Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin
Cutaneous squamous cell carcinoma (cSCC) is a skin cancer that normally progresses from UV-induced actinic keratosis (AK). Here, the authors investigate the epigenomics of cSCC and highlight two distinct subclasses of AK and cSCC originating from distinct keratinocyte differentiation stages.
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Nature Portfolio
2018
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oai:doaj.org-article:26b413b8fcbb4405904d85c489f5f2a22021-12-02T15:34:03ZMethylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin10.1038/s41467-018-03025-12041-1723https://doaj.org/article/26b413b8fcbb4405904d85c489f5f2a22018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03025-1https://doaj.org/toc/2041-1723Cutaneous squamous cell carcinoma (cSCC) is a skin cancer that normally progresses from UV-induced actinic keratosis (AK). Here, the authors investigate the epigenomics of cSCC and highlight two distinct subclasses of AK and cSCC originating from distinct keratinocyte differentiation stages.Manuel Rodríguez-ParedesFelix BormannGünter RaddatzJulian GutekunstCarlota Lucena-PorcelFlorian KöhlerElisabeth WurzerKatrin SchmidtStefan GallinatHorst WenckJoachim Röwert-HuberEvgeniya DenisovaLars FeuerbachJeongbin ParkBenedikt BrorsEsther HerpelIngo NindlThomas G. HofmannMarc WinnefeldFrank LykoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Manuel Rodríguez-Paredes Felix Bormann Günter Raddatz Julian Gutekunst Carlota Lucena-Porcel Florian Köhler Elisabeth Wurzer Katrin Schmidt Stefan Gallinat Horst Wenck Joachim Röwert-Huber Evgeniya Denisova Lars Feuerbach Jeongbin Park Benedikt Brors Esther Herpel Ingo Nindl Thomas G. Hofmann Marc Winnefeld Frank Lyko Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin |
| description |
Cutaneous squamous cell carcinoma (cSCC) is a skin cancer that normally progresses from UV-induced actinic keratosis (AK). Here, the authors investigate the epigenomics of cSCC and highlight two distinct subclasses of AK and cSCC originating from distinct keratinocyte differentiation stages. |
| format |
article |
| author |
Manuel Rodríguez-Paredes Felix Bormann Günter Raddatz Julian Gutekunst Carlota Lucena-Porcel Florian Köhler Elisabeth Wurzer Katrin Schmidt Stefan Gallinat Horst Wenck Joachim Röwert-Huber Evgeniya Denisova Lars Feuerbach Jeongbin Park Benedikt Brors Esther Herpel Ingo Nindl Thomas G. Hofmann Marc Winnefeld Frank Lyko |
| author_facet |
Manuel Rodríguez-Paredes Felix Bormann Günter Raddatz Julian Gutekunst Carlota Lucena-Porcel Florian Köhler Elisabeth Wurzer Katrin Schmidt Stefan Gallinat Horst Wenck Joachim Röwert-Huber Evgeniya Denisova Lars Feuerbach Jeongbin Park Benedikt Brors Esther Herpel Ingo Nindl Thomas G. Hofmann Marc Winnefeld Frank Lyko |
| author_sort |
Manuel Rodríguez-Paredes |
| title |
Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin |
| title_short |
Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin |
| title_full |
Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin |
| title_fullStr |
Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin |
| title_full_unstemmed |
Methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin |
| title_sort |
methylation profiling identifies two subclasses of squamous cell carcinoma related to distinct cells of origin |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/26b413b8fcbb4405904d85c489f5f2a2 |
| work_keys_str_mv |
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