Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant
Multiple myeloma (MM) is treated with induction chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. Here, the authors show that the presence of clonal haematopoiesis of indeterminate potential (CHIP) at time of ASCT is associated with adverse...
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Nature Portfolio
2020
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oai:doaj.org-article:26a4f18ed00849e6bce820eacad6b32d2021-12-02T14:58:23ZClonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant10.1038/s41467-020-16805-52041-1723https://doaj.org/article/26a4f18ed00849e6bce820eacad6b32d2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16805-5https://doaj.org/toc/2041-1723Multiple myeloma (MM) is treated with induction chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. Here, the authors show that the presence of clonal haematopoiesis of indeterminate potential (CHIP) at time of ASCT is associated with adverse outcomes in MM patients.Tarek H. MouhieddineAdam S. SperlingRobert ReddJihye ParkMatthew LeventhalChristopher J. GibsonSalomon ManierAmin H. NassarMarzia CapellettiDaisy HuynhMark BustorosRomanos Sklavenitis-PistofidisSabrin TahriKalvis HornburgHenry DumkeMuhieddine M. ItaniCody J. BoehnerChia-Jen LiuSaud H. AlDubayanBrendan ReardonEliezer M. Van AllenJonathan J. KeatsChip StewartShaadi MehrDaniel AuclairRobert L. SchlossmanNikhil C. MunshiKenneth C. AndersonDavid P. SteensmaJacob P. LaubachPaul G. RichardsonJerome RitzBenjamin L. EbertRobert J. SoifferLorenzo TrippaGad GetzDonna S. NeubergIrene M. GhobrialNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020) |
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DOAJ |
| collection |
DOAJ |
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EN |
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Science Q |
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Science Q Tarek H. Mouhieddine Adam S. Sperling Robert Redd Jihye Park Matthew Leventhal Christopher J. Gibson Salomon Manier Amin H. Nassar Marzia Capelletti Daisy Huynh Mark Bustoros Romanos Sklavenitis-Pistofidis Sabrin Tahri Kalvis Hornburg Henry Dumke Muhieddine M. Itani Cody J. Boehner Chia-Jen Liu Saud H. AlDubayan Brendan Reardon Eliezer M. Van Allen Jonathan J. Keats Chip Stewart Shaadi Mehr Daniel Auclair Robert L. Schlossman Nikhil C. Munshi Kenneth C. Anderson David P. Steensma Jacob P. Laubach Paul G. Richardson Jerome Ritz Benjamin L. Ebert Robert J. Soiffer Lorenzo Trippa Gad Getz Donna S. Neuberg Irene M. Ghobrial Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant |
| description |
Multiple myeloma (MM) is treated with induction chemotherapy, autologous stem cell transplant (ASCT) and long-term immunomodulatory drug (IMiD) maintenance. Here, the authors show that the presence of clonal haematopoiesis of indeterminate potential (CHIP) at time of ASCT is associated with adverse outcomes in MM patients. |
| format |
article |
| author |
Tarek H. Mouhieddine Adam S. Sperling Robert Redd Jihye Park Matthew Leventhal Christopher J. Gibson Salomon Manier Amin H. Nassar Marzia Capelletti Daisy Huynh Mark Bustoros Romanos Sklavenitis-Pistofidis Sabrin Tahri Kalvis Hornburg Henry Dumke Muhieddine M. Itani Cody J. Boehner Chia-Jen Liu Saud H. AlDubayan Brendan Reardon Eliezer M. Van Allen Jonathan J. Keats Chip Stewart Shaadi Mehr Daniel Auclair Robert L. Schlossman Nikhil C. Munshi Kenneth C. Anderson David P. Steensma Jacob P. Laubach Paul G. Richardson Jerome Ritz Benjamin L. Ebert Robert J. Soiffer Lorenzo Trippa Gad Getz Donna S. Neuberg Irene M. Ghobrial |
| author_facet |
Tarek H. Mouhieddine Adam S. Sperling Robert Redd Jihye Park Matthew Leventhal Christopher J. Gibson Salomon Manier Amin H. Nassar Marzia Capelletti Daisy Huynh Mark Bustoros Romanos Sklavenitis-Pistofidis Sabrin Tahri Kalvis Hornburg Henry Dumke Muhieddine M. Itani Cody J. Boehner Chia-Jen Liu Saud H. AlDubayan Brendan Reardon Eliezer M. Van Allen Jonathan J. Keats Chip Stewart Shaadi Mehr Daniel Auclair Robert L. Schlossman Nikhil C. Munshi Kenneth C. Anderson David P. Steensma Jacob P. Laubach Paul G. Richardson Jerome Ritz Benjamin L. Ebert Robert J. Soiffer Lorenzo Trippa Gad Getz Donna S. Neuberg Irene M. Ghobrial |
| author_sort |
Tarek H. Mouhieddine |
| title |
Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant |
| title_short |
Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant |
| title_full |
Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant |
| title_fullStr |
Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant |
| title_full_unstemmed |
Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant |
| title_sort |
clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/26a4f18ed00849e6bce820eacad6b32d |
| work_keys_str_mv |
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