Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia

Chemerin is an adipokine often downregulated in tumours. Here the authors show that chemotherapy induces chemerin production by endothelial cells, leading to cachexia, and that VEGF ablation in myeloid cells prevents cachexia in a chemerin-dependent manner, and improves chemotherapeutic effects.

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Autores principales:	Ralph Klose, Ewelina Krzywinska, Magali Castells, Dagmar Gotthardt, Eva Maria Putz, Chahrazade Kantari-Mimoun, Naima Chikdene, Anna-Katharina Meinecke, Katrin Schrödter, Iris Helfrich, Joachim Fandrey, Veronika Sexl, Christian Stockmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26b59077ba8c4ef5af5427b06f0a12dc
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spelling	oai:doaj.org-article:26b59077ba8c4ef5af5427b06f0a12dc2021-12-02T15:34:31ZTargeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia10.1038/ncomms125282041-1723https://doaj.org/article/26b59077ba8c4ef5af5427b06f0a12dc2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12528https://doaj.org/toc/2041-1723Chemerin is an adipokine often downregulated in tumours. Here the authors show that chemotherapy induces chemerin production by endothelial cells, leading to cachexia, and that VEGF ablation in myeloid cells prevents cachexia in a chemerin-dependent manner, and improves chemotherapeutic effects.Ralph KloseEwelina KrzywinskaMagali CastellsDagmar GotthardtEva Maria PutzChahrazade Kantari-MimounNaima ChikdeneAnna-Katharina MeineckeKatrin SchrödterIris HelfrichJoachim FandreyVeronika SexlChristian StockmannNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ralph Klose Ewelina Krzywinska Magali Castells Dagmar Gotthardt Eva Maria Putz Chahrazade Kantari-Mimoun Naima Chikdene Anna-Katharina Meinecke Katrin Schrödter Iris Helfrich Joachim Fandrey Veronika Sexl Christian Stockmann Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia
description	Chemerin is an adipokine often downregulated in tumours. Here the authors show that chemotherapy induces chemerin production by endothelial cells, leading to cachexia, and that VEGF ablation in myeloid cells prevents cachexia in a chemerin-dependent manner, and improves chemotherapeutic effects.
format	article
author	Ralph Klose Ewelina Krzywinska Magali Castells Dagmar Gotthardt Eva Maria Putz Chahrazade Kantari-Mimoun Naima Chikdene Anna-Katharina Meinecke Katrin Schrödter Iris Helfrich Joachim Fandrey Veronika Sexl Christian Stockmann
author_facet	Ralph Klose Ewelina Krzywinska Magali Castells Dagmar Gotthardt Eva Maria Putz Chahrazade Kantari-Mimoun Naima Chikdene Anna-Katharina Meinecke Katrin Schrödter Iris Helfrich Joachim Fandrey Veronika Sexl Christian Stockmann
author_sort	Ralph Klose
title	Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia
title_short	Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia
title_full	Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia
title_fullStr	Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia
title_full_unstemmed	Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia
title_sort	targeting vegf-a in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/26b59077ba8c4ef5af5427b06f0a12dc
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Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia

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