The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. Metabolic reprogramming represents an important cancer hallmark in CRC. Reprogramming core metabolic pathways in cancer cells, such as glycolysis, glutaminolysis, oxidative phosphorylation, and lipid metabolism, is es...

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Autores principales:	Kha Wai Hon, Syafiq Asnawi Zainal Abidin, Iekhsan Othman, Rakesh Naidu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	colorectal cancer metabolism metabolic reprogramming protein kinase signaling pathways Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/269eaffe7ff24552be70c3e8fa8e28dc
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id	oai:doaj.org-article:269eaffe7ff24552be70c3e8fa8e28dc
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spelling	oai:doaj.org-article:269eaffe7ff24552be70c3e8fa8e28dc2021-11-30T13:47:33ZThe Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer1663-981210.3389/fphar.2021.768861https://doaj.org/article/269eaffe7ff24552be70c3e8fa8e28dc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.768861/fullhttps://doaj.org/toc/1663-9812Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. Metabolic reprogramming represents an important cancer hallmark in CRC. Reprogramming core metabolic pathways in cancer cells, such as glycolysis, glutaminolysis, oxidative phosphorylation, and lipid metabolism, is essential to increase energy production and biosynthesis of precursors required to support tumor initiation and progression. Accumulating evidence demonstrates that activation of oncogenes and loss of tumor suppressor genes regulate metabolic reprogramming through the downstream signaling pathways. Protein kinases, such as AKT and c-MYC, are the integral components that facilitate the crosstalk between signaling pathways and metabolic pathways in CRC. This review provides an insight into the crosstalk between signaling pathways and metabolic reprogramming in CRC. Targeting CRC metabolism could open a new avenue for developing CRC therapy by discovering metabolic inhibitors and repurposing protein kinase inhibitors/monoclonal antibodies.Kha Wai HonSyafiq Asnawi Zainal AbidinIekhsan OthmanRakesh NaiduFrontiers Media S.A.articlecolorectal cancermetabolismmetabolic reprogrammingprotein kinasesignaling pathwaysTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal cancer metabolism metabolic reprogramming protein kinase signaling pathways Therapeutics. Pharmacology RM1-950
spellingShingle	colorectal cancer metabolism metabolic reprogramming protein kinase signaling pathways Therapeutics. Pharmacology RM1-950 Kha Wai Hon Syafiq Asnawi Zainal Abidin Iekhsan Othman Rakesh Naidu The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer
description	Colorectal cancer (CRC) is one of the most frequently diagnosed cancers worldwide. Metabolic reprogramming represents an important cancer hallmark in CRC. Reprogramming core metabolic pathways in cancer cells, such as glycolysis, glutaminolysis, oxidative phosphorylation, and lipid metabolism, is essential to increase energy production and biosynthesis of precursors required to support tumor initiation and progression. Accumulating evidence demonstrates that activation of oncogenes and loss of tumor suppressor genes regulate metabolic reprogramming through the downstream signaling pathways. Protein kinases, such as AKT and c-MYC, are the integral components that facilitate the crosstalk between signaling pathways and metabolic pathways in CRC. This review provides an insight into the crosstalk between signaling pathways and metabolic reprogramming in CRC. Targeting CRC metabolism could open a new avenue for developing CRC therapy by discovering metabolic inhibitors and repurposing protein kinase inhibitors/monoclonal antibodies.
format	article
author	Kha Wai Hon Syafiq Asnawi Zainal Abidin Iekhsan Othman Rakesh Naidu
author_facet	Kha Wai Hon Syafiq Asnawi Zainal Abidin Iekhsan Othman Rakesh Naidu
author_sort	Kha Wai Hon
title	The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer
title_short	The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer
title_full	The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer
title_fullStr	The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer
title_full_unstemmed	The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer
title_sort	crosstalk between signaling pathways and cancer metabolism in colorectal cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/269eaffe7ff24552be70c3e8fa8e28dc
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The Crosstalk Between Signaling Pathways and Cancer Metabolism in Colorectal Cancer

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