CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages

Dendritic cells (DC) are important regulators of both innate and adaptive immunity, but how the DC pool is homeostatically maintained in vivo is unclear. Here the authors show that combined deficiency of FLT3 and CSF1R impedes the differentiation of spleen macrophages of embryonic origin that are re...

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Autores principales:	Gulce Itir Percin, Jiri Eitler, Andrea Kranz, Jun Fu, Jeffrey W. Pollard, Ronald Naumann, Claudia Waskow
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26aa34f35e234e4680c9e47817ebef45
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spelling	oai:doaj.org-article:26aa34f35e234e4680c9e47817ebef452021-12-02T16:50:05ZCSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages10.1038/s41467-018-07685-x2041-1723https://doaj.org/article/26aa34f35e234e4680c9e47817ebef452018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07685-xhttps://doaj.org/toc/2041-1723Dendritic cells (DC) are important regulators of both innate and adaptive immunity, but how the DC pool is homeostatically maintained in vivo is unclear. Here the authors show that combined deficiency of FLT3 and CSF1R impedes the differentiation of spleen macrophages of embryonic origin that are required for DC homeostasis.Gulce Itir PercinJiri EitlerAndrea KranzJun FuJeffrey W. PollardRonald NaumannClaudia WaskowNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gulce Itir Percin Jiri Eitler Andrea Kranz Jun Fu Jeffrey W. Pollard Ronald Naumann Claudia Waskow CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages
description	Dendritic cells (DC) are important regulators of both innate and adaptive immunity, but how the DC pool is homeostatically maintained in vivo is unclear. Here the authors show that combined deficiency of FLT3 and CSF1R impedes the differentiation of spleen macrophages of embryonic origin that are required for DC homeostasis.
format	article
author	Gulce Itir Percin Jiri Eitler Andrea Kranz Jun Fu Jeffrey W. Pollard Ronald Naumann Claudia Waskow
author_facet	Gulce Itir Percin Jiri Eitler Andrea Kranz Jun Fu Jeffrey W. Pollard Ronald Naumann Claudia Waskow
author_sort	Gulce Itir Percin
title	CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages
title_short	CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages
title_full	CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages
title_fullStr	CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages
title_full_unstemmed	CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages
title_sort	csf1r regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/26aa34f35e234e4680c9e47817ebef45
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CSF1R regulates the dendritic cell pool size in adult mice via embryo-derived tissue-resident macrophages

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