Anti-inflammatory effect of pregabalin on acetic acid-induced colitis in the rats

Background and purpose: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease characterized by the inflammation of the intestine. The available medicinal treatments for IBD are not efficacious enough since they exert various adverse effects. Therefore, the search for new therapeutic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Azadeh Motavallian, Ehsan Zamani, Saba Bouzari, Farzam Rezaeyan, Paridokht Karimian, Mehdi Evazalipour
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2022
Materias:	experimental colitis; pregabalin; pro-inflammatory cytokines; rat. Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/26c2739823164b90973ab9a126da7a76
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:26c2739823164b90973ab9a126da7a76
record_format	dspace
spelling	oai:doaj.org-article:26c2739823164b90973ab9a126da7a762021-11-19T12:17:03ZAnti-inflammatory effect of pregabalin on acetic acid-induced colitis in the rats1735-53621735-941410.4103/1735-5362.329924https://doaj.org/article/26c2739823164b90973ab9a126da7a762022-01-01T00:00:00Zhttp://www.rpsjournal.net/article.asp?issn=1735-5362;year=2022;volume=17;issue=1;spage=35;epage=42;aulast=Motavallianhttps://doaj.org/toc/1735-5362https://doaj.org/toc/1735-9414Background and purpose: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease characterized by the inflammation of the intestine. The available medicinal treatments for IBD are not efficacious enough since they exert various adverse effects. Therefore, the search for new therapeutic agents should be continued. The present study aimed to assess the anti-inflammatory effects of pregabalin on acetic acid-induced colitis in rats. Experimental approach: Using 2 mL of 3% acetic acid solution, colitis was intra-rectally induced in rats. Animals were randomly divided into 6 groups including the normal group, colitis control group, pregabalin treatment groups (30, 50, and 100 mg/kg; i.p., respectively), and dexamethasone treatment group (1 mg/kg; i.p.). Macroscopic, microscopic, and biochemical (myeloperoxidase, tumor necrosis factor-alpha, interleukin-6, and interleukin-1 beta) examinations were used to evaluate the efficacy of pregabalin in the inflamed colon. Findings/Results: All the applied doses of pregabalin significantly decreased the severity of macroscopic and microscopic colonic damages including ulcer severity, ulcer area, percentage of necrosis, and total colitis index compared to the colitis control group. These results were confirmed by the reduced colonic concentration of tumor necrosis factor-alpha, interleukin-6, interleukin-1 beta, and myeloperoxidase activity. Conclusion and implications: Results of this study indicated that pregabalin administration has beneficial effects upon the treatment of experimental colitis, which might be partly due to its anti-inflammatory properties.Azadeh MotavallianEhsan ZamaniSaba BouzariFarzam RezaeyanParidokht KarimianMehdi EvazalipourWolters Kluwer Medknow Publicationsarticleexperimental colitis; pregabalin; pro-inflammatory cytokines; rat.Pharmacy and materia medicaRS1-441ENResearch in Pharmaceutical Sciences, Vol 17, Iss 1, Pp 35-42 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	experimental colitis; pregabalin; pro-inflammatory cytokines; rat. Pharmacy and materia medica RS1-441
spellingShingle	experimental colitis; pregabalin; pro-inflammatory cytokines; rat. Pharmacy and materia medica RS1-441 Azadeh Motavallian Ehsan Zamani Saba Bouzari Farzam Rezaeyan Paridokht Karimian Mehdi Evazalipour Anti-inflammatory effect of pregabalin on acetic acid-induced colitis in the rats
description	Background and purpose: Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease characterized by the inflammation of the intestine. The available medicinal treatments for IBD are not efficacious enough since they exert various adverse effects. Therefore, the search for new therapeutic agents should be continued. The present study aimed to assess the anti-inflammatory effects of pregabalin on acetic acid-induced colitis in rats. Experimental approach: Using 2 mL of 3% acetic acid solution, colitis was intra-rectally induced in rats. Animals were randomly divided into 6 groups including the normal group, colitis control group, pregabalin treatment groups (30, 50, and 100 mg/kg; i.p., respectively), and dexamethasone treatment group (1 mg/kg; i.p.). Macroscopic, microscopic, and biochemical (myeloperoxidase, tumor necrosis factor-alpha, interleukin-6, and interleukin-1 beta) examinations were used to evaluate the efficacy of pregabalin in the inflamed colon. Findings/Results: All the applied doses of pregabalin significantly decreased the severity of macroscopic and microscopic colonic damages including ulcer severity, ulcer area, percentage of necrosis, and total colitis index compared to the colitis control group. These results were confirmed by the reduced colonic concentration of tumor necrosis factor-alpha, interleukin-6, interleukin-1 beta, and myeloperoxidase activity. Conclusion and implications: Results of this study indicated that pregabalin administration has beneficial effects upon the treatment of experimental colitis, which might be partly due to its anti-inflammatory properties.
format	article
author	Azadeh Motavallian Ehsan Zamani Saba Bouzari Farzam Rezaeyan Paridokht Karimian Mehdi Evazalipour
author_facet	Azadeh Motavallian Ehsan Zamani Saba Bouzari Farzam Rezaeyan Paridokht Karimian Mehdi Evazalipour
author_sort	Azadeh Motavallian
title	Anti-inflammatory effect of pregabalin on acetic acid-induced colitis in the rats
title_short	Anti-inflammatory effect of pregabalin on acetic acid-induced colitis in the rats
title_full	Anti-inflammatory effect of pregabalin on acetic acid-induced colitis in the rats
title_fullStr	Anti-inflammatory effect of pregabalin on acetic acid-induced colitis in the rats
title_full_unstemmed	Anti-inflammatory effect of pregabalin on acetic acid-induced colitis in the rats
title_sort	anti-inflammatory effect of pregabalin on acetic acid-induced colitis in the rats
publisher	Wolters Kluwer Medknow Publications
publishDate	2022
url	https://doaj.org/article/26c2739823164b90973ab9a126da7a76
work_keys_str_mv	AT azadehmotavallian antiinflammatoryeffectofpregabalinonaceticacidinducedcolitisintherats AT ehsanzamani antiinflammatoryeffectofpregabalinonaceticacidinducedcolitisintherats AT sababouzari antiinflammatoryeffectofpregabalinonaceticacidinducedcolitisintherats AT farzamrezaeyan antiinflammatoryeffectofpregabalinonaceticacidinducedcolitisintherats AT paridokhtkarimian antiinflammatoryeffectofpregabalinonaceticacidinducedcolitisintherats AT mehdievazalipour antiinflammatoryeffectofpregabalinonaceticacidinducedcolitisintherats
_version_	1718420059961950208

Anti-inflammatory effect of pregabalin on acetic acid-induced colitis in the rats

Ejemplares similares