Selenium-Enriched Soy Protein Has Antioxidant Potential via Modulation of the NRF2-HO1 Signaling Pathway

Selenium (Se)-enriched proteins are an important dietary source of Se for humans; however, only a few Se-enriched proteins have been identified. In the present study, we tested for potential antioxidant activity by Se-enriched soy protein, both in vitro and in vivo. Se-enriched soy protein isolate (...

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Autores principales:	Xiaoli Zhao, Jinyan Gao, Astrid Hogenkamp, Leon M. J. Knippels, Johan Garssen, Jing Bai, Anshu Yang, Yong Wu, Hongbing Chen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Se Se-enriched soy protein antioxidant NRF2 antioxidant enzyme Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/26b457ecf7114a1e8dfdff5720e49feb
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spelling	oai:doaj.org-article:26b457ecf7114a1e8dfdff5720e49feb2021-11-25T17:32:28ZSelenium-Enriched Soy Protein Has Antioxidant Potential via Modulation of the NRF2-HO1 Signaling Pathway10.3390/foods101125422304-8158https://doaj.org/article/26b457ecf7114a1e8dfdff5720e49feb2021-10-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2542https://doaj.org/toc/2304-8158Selenium (Se)-enriched proteins are an important dietary source of Se for humans; however, only a few Se-enriched proteins have been identified. In the present study, we tested for potential antioxidant activity by Se-enriched soy protein, both in vitro and in vivo. Se-enriched soy protein isolate (S-SPI) was shown to have a higher free radical scavenging ability compared to ordinary soy protein isolate (O-SPI). Furthermore, Caco-2 cell viability was improved by S-SPI at low doses, whereas O-SPI did not. In addition, S-SPI was shown to inhibit oxidative stress via modulation of the NRF2-HO1 signaling pathway, upregulating the expression of downstream antioxidant enzymes (GPx, SOD). To further study the antioxidant capacity of S-SPI, BALB/c female mice were given oral gavages with 0.8 mL of S-SPI or O-SPI (5 g/kg/d, 20 g/kg/d and 40 g/kg/d) or saline as control. Hepatic GPx and SOD activity increased with increasing S-SPI dosage, but not with O-SPI. Taken together, our results suggest that Se-enriched soy protein has a high antioxidant ability and may be used as a dietary supplement for people with oxidative dam-age-mediated diseases.Xiaoli ZhaoJinyan GaoAstrid HogenkampLeon M. J. KnippelsJohan GarssenJing BaiAnshu YangYong WuHongbing ChenMDPI AGarticleSeSe-enriched soy proteinantioxidantNRF2antioxidant enzymeChemical technologyTP1-1185ENFoods, Vol 10, Iss 2542, p 2542 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Se Se-enriched soy protein antioxidant NRF2 antioxidant enzyme Chemical technology TP1-1185
spellingShingle	Se Se-enriched soy protein antioxidant NRF2 antioxidant enzyme Chemical technology TP1-1185 Xiaoli Zhao Jinyan Gao Astrid Hogenkamp Leon M. J. Knippels Johan Garssen Jing Bai Anshu Yang Yong Wu Hongbing Chen Selenium-Enriched Soy Protein Has Antioxidant Potential via Modulation of the NRF2-HO1 Signaling Pathway
description	Selenium (Se)-enriched proteins are an important dietary source of Se for humans; however, only a few Se-enriched proteins have been identified. In the present study, we tested for potential antioxidant activity by Se-enriched soy protein, both in vitro and in vivo. Se-enriched soy protein isolate (S-SPI) was shown to have a higher free radical scavenging ability compared to ordinary soy protein isolate (O-SPI). Furthermore, Caco-2 cell viability was improved by S-SPI at low doses, whereas O-SPI did not. In addition, S-SPI was shown to inhibit oxidative stress via modulation of the NRF2-HO1 signaling pathway, upregulating the expression of downstream antioxidant enzymes (GPx, SOD). To further study the antioxidant capacity of S-SPI, BALB/c female mice were given oral gavages with 0.8 mL of S-SPI or O-SPI (5 g/kg/d, 20 g/kg/d and 40 g/kg/d) or saline as control. Hepatic GPx and SOD activity increased with increasing S-SPI dosage, but not with O-SPI. Taken together, our results suggest that Se-enriched soy protein has a high antioxidant ability and may be used as a dietary supplement for people with oxidative dam-age-mediated diseases.
format	article
author	Xiaoli Zhao Jinyan Gao Astrid Hogenkamp Leon M. J. Knippels Johan Garssen Jing Bai Anshu Yang Yong Wu Hongbing Chen
author_facet	Xiaoli Zhao Jinyan Gao Astrid Hogenkamp Leon M. J. Knippels Johan Garssen Jing Bai Anshu Yang Yong Wu Hongbing Chen
author_sort	Xiaoli Zhao
title	Selenium-Enriched Soy Protein Has Antioxidant Potential via Modulation of the NRF2-HO1 Signaling Pathway
title_short	Selenium-Enriched Soy Protein Has Antioxidant Potential via Modulation of the NRF2-HO1 Signaling Pathway
title_full	Selenium-Enriched Soy Protein Has Antioxidant Potential via Modulation of the NRF2-HO1 Signaling Pathway
title_fullStr	Selenium-Enriched Soy Protein Has Antioxidant Potential via Modulation of the NRF2-HO1 Signaling Pathway
title_full_unstemmed	Selenium-Enriched Soy Protein Has Antioxidant Potential via Modulation of the NRF2-HO1 Signaling Pathway
title_sort	selenium-enriched soy protein has antioxidant potential via modulation of the nrf2-ho1 signaling pathway
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/26b457ecf7114a1e8dfdff5720e49feb
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Selenium-Enriched Soy Protein Has Antioxidant Potential via Modulation of the NRF2-HO1 Signaling Pathway

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