Urine Uric Acid Excretion Levels are Positively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Patients without Chronic Kidney Disease

Fengjing Liu, Si Chen, Weijing Zhao, Mingyun Chen, Jiangfeng Ke, Zhihui Zhang, Junxi Lu, Lianxi Li Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory...

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Autores principales:	Liu F, Chen S, Zhao W, Chen M, Ke J, Zhang Z, Lu J, Li L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	urine uric acid excretion type 2 diabetes obesity abdominal obesity chronic kidney disease Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/269ca94ae9824af1a89740f315b8a0da
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spelling	oai:doaj.org-article:269ca94ae9824af1a89740f315b8a0da2021-11-30T18:50:36ZUrine Uric Acid Excretion Levels are Positively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Patients without Chronic Kidney Disease1178-7007https://doaj.org/article/269ca94ae9824af1a89740f315b8a0da2021-12-01T00:00:00Zhttps://www.dovepress.com/urine-uric-acid-excretion-levels-are-positively-associated-with-obesit-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Fengjing Liu, Si Chen, Weijing Zhao, Mingyun Chen, Jiangfeng Ke, Zhihui Zhang, Junxi Lu, Lianxi Li Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, People’s Republic of ChinaCorrespondence: Lianxi LiDepartment of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai, 200233, People’s Republic of ChinaTel +86 21 64369181x58337Email lilx@sjtu.edu.cnPurpose: We aimed to investigate whether urine uric acid excretion (UUAE) levels are associated with obesity and abdominal obesity in patients with type 2 diabetes (T2D).Methods: There were 2785 type 2 diabetic patients in this cross-sectional study. Obesity was defined as BMI ≥ 25 kg/m2, and abdominal obesity was defined as waist circumference (WC) ≥ 90 cm for men and WC ≥ 80 cm for women based on World Health Organization (WHO) recommendations for Asians. Chronic kidney disease (CKD) was defined as the estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2 and/or urinary albumin excretion (UAE) ≥ 300 mg/24h. 24-h UUAE was determined enzymatically using a single 24-hour urine collection. All the subjects were stratified into quartiles based on UUAE levels. Both obesity and abdominal obesity were compared among the UUAE quartile groups, respectively. Furthermore, the associations of UUAE with obesity and abdominal obesity were analyzed in both CKD and non-CKD patients, respectively.Results: There was an obvious increased trend in both obesity prevalence (36.2%, 41.5%, 46.3%, and 63.4%, respectively, p < 0.001 for trend) and abdominal obesity prevalence (58.1%, 61.2%, 64.7%, and 75.8%, respectively, p < 0.001 for trend) in patients with T2D across the UUAE quartiles after controlling for age, sex and diabetes duration. Multiple logistic regression analyses revealed independent associations between UUAE quartiles and obesity (p < 0.001) and abdominal obesity (p < 0.001) in all patients. However, UUAE was significantly associated with obesity and abdominal obesity only in the T2D patients without CKD (p < 0.001 in model 1, model 2, model 3 and model 4, respectively).Conclusion: Increased UUAE levels were significantly associated with the presence of obesity, especially abdominal obesity in T2D patients without CKD.Keywords: urine uric acid excretion, type 2 diabetes, obesity, abdominal obesity, chronic kidney diseaseLiu FChen SZhao WChen MKe JZhang ZLu JLi LDove Medical Pressarticleurine uric acid excretiontype 2 diabetesobesityabdominal obesitychronic kidney diseaseSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4691-4703 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	urine uric acid excretion type 2 diabetes obesity abdominal obesity chronic kidney disease Specialties of internal medicine RC581-951
spellingShingle	urine uric acid excretion type 2 diabetes obesity abdominal obesity chronic kidney disease Specialties of internal medicine RC581-951 Liu F Chen S Zhao W Chen M Ke J Zhang Z Lu J Li L Urine Uric Acid Excretion Levels are Positively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Patients without Chronic Kidney Disease
description	Fengjing Liu, Si Chen, Weijing Zhao, Mingyun Chen, Jiangfeng Ke, Zhihui Zhang, Junxi Lu, Lianxi Li Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, People’s Republic of ChinaCorrespondence: Lianxi LiDepartment of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai, 200233, People’s Republic of ChinaTel +86 21 64369181x58337Email lilx@sjtu.edu.cnPurpose: We aimed to investigate whether urine uric acid excretion (UUAE) levels are associated with obesity and abdominal obesity in patients with type 2 diabetes (T2D).Methods: There were 2785 type 2 diabetic patients in this cross-sectional study. Obesity was defined as BMI ≥ 25 kg/m2, and abdominal obesity was defined as waist circumference (WC) ≥ 90 cm for men and WC ≥ 80 cm for women based on World Health Organization (WHO) recommendations for Asians. Chronic kidney disease (CKD) was defined as the estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2 and/or urinary albumin excretion (UAE) ≥ 300 mg/24h. 24-h UUAE was determined enzymatically using a single 24-hour urine collection. All the subjects were stratified into quartiles based on UUAE levels. Both obesity and abdominal obesity were compared among the UUAE quartile groups, respectively. Furthermore, the associations of UUAE with obesity and abdominal obesity were analyzed in both CKD and non-CKD patients, respectively.Results: There was an obvious increased trend in both obesity prevalence (36.2%, 41.5%, 46.3%, and 63.4%, respectively, p < 0.001 for trend) and abdominal obesity prevalence (58.1%, 61.2%, 64.7%, and 75.8%, respectively, p < 0.001 for trend) in patients with T2D across the UUAE quartiles after controlling for age, sex and diabetes duration. Multiple logistic regression analyses revealed independent associations between UUAE quartiles and obesity (p < 0.001) and abdominal obesity (p < 0.001) in all patients. However, UUAE was significantly associated with obesity and abdominal obesity only in the T2D patients without CKD (p < 0.001 in model 1, model 2, model 3 and model 4, respectively).Conclusion: Increased UUAE levels were significantly associated with the presence of obesity, especially abdominal obesity in T2D patients without CKD.Keywords: urine uric acid excretion, type 2 diabetes, obesity, abdominal obesity, chronic kidney disease
format	article
author	Liu F Chen S Zhao W Chen M Ke J Zhang Z Lu J Li L
author_facet	Liu F Chen S Zhao W Chen M Ke J Zhang Z Lu J Li L
author_sort	Liu F
title	Urine Uric Acid Excretion Levels are Positively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Patients without Chronic Kidney Disease
title_short	Urine Uric Acid Excretion Levels are Positively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Patients without Chronic Kidney Disease
title_full	Urine Uric Acid Excretion Levels are Positively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Patients without Chronic Kidney Disease
title_fullStr	Urine Uric Acid Excretion Levels are Positively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Patients without Chronic Kidney Disease
title_full_unstemmed	Urine Uric Acid Excretion Levels are Positively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Patients without Chronic Kidney Disease
title_sort	urine uric acid excretion levels are positively associated with obesity and abdominal obesity in type 2 diabetes patients without chronic kidney disease
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/269ca94ae9824af1a89740f315b8a0da
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Urine Uric Acid Excretion Levels are Positively Associated with Obesity and Abdominal Obesity in Type 2 Diabetes Patients without Chronic Kidney Disease

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