Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study

Ryosuke Kitahata,1 Shinichiro Nakajima,1–4 Hiroyuki Uchida,1,3 Tetsu Hayashida,5 Maiko Takahashi,5 Shintaro Nio,1 Jinichi Hirano,1 Maki Nagaoka,1 Takefumi Suzuki,1 Hiromitsu Jinno,6 Yuko Kitagawa,5 Masaru Mimura1 1Psychopharmacology Research Program, Department of Neuropsychiatry, School...

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Autores principales:	Kitahata R, Nakajima S, Uchida H, Hayashida T, Takahashi M, Nio S, Hirano J, Nagaoka M, Suzuki T, Jinno H, Kitagawa Y, Mimura M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	breast cancer chemotherapy subjective cognitive functions Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/26bda0e4e056482d92fc7b316c380682
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spelling	oai:doaj.org-article:26bda0e4e056482d92fc7b316c3806822021-12-02T02:47:30ZSelf-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study1178-2021https://doaj.org/article/26bda0e4e056482d92fc7b316c3806822017-10-01T00:00:00Zhttps://www.dovepress.com/self-rated-cognitive-functions-following-chemotherapy-in-patients-with-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ryosuke Kitahata,1 Shinichiro Nakajima,1–4 Hiroyuki Uchida,1,3 Tetsu Hayashida,5 Maiko Takahashi,5 Shintaro Nio,1 Jinichi Hirano,1 Maki Nagaoka,1 Takefumi Suzuki,1 Hiromitsu Jinno,6 Yuko Kitagawa,5 Masaru Mimura1 1Psychopharmacology Research Program, Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan; 2Multimodal Imaging Group – Research Imaging Centre, 3Geriatric Mental Health Division, Centre for Addiction and Mental Health, 4Department of Psychiatry, University of Toronto, Toronto, Canada; 5Department of Surgery, School of Medicine, Keio University, 6Department of Surgery, School of Medicine, Teikyo University, Tokyo, Japan Purpose: The purpose of the study was to evaluate subjective (self-rated), family-rated, and objective (researcher-rated) cognitive functions in patients with breast cancer after chemotherapy.Method: We conducted a prospective study to trace self-rated cognitive functions in 30 patients with breast cancer at the completion of chemotherapy (T0) and 6 months later (T1). Subjective cognitive functions were assessed with Cognitive Failures Questionnaire (CFQ), Dysexecutive Questionnaire (DEX-S), and Everyday Memory Checklist (EMC-S) for attention, executive function, and episodic memory, respectively. Their family members also completed DEX-I and EMC-I for executive function and episodic memory, respectively. We also examined objective cognitive functions. Self-rated cognitive functions were compared with the normative data. They were compared between T0 and T1. We calculated correlation coefficients between self-rated and other cognitive functions.Results: At T0, 6 (20.0%) and 2 (6.7%) participants showed higher DEX-S and EMC-S scores than the normative data, respectively, while no participant had abnormal CFQ scores. At T1, DEX-S and EMC-S scores were normalized in 3 (50.0%) and 2 (100.0%) participants, respectively. No participant showed increases in CFQ scores. No changes were found in objective cognitive functions from T0 to T1. DEX-S and DEX-I or EMC-S and EMC-I scores were correlated at both T0 and T1, which did not survive multiple corrections. There was no association between subjective and objective cognitive functions.Conclusion: Impairments in subjective cognition may be transient after chemotherapy in patients with breast cancer. Furthermore, patients and their families appear to share similar prospects on their cognitive functions. Keywords: breast cancer, chemotherapy, subjective cognitive functionsKitahata RNakajima SUchida HHayashida TTakahashi MNio SHirano JNagaoka MSuzuki TJinno HKitagawa YMimura MDove Medical Pressarticlebreast cancerchemotherapysubjective cognitive functionsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2489-2496 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer chemotherapy subjective cognitive functions Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	breast cancer chemotherapy subjective cognitive functions Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kitahata R Nakajima S Uchida H Hayashida T Takahashi M Nio S Hirano J Nagaoka M Suzuki T Jinno H Kitagawa Y Mimura M Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study
description	Ryosuke Kitahata,1 Shinichiro Nakajima,1–4 Hiroyuki Uchida,1,3 Tetsu Hayashida,5 Maiko Takahashi,5 Shintaro Nio,1 Jinichi Hirano,1 Maki Nagaoka,1 Takefumi Suzuki,1 Hiromitsu Jinno,6 Yuko Kitagawa,5 Masaru Mimura1 1Psychopharmacology Research Program, Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, Japan; 2Multimodal Imaging Group – Research Imaging Centre, 3Geriatric Mental Health Division, Centre for Addiction and Mental Health, 4Department of Psychiatry, University of Toronto, Toronto, Canada; 5Department of Surgery, School of Medicine, Keio University, 6Department of Surgery, School of Medicine, Teikyo University, Tokyo, Japan Purpose: The purpose of the study was to evaluate subjective (self-rated), family-rated, and objective (researcher-rated) cognitive functions in patients with breast cancer after chemotherapy.Method: We conducted a prospective study to trace self-rated cognitive functions in 30 patients with breast cancer at the completion of chemotherapy (T0) and 6 months later (T1). Subjective cognitive functions were assessed with Cognitive Failures Questionnaire (CFQ), Dysexecutive Questionnaire (DEX-S), and Everyday Memory Checklist (EMC-S) for attention, executive function, and episodic memory, respectively. Their family members also completed DEX-I and EMC-I for executive function and episodic memory, respectively. We also examined objective cognitive functions. Self-rated cognitive functions were compared with the normative data. They were compared between T0 and T1. We calculated correlation coefficients between self-rated and other cognitive functions.Results: At T0, 6 (20.0%) and 2 (6.7%) participants showed higher DEX-S and EMC-S scores than the normative data, respectively, while no participant had abnormal CFQ scores. At T1, DEX-S and EMC-S scores were normalized in 3 (50.0%) and 2 (100.0%) participants, respectively. No participant showed increases in CFQ scores. No changes were found in objective cognitive functions from T0 to T1. DEX-S and DEX-I or EMC-S and EMC-I scores were correlated at both T0 and T1, which did not survive multiple corrections. There was no association between subjective and objective cognitive functions.Conclusion: Impairments in subjective cognition may be transient after chemotherapy in patients with breast cancer. Furthermore, patients and their families appear to share similar prospects on their cognitive functions. Keywords: breast cancer, chemotherapy, subjective cognitive functions
format	article
author	Kitahata R Nakajima S Uchida H Hayashida T Takahashi M Nio S Hirano J Nagaoka M Suzuki T Jinno H Kitagawa Y Mimura M
author_facet	Kitahata R Nakajima S Uchida H Hayashida T Takahashi M Nio S Hirano J Nagaoka M Suzuki T Jinno H Kitagawa Y Mimura M
author_sort	Kitahata R
title	Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study
title_short	Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study
title_full	Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study
title_fullStr	Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study
title_full_unstemmed	Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study
title_sort	self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/26bda0e4e056482d92fc7b316c380682
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Self-rated cognitive functions following chemotherapy in patients with breast cancer: a 6-month prospective study

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