Dpath software reveals hierarchical haemato-endothelial lineages of Etv2 progenitors based on single-cell transcriptome analysis

Single-cell RNA sequencing has enabled great advances in understanding developmental biology but reconstructing cellular lineages from this data remains challenging. Here the authors develop an algorithm,dpath, which models the lineage relationships of underlying single cells based on single cell RN...

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Autores principales:	Wuming Gong, Tara L. Rasmussen, Bhairab N. Singh, Naoko Koyano-Nakagawa, Wei Pan, Daniel J. Garry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26a6e5fde8f54559bc2ee0105ac8cd5d
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spelling	oai:doaj.org-article:26a6e5fde8f54559bc2ee0105ac8cd5d2021-12-02T14:41:19ZDpath software reveals hierarchical haemato-endothelial lineages of Etv2 progenitors based on single-cell transcriptome analysis10.1038/ncomms143622041-1723https://doaj.org/article/26a6e5fde8f54559bc2ee0105ac8cd5d2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14362https://doaj.org/toc/2041-1723Single-cell RNA sequencing has enabled great advances in understanding developmental biology but reconstructing cellular lineages from this data remains challenging. Here the authors develop an algorithm,dpath, which models the lineage relationships of underlying single cells based on single cell RNA seq data and apply it to study lineage progression of Etv2 expressing progenitors.Wuming GongTara L. RasmussenBhairab N. SinghNaoko Koyano-NakagawaWei PanDaniel J. GarryNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wuming Gong Tara L. Rasmussen Bhairab N. Singh Naoko Koyano-Nakagawa Wei Pan Daniel J. Garry Dpath software reveals hierarchical haemato-endothelial lineages of Etv2 progenitors based on single-cell transcriptome analysis
description	Single-cell RNA sequencing has enabled great advances in understanding developmental biology but reconstructing cellular lineages from this data remains challenging. Here the authors develop an algorithm,dpath, which models the lineage relationships of underlying single cells based on single cell RNA seq data and apply it to study lineage progression of Etv2 expressing progenitors.
format	article
author	Wuming Gong Tara L. Rasmussen Bhairab N. Singh Naoko Koyano-Nakagawa Wei Pan Daniel J. Garry
author_facet	Wuming Gong Tara L. Rasmussen Bhairab N. Singh Naoko Koyano-Nakagawa Wei Pan Daniel J. Garry
author_sort	Wuming Gong
title	Dpath software reveals hierarchical haemato-endothelial lineages of Etv2 progenitors based on single-cell transcriptome analysis
title_short	Dpath software reveals hierarchical haemato-endothelial lineages of Etv2 progenitors based on single-cell transcriptome analysis
title_full	Dpath software reveals hierarchical haemato-endothelial lineages of Etv2 progenitors based on single-cell transcriptome analysis
title_fullStr	Dpath software reveals hierarchical haemato-endothelial lineages of Etv2 progenitors based on single-cell transcriptome analysis
title_full_unstemmed	Dpath software reveals hierarchical haemato-endothelial lineages of Etv2 progenitors based on single-cell transcriptome analysis
title_sort	dpath software reveals hierarchical haemato-endothelial lineages of etv2 progenitors based on single-cell transcriptome analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/26a6e5fde8f54559bc2ee0105ac8cd5d
work_keys_str_mv	AT wuminggong dpathsoftwarerevealshierarchicalhaematoendotheliallineagesofetv2progenitorsbasedonsinglecelltranscriptomeanalysis AT taralrasmussen dpathsoftwarerevealshierarchicalhaematoendotheliallineagesofetv2progenitorsbasedonsinglecelltranscriptomeanalysis AT bhairabnsingh dpathsoftwarerevealshierarchicalhaematoendotheliallineagesofetv2progenitorsbasedonsinglecelltranscriptomeanalysis AT naokokoyanonakagawa dpathsoftwarerevealshierarchicalhaematoendotheliallineagesofetv2progenitorsbasedonsinglecelltranscriptomeanalysis AT weipan dpathsoftwarerevealshierarchicalhaematoendotheliallineagesofetv2progenitorsbasedonsinglecelltranscriptomeanalysis AT danieljgarry dpathsoftwarerevealshierarchicalhaematoendotheliallineagesofetv2progenitorsbasedonsinglecelltranscriptomeanalysis
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Dpath software reveals hierarchical haemato-endothelial lineages of Etv2 progenitors based on single-cell transcriptome analysis

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