Mismatch repair and repair of insertion/deletion loops in eukaryotic DNA

The mismatch repair (MMR) system detects non-Watson - Crick base pairs as well as the defects, appearing in course of DNA replication, and helps to eliminate them by catalyzing the excision of the defect-containing region of daughter DNA and its error-free resynthesis. Thus, MMR remarkably improves...

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Autores principales:	L. O. Gutsol, I. E. Egorova, S. F. Nepomnyashchikh, L. N. Minakina, M. V. Yas'ko
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	mmr mutsα или mutsβ mutlα pcna post-replication dna repair nobel prize in chemistry excision of bases mutsα or mutsβ dna-polymerase δ dna-ligase i Science Q
Acceso en línea:	https://doaj.org/article/26b00d293ecb49de82f68ea66ae83a70
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spelling	oai:doaj.org-article:26b00d293ecb49de82f68ea66ae83a702021-11-23T06:14:35ZMismatch repair and repair of insertion/deletion loops in eukaryotic DNA2541-94202587-959610.12737/21614https://doaj.org/article/26b00d293ecb49de82f68ea66ae83a702016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/230https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The mismatch repair (MMR) system detects non-Watson - Crick base pairs as well as the defects, appearing in course of DNA replication, and helps to eliminate them by catalyzing the excision of the defect-containing region of daughter DNA and its error-free resynthesis. Thus, MMR remarkably improves the fidelity of replication. After separation, both strands contain non-repairable damages and the mismatches may generate DnA mutation in 50 % of cell progeny after next replication. MMR dysfunction causes surge of mutation rate, abnormal recombination, and cancer in humans and animals. Therefore, the main MMR efficiency parameter is mismatch correction before the next replication cycle. Mismatch detection is made by the MSH2 protein, which forms a heterodimer with either MSH6 or MSH3 (Mut S), depending on the damage (MSH6 is needed for the amendment of single base mispairs, whereas both MSH3 and MSH6 can correct IDLs). A heterodimer of MLH1 and PMS2 (Mut L) controls the interaction between the mismatch-detecting complex of proteins and other proteins essential for MMR, including exonuclease 1, helicase, nuclear antigen of proliferating cells, single-stranded DNA-binding protein and DNA polymerases δ and ε. MLH1 can form a heterodimer with two additional proteins - MLH3 and PMS1. PMS2 is required for the correction of single based mismatches, and PMS2 and MLH3 contribute to the correction of IDLs. The Nobel Prize in Chemistry 2015 was awarded for the studies of DNA repair, i.a. MMR.L. O. GutsolI. E. EgorovaS. F. NepomnyashchikhL. N. MinakinaM. V. Yas'koScientific Сentre for Family Health and Human Reproduction Problemsarticlemmrmutsα или mutsβmutlαpcnammrpost-replication dna repairnobel prize in chemistryexcision of basesmutsα or mutsβmutlαpcnadna-polymerase δdna-ligase iScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(1), Pp 71-75 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	mmr mutsα или mutsβ mutlα pcna mmr post-replication dna repair nobel prize in chemistry excision of bases mutsα or mutsβ mutlα pcna dna-polymerase δ dna-ligase i Science Q
spellingShingle	mmr mutsα или mutsβ mutlα pcna mmr post-replication dna repair nobel prize in chemistry excision of bases mutsα or mutsβ mutlα pcna dna-polymerase δ dna-ligase i Science Q L. O. Gutsol I. E. Egorova S. F. Nepomnyashchikh L. N. Minakina M. V. Yas'ko Mismatch repair and repair of insertion/deletion loops in eukaryotic DNA
description	The mismatch repair (MMR) system detects non-Watson - Crick base pairs as well as the defects, appearing in course of DNA replication, and helps to eliminate them by catalyzing the excision of the defect-containing region of daughter DNA and its error-free resynthesis. Thus, MMR remarkably improves the fidelity of replication. After separation, both strands contain non-repairable damages and the mismatches may generate DnA mutation in 50 % of cell progeny after next replication. MMR dysfunction causes surge of mutation rate, abnormal recombination, and cancer in humans and animals. Therefore, the main MMR efficiency parameter is mismatch correction before the next replication cycle. Mismatch detection is made by the MSH2 protein, which forms a heterodimer with either MSH6 or MSH3 (Mut S), depending on the damage (MSH6 is needed for the amendment of single base mispairs, whereas both MSH3 and MSH6 can correct IDLs). A heterodimer of MLH1 and PMS2 (Mut L) controls the interaction between the mismatch-detecting complex of proteins and other proteins essential for MMR, including exonuclease 1, helicase, nuclear antigen of proliferating cells, single-stranded DNA-binding protein and DNA polymerases δ and ε. MLH1 can form a heterodimer with two additional proteins - MLH3 and PMS1. PMS2 is required for the correction of single based mismatches, and PMS2 and MLH3 contribute to the correction of IDLs. The Nobel Prize in Chemistry 2015 was awarded for the studies of DNA repair, i.a. MMR.
format	article
author	L. O. Gutsol I. E. Egorova S. F. Nepomnyashchikh L. N. Minakina M. V. Yas'ko
author_facet	L. O. Gutsol I. E. Egorova S. F. Nepomnyashchikh L. N. Minakina M. V. Yas'ko
author_sort	L. O. Gutsol
title	Mismatch repair and repair of insertion/deletion loops in eukaryotic DNA
title_short	Mismatch repair and repair of insertion/deletion loops in eukaryotic DNA
title_full	Mismatch repair and repair of insertion/deletion loops in eukaryotic DNA
title_fullStr	Mismatch repair and repair of insertion/deletion loops in eukaryotic DNA
title_full_unstemmed	Mismatch repair and repair of insertion/deletion loops in eukaryotic DNA
title_sort	mismatch repair and repair of insertion/deletion loops in eukaryotic dna
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/26b00d293ecb49de82f68ea66ae83a70
work_keys_str_mv	AT logutsol mismatchrepairandrepairofinsertiondeletionloopsineukaryoticdna AT ieegorova mismatchrepairandrepairofinsertiondeletionloopsineukaryoticdna AT sfnepomnyashchikh mismatchrepairandrepairofinsertiondeletionloopsineukaryoticdna AT lnminakina mismatchrepairandrepairofinsertiondeletionloopsineukaryoticdna AT mvyasko mismatchrepairandrepairofinsertiondeletionloopsineukaryoticdna
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Mismatch repair and repair of insertion/deletion loops in eukaryotic DNA

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