High myopia and macular vascular density: an optical coherence tomography angiography study

Abstract Objective To investigate whether there are differences inmacular vascular density (VD) between patients with high-myopia (HM) and those with non-high myopia (NHM) using Optical Coherence Tomography Angiography (OCTA). Method OCTA was performed on 35 eyes with HM with spherical equivalence (...

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Autores principales:	Yang Jiang, Shang Lou, Ying Li, Youxin Chen, Thomas Chengxuan Lu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/26c0c7a4b6964199a62e798cfc41da60
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spelling	oai:doaj.org-article:26c0c7a4b6964199a62e798cfc41da602021-11-28T12:42:22ZHigh myopia and macular vascular density: an optical coherence tomography angiography study10.1186/s12886-021-02156-21471-2415https://doaj.org/article/26c0c7a4b6964199a62e798cfc41da602021-11-01T00:00:00Zhttps://doi.org/10.1186/s12886-021-02156-2https://doaj.org/toc/1471-2415Abstract Objective To investigate whether there are differences inmacular vascular density (VD) between patients with high-myopia (HM) and those with non-high myopia (NHM) using Optical Coherence Tomography Angiography (OCTA). Method OCTA was performed on 35 eyes with HM with spherical equivalence (SE) > − 6.00D and 35 eyes with NHM with SE ≤ -6.00D. Vascular densities of the macula (overall macula, fovea, parafovea, superior hemi and inferior hemi) were measured in each of the superficial, deep and choriocapillaris layers of the retina. Results In the superficial retinal layer, overall macular VFD was significantly higher in the NHM compared to the HM group (51.27 ± 3.74 vs. 48.07 ± 5.69, p < 0.05). There were significant differences between the NHM and HM in parafovea (52.58 ± 5.78 vs. 49.4 ± 6.43, p < 0.05), superior-hemi (53.38 ± 4.03 vs 49.78 ± 6.84, p < 0.05) and inferior-hemi regions (53.49 ± 4.61 vs 49.05 ± 6.41, p < 0.05), but not in the fovea region. Similarly, in the deep retinal layer, overall macular VFD was significantly higher in the NHM group compared to the HM group (58.69 ± 2.46 vs. 56.90 ± 4.08, p < 0.05). There was significant differences between the HM and NHM in superior-hemi region (61.97 ± 2.68 vs. 60.08 ± 3.98, p < 0.05), but not in the fovea, parafovea, and inferior-hemi region. In the choriocapillaris, there was no difference in the overall macular VFD, nor any of the individual sectors between the HM and the NHM groups. Conclusion VFD in the superficial and deep retinal layers of the macula are significantly increased in the NHM compared to HM eyes. This is not the case in the choroidal capillary layers of the retina.Yang JiangShang LouYing LiYouxin ChenThomas Chengxuan LuBMCarticleOphthalmologyRE1-994ENBMC Ophthalmology, Vol 21, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Yang Jiang Shang Lou Ying Li Youxin Chen Thomas Chengxuan Lu High myopia and macular vascular density: an optical coherence tomography angiography study
description	Abstract Objective To investigate whether there are differences inmacular vascular density (VD) between patients with high-myopia (HM) and those with non-high myopia (NHM) using Optical Coherence Tomography Angiography (OCTA). Method OCTA was performed on 35 eyes with HM with spherical equivalence (SE) > − 6.00D and 35 eyes with NHM with SE ≤ -6.00D. Vascular densities of the macula (overall macula, fovea, parafovea, superior hemi and inferior hemi) were measured in each of the superficial, deep and choriocapillaris layers of the retina. Results In the superficial retinal layer, overall macular VFD was significantly higher in the NHM compared to the HM group (51.27 ± 3.74 vs. 48.07 ± 5.69, p < 0.05). There were significant differences between the NHM and HM in parafovea (52.58 ± 5.78 vs. 49.4 ± 6.43, p < 0.05), superior-hemi (53.38 ± 4.03 vs 49.78 ± 6.84, p < 0.05) and inferior-hemi regions (53.49 ± 4.61 vs 49.05 ± 6.41, p < 0.05), but not in the fovea region. Similarly, in the deep retinal layer, overall macular VFD was significantly higher in the NHM group compared to the HM group (58.69 ± 2.46 vs. 56.90 ± 4.08, p < 0.05). There was significant differences between the HM and NHM in superior-hemi region (61.97 ± 2.68 vs. 60.08 ± 3.98, p < 0.05), but not in the fovea, parafovea, and inferior-hemi region. In the choriocapillaris, there was no difference in the overall macular VFD, nor any of the individual sectors between the HM and the NHM groups. Conclusion VFD in the superficial and deep retinal layers of the macula are significantly increased in the NHM compared to HM eyes. This is not the case in the choroidal capillary layers of the retina.
format	article
author	Yang Jiang Shang Lou Ying Li Youxin Chen Thomas Chengxuan Lu
author_facet	Yang Jiang Shang Lou Ying Li Youxin Chen Thomas Chengxuan Lu
author_sort	Yang Jiang
title	High myopia and macular vascular density: an optical coherence tomography angiography study
title_short	High myopia and macular vascular density: an optical coherence tomography angiography study
title_full	High myopia and macular vascular density: an optical coherence tomography angiography study
title_fullStr	High myopia and macular vascular density: an optical coherence tomography angiography study
title_full_unstemmed	High myopia and macular vascular density: an optical coherence tomography angiography study
title_sort	high myopia and macular vascular density: an optical coherence tomography angiography study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/26c0c7a4b6964199a62e798cfc41da60
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High myopia and macular vascular density: an optical coherence tomography angiography study

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