Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2

Context: Mentha longifolia L. (Lamiaceae), a traditional medicinal herb, has been highly valued for exhibiting antimicrobial, antioxidant and antispasmodic properties. Objective: For the first time, the synergetic anti-inflammatory effects of deuterium depleted water (DDW) and M. longifolia essentia...

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Autores principales:	Azadeh Rasooli, Faezeh Fatemi, Reza Hajihosseini, Atoosa Vaziri, Kambiz Akbarzadeh, Mohammad Reza Mohammadi Malayeri, Salome Dini, Maria Foroutanrad
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	natural products anti-inflammation oxidative stress/antioxidant parameters gene expression histopathology prostaglandin e2 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/26b00f2ab8644b65893515fac6a9b134
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spelling	oai:doaj.org-article:26b00f2ab8644b65893515fac6a9b1342021-11-17T14:21:55ZSynergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-21388-02091744-511610.1080/13880209.2018.1563622https://doaj.org/article/26b00f2ab8644b65893515fac6a9b1342019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2018.1563622https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Mentha longifolia L. (Lamiaceae), a traditional medicinal herb, has been highly valued for exhibiting antimicrobial, antioxidant and antispasmodic properties. Objective: For the first time, the synergetic anti-inflammatory effects of deuterium depleted water (DDW) and M. longifolia essential oils (ML) were investigated in experimental sepsis. Materials and methods: Fifty Wistar rats were divided into 5 groups (n = 10): negative control (laparotomy), CLP, treatment groups including the combination of DDWs (15 and 30 ppm) and ML (100 mg/kg b.w) and indomethacin. At 24 h after CLP induction, lipid peroxidation (LP), glutathione (GSH), glutathione in S-transferases (GST), ferric reducing ability of plasma (FRAP), myeloperoxidase (MPO), prostaglandin E2 (PGE2), and COX-2 expression were determined in the plasma and liver tissues. Results: Compared with the CLP group, the administration of DDWs and ML significantly (p < 0.05) prevented the increase of LP, COX-2 and PGE2 levels and liver enzymes. Additionally, the decreased levels of FRAP and GSH induced by sepsis were remarkably (p < 0.05) risen by the administration of DDWs and ML in comparison to the CLP group. However, no significant (p > 0.05) differences were observed regarding GST, ALP and bilirubin levels. Our results also proved the synergistic anti-inflammatory activities of the DDWs and ML. The anti-inflammatory effects of the DDWs and ML were confirmed by histopathological studies. Discussion and conclusions: The combination of DDWs and ML exerted synergistic anti-inflammatory activity against CLP-induced sepsis possibly through modulating oxidative stress/antioxidant parameters.Azadeh RasooliFaezeh FatemiReza HajihosseiniAtoosa VaziriKambiz AkbarzadehMohammad Reza Mohammadi MalayeriSalome DiniMaria ForoutanradTaylor & Francis Grouparticlenatural productsanti-inflammationoxidative stress/antioxidant parametersgene expressionhistopathologyprostaglandin e2Therapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 125-132 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	natural products anti-inflammation oxidative stress/antioxidant parameters gene expression histopathology prostaglandin e2 Therapeutics. Pharmacology RM1-950
spellingShingle	natural products anti-inflammation oxidative stress/antioxidant parameters gene expression histopathology prostaglandin e2 Therapeutics. Pharmacology RM1-950 Azadeh Rasooli Faezeh Fatemi Reza Hajihosseini Atoosa Vaziri Kambiz Akbarzadeh Mohammad Reza Mohammadi Malayeri Salome Dini Maria Foroutanrad Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2
description	Context: Mentha longifolia L. (Lamiaceae), a traditional medicinal herb, has been highly valued for exhibiting antimicrobial, antioxidant and antispasmodic properties. Objective: For the first time, the synergetic anti-inflammatory effects of deuterium depleted water (DDW) and M. longifolia essential oils (ML) were investigated in experimental sepsis. Materials and methods: Fifty Wistar rats were divided into 5 groups (n = 10): negative control (laparotomy), CLP, treatment groups including the combination of DDWs (15 and 30 ppm) and ML (100 mg/kg b.w) and indomethacin. At 24 h after CLP induction, lipid peroxidation (LP), glutathione (GSH), glutathione in S-transferases (GST), ferric reducing ability of plasma (FRAP), myeloperoxidase (MPO), prostaglandin E2 (PGE2), and COX-2 expression were determined in the plasma and liver tissues. Results: Compared with the CLP group, the administration of DDWs and ML significantly (p < 0.05) prevented the increase of LP, COX-2 and PGE2 levels and liver enzymes. Additionally, the decreased levels of FRAP and GSH induced by sepsis were remarkably (p < 0.05) risen by the administration of DDWs and ML in comparison to the CLP group. However, no significant (p > 0.05) differences were observed regarding GST, ALP and bilirubin levels. Our results also proved the synergistic anti-inflammatory activities of the DDWs and ML. The anti-inflammatory effects of the DDWs and ML were confirmed by histopathological studies. Discussion and conclusions: The combination of DDWs and ML exerted synergistic anti-inflammatory activity against CLP-induced sepsis possibly through modulating oxidative stress/antioxidant parameters.
format	article
author	Azadeh Rasooli Faezeh Fatemi Reza Hajihosseini Atoosa Vaziri Kambiz Akbarzadeh Mohammad Reza Mohammadi Malayeri Salome Dini Maria Foroutanrad
author_facet	Azadeh Rasooli Faezeh Fatemi Reza Hajihosseini Atoosa Vaziri Kambiz Akbarzadeh Mohammad Reza Mohammadi Malayeri Salome Dini Maria Foroutanrad
author_sort	Azadeh Rasooli
title	Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2
title_short	Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2
title_full	Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2
title_fullStr	Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2
title_full_unstemmed	Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2
title_sort	synergistic effects of deuterium depleted water and mentha longifolia l. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/26b00f2ab8644b65893515fac6a9b134
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Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2

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