A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies

African trypanosome infections can persist for years, but immune evasion mechanisms are not fully understood. Here, Macleod et al. identify a trypanosome receptor for mammalian factor H, a negative regulator of the alternative complement pathway, that increases parasite transmission to tsetse flies.

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Autores principales:	Olivia J. S. Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J. Savill, Svenja Hester, Sophie Ravel, Jack D. Sunter, Camilla Trevor, Steven Rust, Tristan J. Vaughan, Ralph Minter, Shabaz Mohammed, Wendy Gibson, Martin C. Taylor, Matthew K. Higgins, Mark Carrington
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26bfcfd0e9cc483dae71e8f47f88e8ec
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spelling	oai:doaj.org-article:26bfcfd0e9cc483dae71e8f47f88e8ec2021-12-02T16:56:51ZA receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies10.1038/s41467-020-15125-y2041-1723https://doaj.org/article/26bfcfd0e9cc483dae71e8f47f88e8ec2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15125-yhttps://doaj.org/toc/2041-1723African trypanosome infections can persist for years, but immune evasion mechanisms are not fully understood. Here, Macleod et al. identify a trypanosome receptor for mammalian factor H, a negative regulator of the alternative complement pathway, that increases parasite transmission to tsetse flies.Olivia J. S. MacleodJean-Mathieu BartPaula MacGregorLori PeacockNicholas J. SavillSvenja HesterSophie RavelJack D. SunterCamilla TrevorSteven RustTristan J. VaughanRalph MinterShabaz MohammedWendy GibsonMartin C. TaylorMatthew K. HigginsMark CarringtonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Olivia J. S. Macleod Jean-Mathieu Bart Paula MacGregor Lori Peacock Nicholas J. Savill Svenja Hester Sophie Ravel Jack D. Sunter Camilla Trevor Steven Rust Tristan J. Vaughan Ralph Minter Shabaz Mohammed Wendy Gibson Martin C. Taylor Matthew K. Higgins Mark Carrington A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
description	African trypanosome infections can persist for years, but immune evasion mechanisms are not fully understood. Here, Macleod et al. identify a trypanosome receptor for mammalian factor H, a negative regulator of the alternative complement pathway, that increases parasite transmission to tsetse flies.
format	article
author	Olivia J. S. Macleod Jean-Mathieu Bart Paula MacGregor Lori Peacock Nicholas J. Savill Svenja Hester Sophie Ravel Jack D. Sunter Camilla Trevor Steven Rust Tristan J. Vaughan Ralph Minter Shabaz Mohammed Wendy Gibson Martin C. Taylor Matthew K. Higgins Mark Carrington
author_facet	Olivia J. S. Macleod Jean-Mathieu Bart Paula MacGregor Lori Peacock Nicholas J. Savill Svenja Hester Sophie Ravel Jack D. Sunter Camilla Trevor Steven Rust Tristan J. Vaughan Ralph Minter Shabaz Mohammed Wendy Gibson Martin C. Taylor Matthew K. Higgins Mark Carrington
author_sort	Olivia J. S. Macleod
title	A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
title_short	A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
title_full	A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
title_fullStr	A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
title_full_unstemmed	A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
title_sort	receptor for the complement regulator factor h increases transmission of trypanosomes to tsetse flies
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/26bfcfd0e9cc483dae71e8f47f88e8ec
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A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies

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