On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation

Sopp et al describe an approach, which exploits the tailpiece of the naturally multimeric IgM to augment hexamerisation of IgG. Their approach provides a newly engineered format of antibodies for promoting hexamerisation and enhanced complement-dependent cytotoxicity only when cell surface bound.

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Autores principales:	Joshua M. Sopp, Shirley J. Peters, Tania F. Rowley, Robert J. Oldham, Sonya James, Ian Mockridge, Ruth R. French, Alison Turner, Stephen A. Beers, David P. Humphreys, Mark S. Cragg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/26ae9b2bf9f1415f9ed90dfd8fef8201
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spelling	oai:doaj.org-article:26ae9b2bf9f1415f9ed90dfd8fef82012021-12-02T16:38:24ZOn-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation10.1038/s42003-021-02513-32399-3642https://doaj.org/article/26ae9b2bf9f1415f9ed90dfd8fef82012021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02513-3https://doaj.org/toc/2399-3642Sopp et al describe an approach, which exploits the tailpiece of the naturally multimeric IgM to augment hexamerisation of IgG. Their approach provides a newly engineered format of antibodies for promoting hexamerisation and enhanced complement-dependent cytotoxicity only when cell surface bound.Joshua M. SoppShirley J. PetersTania F. RowleyRobert J. OldhamSonya JamesIan MockridgeRuth R. FrenchAlison TurnerStephen A. BeersDavid P. HumphreysMark S. CraggNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Joshua M. Sopp Shirley J. Peters Tania F. Rowley Robert J. Oldham Sonya James Ian Mockridge Ruth R. French Alison Turner Stephen A. Beers David P. Humphreys Mark S. Cragg On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation
description	Sopp et al describe an approach, which exploits the tailpiece of the naturally multimeric IgM to augment hexamerisation of IgG. Their approach provides a newly engineered format of antibodies for promoting hexamerisation and enhanced complement-dependent cytotoxicity only when cell surface bound.
format	article
author	Joshua M. Sopp Shirley J. Peters Tania F. Rowley Robert J. Oldham Sonya James Ian Mockridge Ruth R. French Alison Turner Stephen A. Beers David P. Humphreys Mark S. Cragg
author_facet	Joshua M. Sopp Shirley J. Peters Tania F. Rowley Robert J. Oldham Sonya James Ian Mockridge Ruth R. French Alison Turner Stephen A. Beers David P. Humphreys Mark S. Cragg
author_sort	Joshua M. Sopp
title	On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation
title_short	On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation
title_full	On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation
title_fullStr	On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation
title_full_unstemmed	On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation
title_sort	on-target igg hexamerisation driven by a c-terminal igm tail-piece fusion variant confers augmented complement activation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/26ae9b2bf9f1415f9ed90dfd8fef8201
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On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation

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