Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content>

ABSTRACT The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community. Over the past decade, our understanding of how this yea...

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Autores principales:	Ryan Kean, Gordon Ramage
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	Candida antifungal resistance biofilms tolerance Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/26a53634015443a9b3763c7ec760007c
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spelling	oai:doaj.org-article:26a53634015443a9b3763c7ec760007c2021-11-15T15:22:27ZCombined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content>10.1128/mSphere.00458-192379-5042https://doaj.org/article/26a53634015443a9b3763c7ec760007c2019-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00458-19https://doaj.org/toc/2379-5042ABSTRACT The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community. Over the past decade, our understanding of how this yeast has spread globally, its clinical importance, and how it tolerates and resists antifungal agents has expanded. This review highlights the clinical importance of antifungal resistance in C. auris and explores our current understanding of the mechanisms associated with azole, polyene, and echinocandin resistance. We also discuss the impact of phenotypic tolerance, with particular emphasis on biofilm-mediated resistance, and present new pipelines of antifungal drugs that promise new hope in the management of C. auris infection.Ryan KeanGordon RamageAmerican Society for MicrobiologyarticleCandidaantifungal resistancebiofilmstoleranceMicrobiologyQR1-502ENmSphere, Vol 4, Iss 4 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Candida antifungal resistance biofilms tolerance Microbiology QR1-502
spellingShingle	Candida antifungal resistance biofilms tolerance Microbiology QR1-502 Ryan Kean Gordon Ramage Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content>
description	ABSTRACT The enigmatic yeast Candida auris has emerged over the last decade and rapidly penetrated our consciousness. The global threat from this multidrug-resistant yeast has generated a call to arms from within the medical mycology community. Over the past decade, our understanding of how this yeast has spread globally, its clinical importance, and how it tolerates and resists antifungal agents has expanded. This review highlights the clinical importance of antifungal resistance in C. auris and explores our current understanding of the mechanisms associated with azole, polyene, and echinocandin resistance. We also discuss the impact of phenotypic tolerance, with particular emphasis on biofilm-mediated resistance, and present new pipelines of antifungal drugs that promise new hope in the management of C. auris infection.
format	article
author	Ryan Kean Gordon Ramage
author_facet	Ryan Kean Gordon Ramage
author_sort	Ryan Kean
title	Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content>
title_short	Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content>
title_full	Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content>
title_fullStr	Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content>
title_full_unstemmed	Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content>
title_sort	combined antifungal resistance and biofilm tolerance: the global threat of <named-content content-type="genus-species">candida auris</named-content>
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/26a53634015443a9b3763c7ec760007c
work_keys_str_mv	AT ryankean combinedantifungalresistanceandbiofilmtolerancetheglobalthreatofnamedcontentcontenttypegenusspeciescandidaaurisnamedcontent AT gordonramage combinedantifungalresistanceandbiofilmtolerancetheglobalthreatofnamedcontentcontenttypegenusspeciescandidaaurisnamedcontent
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Combined Antifungal Resistance and Biofilm Tolerance: the Global Threat of <named-content content-type="genus-species">Candida auris</named-content>

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