′ terminal poly (A) tail, which are expressed in a variety of tissues and cells with conserved, stable and specific characteristics. Glioblastoma (GBM) is the most aggressive and lethal tumor in the central nervous system, characterized by high recurrence and mortality rates. The specific expression of circRNAs in GBM has demonstrated their potential to become new biomarkers for the development of GBM. The specific expression of circRNAs in GBM has shown their potential as new biomarkers for GBM cell proliferation, apoptosis, migration and invasion, which provides new ideas for GBM treatment. In this paper, we will review the biological properties and functions of circRNAs and their biological roles and clinical applications in GBM.Xu GuoHaozhe PiaoFrontiers Media S.A.articlecircRNAsnon-coding RNAsbiomarkerglioblastomamiRNAs spongeBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circRNAs non-coding RNAs biomarker glioblastoma miRNAs sponge Biology (General) QH301-705.5
spellingShingle	circRNAs non-coding RNAs biomarker glioblastoma miRNAs sponge Biology (General) QH301-705.5 Xu Guo Haozhe Piao Research Progress of circRNAs in Glioblastoma
description	Circular RNAs (circRNAs) are a class of single-stranded covalently closed non-coding RNAs without a 5′ cap structure or 3′ terminal poly (A) tail, which are expressed in a variety of tissues and cells with conserved, stable and specific characteristics. Glioblastoma (GBM) is the most aggressive and lethal tumor in the central nervous system, characterized by high recurrence and mortality rates. The specific expression of circRNAs in GBM has demonstrated their potential to become new biomarkers for the development of GBM. The specific expression of circRNAs in GBM has shown their potential as new biomarkers for GBM cell proliferation, apoptosis, migration and invasion, which provides new ideas for GBM treatment. In this paper, we will review the biological properties and functions of circRNAs and their biological roles and clinical applications in GBM.
format	article
author	Xu Guo Haozhe Piao
author_facet	Xu Guo Haozhe Piao
author_sort	Xu Guo
title	Research Progress of circRNAs in Glioblastoma
title_short	Research Progress of circRNAs in Glioblastoma
title_full	Research Progress of circRNAs in Glioblastoma
title_fullStr	Research Progress of circRNAs in Glioblastoma
title_full_unstemmed	Research Progress of circRNAs in Glioblastoma
title_sort	research progress of circrnas in glioblastoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/269796e45abf48108fe1c5513ecee936
work_keys_str_mv	AT xuguo researchprogressofcircrnasinglioblastoma AT haozhepiao researchprogressofcircrnasinglioblastoma
_version_	1718418091266801664

Research Progress of circRNAs in Glioblastoma

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