Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis.

<h4>Objective</h4>The purpose of this study was to evaluate the diagnostic efficacy of Xpert MTB/RIF for tuberculous pericarditis (TBP).<h4>Methods</h4>We searched relevant databases for Xpert MTB/RIF for TBP diagnosis until April 2021 and screened eligible studies for study...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Guocan Yu, Fangming Zhong, Yanqin Shen, Hong Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/26a03a73e5d548a6a64f9749b9875a5e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:26a03a73e5d548a6a64f9749b9875a5e
record_format	dspace
spelling	oai:doaj.org-article:26a03a73e5d548a6a64f9749b9875a5e2021-12-02T20:14:41ZDiagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis.1932-620310.1371/journal.pone.0257220https://doaj.org/article/26a03a73e5d548a6a64f9749b9875a5e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257220https://doaj.org/toc/1932-6203<h4>Objective</h4>The purpose of this study was to evaluate the diagnostic efficacy of Xpert MTB/RIF for tuberculous pericarditis (TBP).<h4>Methods</h4>We searched relevant databases for Xpert MTB/RIF for TBP diagnosis until April 2021 and screened eligible studies for study inclusion. We evaluated the effectiveness of Xpert MTB/RIF when the composite reference standard (CRS) and mycobacterial culture were the gold standards, respectively. We performed meta-analyses using a bivariate random-effects model, and when the heterogeneity was obvious, the source of heterogeneity was further discussed.<h4>Results</h4>We included seven independent studies comparing Xpert MTB/RIF with the CRS and six studies comparing it with culture. The pooled sensitivity, specificity, and area under the curve of Xpert MTB/RIF were 65% (95% confidence interval, 59-72%), 99% (97-100%), and 0.99 (0.97-0.99) as compared with the CRS, respectively, and 75% (53-88%), 99% (90-100%), and 0.94 (0.92-0.96) as compared with culture, respectively. There was no significant heterogeneity between studies when CRS was the gold standard, whereas heterogeneity was evident when culture was the gold standard.<h4>Conclusions</h4>The sensitivity of Xpert MTB/RIF for diagnosing TBP was moderate and the specificity was good; thus, Xpert MTB/RIF can be used in the initial diagnosis of TBP.Guocan YuFangming ZhongYanqin ShenHong ZhengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257220 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guocan Yu Fangming Zhong Yanqin Shen Hong Zheng Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis.
description	<h4>Objective</h4>The purpose of this study was to evaluate the diagnostic efficacy of Xpert MTB/RIF for tuberculous pericarditis (TBP).<h4>Methods</h4>We searched relevant databases for Xpert MTB/RIF for TBP diagnosis until April 2021 and screened eligible studies for study inclusion. We evaluated the effectiveness of Xpert MTB/RIF when the composite reference standard (CRS) and mycobacterial culture were the gold standards, respectively. We performed meta-analyses using a bivariate random-effects model, and when the heterogeneity was obvious, the source of heterogeneity was further discussed.<h4>Results</h4>We included seven independent studies comparing Xpert MTB/RIF with the CRS and six studies comparing it with culture. The pooled sensitivity, specificity, and area under the curve of Xpert MTB/RIF were 65% (95% confidence interval, 59-72%), 99% (97-100%), and 0.99 (0.97-0.99) as compared with the CRS, respectively, and 75% (53-88%), 99% (90-100%), and 0.94 (0.92-0.96) as compared with culture, respectively. There was no significant heterogeneity between studies when CRS was the gold standard, whereas heterogeneity was evident when culture was the gold standard.<h4>Conclusions</h4>The sensitivity of Xpert MTB/RIF for diagnosing TBP was moderate and the specificity was good; thus, Xpert MTB/RIF can be used in the initial diagnosis of TBP.
format	article
author	Guocan Yu Fangming Zhong Yanqin Shen Hong Zheng
author_facet	Guocan Yu Fangming Zhong Yanqin Shen Hong Zheng
author_sort	Guocan Yu
title	Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis.
title_short	Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis.
title_full	Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis.
title_fullStr	Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis.
title_full_unstemmed	Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis.
title_sort	diagnostic accuracy of the xpert mtb/rif assay for tuberculous pericarditis: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/26a03a73e5d548a6a64f9749b9875a5e
work_keys_str_mv	AT guocanyu diagnosticaccuracyofthexpertmtbrifassayfortuberculouspericarditisasystematicreviewandmetaanalysis AT fangmingzhong diagnosticaccuracyofthexpertmtbrifassayfortuberculouspericarditisasystematicreviewandmetaanalysis AT yanqinshen diagnosticaccuracyofthexpertmtbrifassayfortuberculouspericarditisasystematicreviewandmetaanalysis AT hongzheng diagnosticaccuracyofthexpertmtbrifassayfortuberculouspericarditisasystematicreviewandmetaanalysis
_version_	1718374633399386112

Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis.

Ejemplares similares