Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.

MACC1 gene is a newly discovered gene and plays an important role in the metastasis of colorectal cancer (CRC). The objective of this study was to investigate whether MACC1 is an independent factor associated with lymphatic metastasis in CRC patients. We analyzed the association between MACC1 expres...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zheying Zhang, Huijie Jia, Yuhang Wang, Baoshun Du, Jiateng Zhong
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/26ae0a6d3e294f758133776429b9965e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:26ae0a6d3e294f758133776429b9965e
record_format	dspace
spelling	oai:doaj.org-article:26ae0a6d3e294f758133776429b9965e2021-12-02T20:18:48ZAssociation of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.1932-620310.1371/journal.pone.0255489https://doaj.org/article/26ae0a6d3e294f758133776429b9965e2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255489https://doaj.org/toc/1932-6203MACC1 gene is a newly discovered gene and plays an important role in the metastasis of colorectal cancer (CRC). The objective of this study was to investigate whether MACC1 is an independent factor associated with lymphatic metastasis in CRC patients. We analyzed the association between MACC1 expression and lymphatic metastasis in a nested case-control study including 99 cases and 198 matched controls in CRC patients, assessed from August 2001 to March 2015. Cases were defined as lymphatic metastasis and non-lymphatic metastasis according to AJCC TNM stages; for each case, two age-matched control without lymphatic and distant metastasis was randomly selected from the study participants. Demographic, variables about metastasis and MACC1 expression were collected. In multivariate analysis, the OR (95% CI) of MACC1 expression was 1.5 (1.1 to 2.0) in patients with lymphatic metastasis versus non-lymphatic metastasis after adjusting all variables. After adjustment for all variables and age stratification, MACC1 expression was found to be an independent risk factor for lymph node metastasis in the middle-aged group (OR 2.1, 95%CI 1.1-4.0). A nonlinear relationship between MACC1 expression and 64-75 age group was observed. The probability of metastasis slightly increased with the MACC1 level lower than turning point 1.4. At the same time, the probability of lymphatic metastasis was obviously increased even after adjusting all variables when MACC1 level higher than 1.4 (OR 11.2, 95% CI 1.5-81.5; p = 0.017) in the middle age group. The expression of MACC1 was not associated with lymphatic metastasis in populations younger than 64 or older than 75. The results demonstrates that increased MACC1 level in 64-75 age group might be associated with lymphatic metastasis in CRC patients.Zheying ZhangHuijie JiaYuhang WangBaoshun DuJiateng ZhongPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255489 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zheying Zhang Huijie Jia Yuhang Wang Baoshun Du Jiateng Zhong Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.
description	MACC1 gene is a newly discovered gene and plays an important role in the metastasis of colorectal cancer (CRC). The objective of this study was to investigate whether MACC1 is an independent factor associated with lymphatic metastasis in CRC patients. We analyzed the association between MACC1 expression and lymphatic metastasis in a nested case-control study including 99 cases and 198 matched controls in CRC patients, assessed from August 2001 to March 2015. Cases were defined as lymphatic metastasis and non-lymphatic metastasis according to AJCC TNM stages; for each case, two age-matched control without lymphatic and distant metastasis was randomly selected from the study participants. Demographic, variables about metastasis and MACC1 expression were collected. In multivariate analysis, the OR (95% CI) of MACC1 expression was 1.5 (1.1 to 2.0) in patients with lymphatic metastasis versus non-lymphatic metastasis after adjusting all variables. After adjustment for all variables and age stratification, MACC1 expression was found to be an independent risk factor for lymph node metastasis in the middle-aged group (OR 2.1, 95%CI 1.1-4.0). A nonlinear relationship between MACC1 expression and 64-75 age group was observed. The probability of metastasis slightly increased with the MACC1 level lower than turning point 1.4. At the same time, the probability of lymphatic metastasis was obviously increased even after adjusting all variables when MACC1 level higher than 1.4 (OR 11.2, 95% CI 1.5-81.5; p = 0.017) in the middle age group. The expression of MACC1 was not associated with lymphatic metastasis in populations younger than 64 or older than 75. The results demonstrates that increased MACC1 level in 64-75 age group might be associated with lymphatic metastasis in CRC patients.
format	article
author	Zheying Zhang Huijie Jia Yuhang Wang Baoshun Du Jiateng Zhong
author_facet	Zheying Zhang Huijie Jia Yuhang Wang Baoshun Du Jiateng Zhong
author_sort	Zheying Zhang
title	Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.
title_short	Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.
title_full	Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.
title_fullStr	Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.
title_full_unstemmed	Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.
title_sort	association of macc1 expression with lymphatic metastasis in colorectal cancer: a nested case-control study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/26ae0a6d3e294f758133776429b9965e
work_keys_str_mv	AT zheyingzhang associationofmacc1expressionwithlymphaticmetastasisincolorectalcanceranestedcasecontrolstudy AT huijiejia associationofmacc1expressionwithlymphaticmetastasisincolorectalcanceranestedcasecontrolstudy AT yuhangwang associationofmacc1expressionwithlymphaticmetastasisincolorectalcanceranestedcasecontrolstudy AT baoshundu associationofmacc1expressionwithlymphaticmetastasisincolorectalcanceranestedcasecontrolstudy AT jiatengzhong associationofmacc1expressionwithlymphaticmetastasisincolorectalcanceranestedcasecontrolstudy
_version_	1718374214899073024

Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.

Ejemplares similares