Physical and Mental Fatigue in Subjects Recovered from COVID-19 Infection: A Case–Control Study

Physical and Mental Fatigue in Subjects Recovered from COVID-19 Infection: A Case–Control Study

Rehab Elanwar,1 Mona Hussein,2 Rehab Magdy,3 Ragaey A Eid,4 Ahmed Yassien,5 Ahmed S Abdelsattar,6 Laila A Alsharaway,7 Wael Fathy,8 Amr Hassan,9 Yasmine S Kamal9,10 1Clinical Neurophysiology, Neurodiagnostic Research Center, Beni-Suef University, Beni-Suef, Egypt; 2Department of Neurology, Beni-Suef...

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Autores principales: Elanwar R, Hussein M, Magdy R, Eid RA, Yassien A, Abdelsattar AS, Alsharaway LA, Fathy W, Hassan A, Kamal YS
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
covid-19
fatigue
covid-19 long-haulers
single fiber emg
ferritin
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/26b84b4d633644a48e5b24ed789a1265
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spelling oai:doaj.org-article:26b84b4d633644a48e5b24ed789a12652021-12-02T18:01:33ZPhysical and Mental Fatigue in Subjects Recovered from COVID-19 Infection: A Case–Control Study1178-2021https://doaj.org/article/26b84b4d633644a48e5b24ed789a12652021-06-01T00:00:00Zhttps://www.dovepress.com/physical-and-mental-fatigue-in-subjects-recovered-from-covid-19-infect-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Rehab Elanwar,1 Mona Hussein,2 Rehab Magdy,3 Ragaey A Eid,4 Ahmed Yassien,5 Ahmed S Abdelsattar,6 Laila A Alsharaway,7 Wael Fathy,8 Amr Hassan,9 Yasmine S Kamal9,10 1Clinical Neurophysiology, Neurodiagnostic Research Center, Beni-Suef University, Beni-Suef, Egypt; 2Department of Neurology, Beni-Suef University, Beni-Suef, Egypt; 3Department of Neurology, Cairo University, Cairo, Egypt; 4Department of Tropical Medicine, Beni-Suef University, Beni-Suef, Egypt; 5Department of Critical Care Medicine, Beni-Suef University, Beni-Suef, Egypt; 6Department of Internal Medicine, Beni-Suef University, Beni-Suef, Egypt; 7Department of Chest Diseases, Beni-Suef University, Beni-Suef, Egypt; 8Department of Anaesthesia, Surgical ICU and Pain Management, Beni-SuefUniversity, Beni-Suef, Egypt; 9Department of Neurology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt; 10Department of Neurology, Rashid Hospital, Dubai, United Arab EmiratesCorrespondence: Mona HusseinDepartment of Neurology, Beni-Suef University, Salah Salem Street, Beni-Suef, 62551, EgyptTel +20-10-0513-1318Email mona.neuro@yahoo.comPurpose: Much effort has been directed toward studying COVID-19 symptoms; however, the post–COVID-19 phase remains mysterious. The aim of this work was to conduct a clinical and neurophysiological evaluation of physical and mental fatigue in COVID-19 long-haulers and to study whether markers of COVID-19 severity are able to predict the likelihood of developing postinfectious fatigue syndrome (PIFS) in such patients.Patients and Methods: This case–control study was conducted on 46 COVID-19 long-haulers who met the criteria for PIFS and 46 recovered COVID-19 subjects without any residuals. Clinical assessment of fatigue was done using a fatigue questionnaire. Repetitive nerve stimulation and single-fiber electromyography were done after excluding neuropathy and myopathy.Results: The median value for physical fatigue was 4 (IQR 2– 7), while that for mental fatigue was 2 (IQR 0– 3). Each day’s increase in the period of COVID-19 illness increased the odds of PIFS in COVID-19 long-haulers 1.104-fold, and each unit increase in ferritin increased the odds of PIFS 1.006-fold. A significant decrement in at least one muscle was observed in 50% of patients. Patients with PIFS had significantly higher mean consecutive difference (MCD) in the extensor digitorum communis than the control group. There were statistically significant positive correlations between MCD values and physical, mental, and total fatigue scores.Conclusion: Higher ferritin levels and prolonged COVID-19 infection were independent predictors of PIFS in COVID-19 long-haulers. There was electrophysiological evidence of abnormalities in the peripheral portion of the motor unit in COVID-19 long-haulers with PIFS.Keywords: COVID-19, fatigue, COVID-19 long-haulers, single-fiber EMG, ferritinElanwar RHussein MMagdy REid RAYassien AAbdelsattar ASAlsharaway LAFathy WHassan AKamal YSDove Medical Pressarticlecovid-19fatiguecovid-19 long-haulerssingle fiber emgferritinNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2063-2071 (2021)
institution DOAJ
collection DOAJ
language EN
topic covid-19
fatigue
covid-19 long-haulers
single fiber emg
ferritin
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle covid-19
fatigue
covid-19 long-haulers
single fiber emg
ferritin
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Elanwar R
Hussein M
Magdy R
Eid RA
Yassien A
Abdelsattar AS
Alsharaway LA
Fathy W
Hassan A
Kamal YS
Physical and Mental Fatigue in Subjects Recovered from COVID-19 Infection: A Case–Control Study
description Rehab Elanwar,1 Mona Hussein,2 Rehab Magdy,3 Ragaey A Eid,4 Ahmed Yassien,5 Ahmed S Abdelsattar,6 Laila A Alsharaway,7 Wael Fathy,8 Amr Hassan,9 Yasmine S Kamal9,10 1Clinical Neurophysiology, Neurodiagnostic Research Center, Beni-Suef University, Beni-Suef, Egypt; 2Department of Neurology, Beni-Suef University, Beni-Suef, Egypt; 3Department of Neurology, Cairo University, Cairo, Egypt; 4Department of Tropical Medicine, Beni-Suef University, Beni-Suef, Egypt; 5Department of Critical Care Medicine, Beni-Suef University, Beni-Suef, Egypt; 6Department of Internal Medicine, Beni-Suef University, Beni-Suef, Egypt; 7Department of Chest Diseases, Beni-Suef University, Beni-Suef, Egypt; 8Department of Anaesthesia, Surgical ICU and Pain Management, Beni-SuefUniversity, Beni-Suef, Egypt; 9Department of Neurology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt; 10Department of Neurology, Rashid Hospital, Dubai, United Arab EmiratesCorrespondence: Mona HusseinDepartment of Neurology, Beni-Suef University, Salah Salem Street, Beni-Suef, 62551, EgyptTel +20-10-0513-1318Email mona.neuro@yahoo.comPurpose: Much effort has been directed toward studying COVID-19 symptoms; however, the post–COVID-19 phase remains mysterious. The aim of this work was to conduct a clinical and neurophysiological evaluation of physical and mental fatigue in COVID-19 long-haulers and to study whether markers of COVID-19 severity are able to predict the likelihood of developing postinfectious fatigue syndrome (PIFS) in such patients.Patients and Methods: This case–control study was conducted on 46 COVID-19 long-haulers who met the criteria for PIFS and 46 recovered COVID-19 subjects without any residuals. Clinical assessment of fatigue was done using a fatigue questionnaire. Repetitive nerve stimulation and single-fiber electromyography were done after excluding neuropathy and myopathy.Results: The median value for physical fatigue was 4 (IQR 2– 7), while that for mental fatigue was 2 (IQR 0– 3). Each day’s increase in the period of COVID-19 illness increased the odds of PIFS in COVID-19 long-haulers 1.104-fold, and each unit increase in ferritin increased the odds of PIFS 1.006-fold. A significant decrement in at least one muscle was observed in 50% of patients. Patients with PIFS had significantly higher mean consecutive difference (MCD) in the extensor digitorum communis than the control group. There were statistically significant positive correlations between MCD values and physical, mental, and total fatigue scores.Conclusion: Higher ferritin levels and prolonged COVID-19 infection were independent predictors of PIFS in COVID-19 long-haulers. There was electrophysiological evidence of abnormalities in the peripheral portion of the motor unit in COVID-19 long-haulers with PIFS.Keywords: COVID-19, fatigue, COVID-19 long-haulers, single-fiber EMG, ferritin
format article
author Elanwar R
Hussein M
Magdy R
Eid RA
Yassien A
Abdelsattar AS
Alsharaway LA
Fathy W
Hassan A
Kamal YS
author_facet Elanwar R
Hussein M
Magdy R
Eid RA
Yassien A
Abdelsattar AS
Alsharaway LA
Fathy W
Hassan A
Kamal YS
author_sort Elanwar R
title Physical and Mental Fatigue in Subjects Recovered from COVID-19 Infection: A Case–Control Study
title_short Physical and Mental Fatigue in Subjects Recovered from COVID-19 Infection: A Case–Control Study
title_full Physical and Mental Fatigue in Subjects Recovered from COVID-19 Infection: A Case–Control Study
title_fullStr Physical and Mental Fatigue in Subjects Recovered from COVID-19 Infection: A Case–Control Study
title_full_unstemmed Physical and Mental Fatigue in Subjects Recovered from COVID-19 Infection: A Case–Control Study
title_sort physical and mental fatigue in subjects recovered from covid-19 infection: a case–control study
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/26b84b4d633644a48e5b24ed789a1265
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