Hantavirus infection with pulmonary symptoms in north central part of Sri Lanka

Background: Classical hantavirus infections present as haemorrhagic fever with renal syndrome (HFRS) in Euro-Asia and as hantavirus pulmonary syndrome (HPS) in America. Mixed clinical features have been reported from certain novel hantavirus infections. In the north-central part of Sri Lanka, clust...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rohitha Muthugala, Kalpa Dheerasekara, Nandika Harischandra, Darshana Wickramasinghe, Mudhitha Abeykoon, Dhanushka Dasanayake, Aresha Manamperi, Sunethra Gunasena, Geethani Galagoda
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Sri Lanka hantavirus pulmonary symptoms Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/26989c3f992b45d5b9bcfcf08526644b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:26989c3f992b45d5b9bcfcf08526644b
record_format	dspace
spelling	oai:doaj.org-article:26989c3f992b45d5b9bcfcf08526644b2021-11-14T04:36:12ZHantavirus infection with pulmonary symptoms in north central part of Sri Lanka2667-038010.1016/j.jcvp.2021.100052https://doaj.org/article/26989c3f992b45d5b9bcfcf08526644b2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667038021000442https://doaj.org/toc/2667-0380Background: Classical hantavirus infections present as haemorrhagic fever with renal syndrome (HFRS) in Euro-Asia and as hantavirus pulmonary syndrome (HPS) in America. Mixed clinical features have been reported from certain novel hantavirus infections. In the north-central part of Sri Lanka, clusters of patients with fever and non-cardiogenic pulmonary edema have been reported in recent years. Objectives: To detect hantavirus infection among clinically suspected patients and to describe clinical and demographic features of hantavirus infection in north-central Sri Lanka. Study design: Clinically suspected patients with HFRS and HPS like illness admitted to two leading hospitals in the north-central part of the country from December 2013 to November 2015 and from March 2016 to February 2018 were included in the study. Acute phase blood samples were tested for the presence of anti-hantavirus IgM. Convalescent blood samples were taken from available cases and both acute and convalescent sera were subjected to IgG titre detection. Results: Seventy-two patients were included in the study. Twenty-nine (40.28%) were positive for hantavirus IgM. Of them, 20 (68.97%) presented with pulmonary symptoms with no or mild nephritis. Five (17.24%) had pulmonary symptoms with prominent nephritis and 04 (13.79%) had classic features of HFRS. Conclusion: In the north-central part of Sri Lanka, most hantavirus infection was associated with pulmonary symptoms complicated with non-cardiogenic pulmonary edema, which was different from clinical presentation reported previously from other parts of the country. HPS like hantavirus infection in the study area could be due to a Puumala-like virus or a novel virus.Rohitha MuthugalaKalpa DheerasekaraNandika HarischandraDarshana WickramasingheMudhitha AbeykoonDhanushka DasanayakeAresha ManamperiSunethra GunasenaGeethani GalagodaElsevierarticleSri Lankahantaviruspulmonary symptomsInfectious and parasitic diseasesRC109-216ENJournal of Clinical Virology Plus, Vol 1, Iss 4, Pp 100052- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sri Lanka hantavirus pulmonary symptoms Infectious and parasitic diseases RC109-216
spellingShingle	Sri Lanka hantavirus pulmonary symptoms Infectious and parasitic diseases RC109-216 Rohitha Muthugala Kalpa Dheerasekara Nandika Harischandra Darshana Wickramasinghe Mudhitha Abeykoon Dhanushka Dasanayake Aresha Manamperi Sunethra Gunasena Geethani Galagoda Hantavirus infection with pulmonary symptoms in north central part of Sri Lanka
description	Background: Classical hantavirus infections present as haemorrhagic fever with renal syndrome (HFRS) in Euro-Asia and as hantavirus pulmonary syndrome (HPS) in America. Mixed clinical features have been reported from certain novel hantavirus infections. In the north-central part of Sri Lanka, clusters of patients with fever and non-cardiogenic pulmonary edema have been reported in recent years. Objectives: To detect hantavirus infection among clinically suspected patients and to describe clinical and demographic features of hantavirus infection in north-central Sri Lanka. Study design: Clinically suspected patients with HFRS and HPS like illness admitted to two leading hospitals in the north-central part of the country from December 2013 to November 2015 and from March 2016 to February 2018 were included in the study. Acute phase blood samples were tested for the presence of anti-hantavirus IgM. Convalescent blood samples were taken from available cases and both acute and convalescent sera were subjected to IgG titre detection. Results: Seventy-two patients were included in the study. Twenty-nine (40.28%) were positive for hantavirus IgM. Of them, 20 (68.97%) presented with pulmonary symptoms with no or mild nephritis. Five (17.24%) had pulmonary symptoms with prominent nephritis and 04 (13.79%) had classic features of HFRS. Conclusion: In the north-central part of Sri Lanka, most hantavirus infection was associated with pulmonary symptoms complicated with non-cardiogenic pulmonary edema, which was different from clinical presentation reported previously from other parts of the country. HPS like hantavirus infection in the study area could be due to a Puumala-like virus or a novel virus.
format	article
author	Rohitha Muthugala Kalpa Dheerasekara Nandika Harischandra Darshana Wickramasinghe Mudhitha Abeykoon Dhanushka Dasanayake Aresha Manamperi Sunethra Gunasena Geethani Galagoda
author_facet	Rohitha Muthugala Kalpa Dheerasekara Nandika Harischandra Darshana Wickramasinghe Mudhitha Abeykoon Dhanushka Dasanayake Aresha Manamperi Sunethra Gunasena Geethani Galagoda
author_sort	Rohitha Muthugala
title	Hantavirus infection with pulmonary symptoms in north central part of Sri Lanka
title_short	Hantavirus infection with pulmonary symptoms in north central part of Sri Lanka
title_full	Hantavirus infection with pulmonary symptoms in north central part of Sri Lanka
title_fullStr	Hantavirus infection with pulmonary symptoms in north central part of Sri Lanka
title_full_unstemmed	Hantavirus infection with pulmonary symptoms in north central part of Sri Lanka
title_sort	hantavirus infection with pulmonary symptoms in north central part of sri lanka
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/26989c3f992b45d5b9bcfcf08526644b
work_keys_str_mv	AT rohithamuthugala hantavirusinfectionwithpulmonarysymptomsinnorthcentralpartofsrilanka AT kalpadheerasekara hantavirusinfectionwithpulmonarysymptomsinnorthcentralpartofsrilanka AT nandikaharischandra hantavirusinfectionwithpulmonarysymptomsinnorthcentralpartofsrilanka AT darshanawickramasinghe hantavirusinfectionwithpulmonarysymptomsinnorthcentralpartofsrilanka AT mudhithaabeykoon hantavirusinfectionwithpulmonarysymptomsinnorthcentralpartofsrilanka AT dhanushkadasanayake hantavirusinfectionwithpulmonarysymptomsinnorthcentralpartofsrilanka AT areshamanamperi hantavirusinfectionwithpulmonarysymptomsinnorthcentralpartofsrilanka AT sunethragunasena hantavirusinfectionwithpulmonarysymptomsinnorthcentralpartofsrilanka AT geethanigalagoda hantavirusinfectionwithpulmonarysymptomsinnorthcentralpartofsrilanka
_version_	1718429885694738432

Hantavirus infection with pulmonary symptoms in north central part of Sri Lanka

Ejemplares similares