Progress of Immune Checkpoint Inhibitors in the Treatment of Advanced Pulmonary Neuroendocrine Tumors
Pulmonary neuroendocrine tumors (PNETs) are a kind of epithelial tumors originating from pulmonary neuroendocrine cells, accounting for about 20% of primary lung tumors, including typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma. The morphologic an...
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2021
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oai:doaj.org-article:26b9b02e228d4918919f3705659d635d2021-11-19T06:49:15ZProgress of Immune Checkpoint Inhibitors
in the Treatment of Advanced Pulmonary Neuroendocrine Tumors1009-34191999-618710.3779/j.issn.1009-3419.2021.102.42https://doaj.org/article/26b9b02e228d4918919f3705659d635d2021-11-01T00:00:00Zhttp://dx.doi.org/10.3779/j.issn.1009-3419.2021.102.42https://doaj.org/toc/1009-3419https://doaj.org/toc/1999-6187Pulmonary neuroendocrine tumors (PNETs) are a kind of epithelial tumors originating from pulmonary neuroendocrine cells, accounting for about 20% of primary lung tumors, including typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma. The morphologic and clinical characteristics of these four types of PNETs are relatively highly heterogeneous. Immune checkpoint inhibitors (ICIs) have been shown robust antitumor activity in a variety of solid tumors. Treatment regimens of advanced PNETs have developed greatly in the past decade, but ICIs are still in their infancy in the field of PNETs. This review focuses on the landscape of current clinical trials and research as well as the situation of ICIs-related biomarkers in PNETs.Haoqing CHENQingwei MENGChinese Anti-Cancer Association; Chinese Antituberculosis Associationarticlepulmonary neuroendocrine tumorsimmune checkpoint inhibitorsbiomarkersimmnotherapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ZHChinese Journal of Lung Cancer, Vol 24, Iss 11, Pp 784-789 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
ZH |
| topic |
pulmonary neuroendocrine tumors immune checkpoint inhibitors biomarkers immnotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
pulmonary neuroendocrine tumors immune checkpoint inhibitors biomarkers immnotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Haoqing CHEN Qingwei MENG Progress of Immune Checkpoint Inhibitors in the Treatment of Advanced Pulmonary Neuroendocrine Tumors |
| description |
Pulmonary neuroendocrine tumors (PNETs) are a kind of epithelial tumors originating from pulmonary neuroendocrine cells, accounting for about 20% of primary lung tumors, including typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma. The morphologic and clinical characteristics of these four types of PNETs are relatively highly heterogeneous. Immune checkpoint inhibitors (ICIs) have been shown robust antitumor activity in a variety of solid tumors. Treatment regimens of advanced PNETs have developed greatly in the past decade, but ICIs are still in their infancy in the field of PNETs. This review focuses on the landscape of current clinical trials and research as well as the situation of ICIs-related biomarkers in PNETs. |
| format |
article |
| author |
Haoqing CHEN Qingwei MENG |
| author_facet |
Haoqing CHEN Qingwei MENG |
| author_sort |
Haoqing CHEN |
| title |
Progress of Immune Checkpoint Inhibitors
in the Treatment of Advanced Pulmonary Neuroendocrine Tumors |
| title_short |
Progress of Immune Checkpoint Inhibitors
in the Treatment of Advanced Pulmonary Neuroendocrine Tumors |
| title_full |
Progress of Immune Checkpoint Inhibitors
in the Treatment of Advanced Pulmonary Neuroendocrine Tumors |
| title_fullStr |
Progress of Immune Checkpoint Inhibitors
in the Treatment of Advanced Pulmonary Neuroendocrine Tumors |
| title_full_unstemmed |
Progress of Immune Checkpoint Inhibitors
in the Treatment of Advanced Pulmonary Neuroendocrine Tumors |
| title_sort |
progress of immune checkpoint inhibitors
in the treatment of advanced pulmonary neuroendocrine tumors |
| publisher |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| publishDate |
2021 |
| url |
https://doaj.org/article/26b9b02e228d4918919f3705659d635d |
| work_keys_str_mv |
AT haoqingchen progressofimmunecheckpointinhibitorsinthetreatmentofadvancedpulmonaryneuroendocrinetumors AT qingweimeng progressofimmunecheckpointinhibitorsinthetreatmentofadvancedpulmonaryneuroendocrinetumors |
| _version_ |
1718420300414058496 |