Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis

Gip1 sequesters heterotrimeric G proteins in the cytosolic pool which regulates G protein-coupled receptor signalling for eukaryotic chemotaxis. Here the authors provide the crystal structure of Gip1's G protein-binding region and show that mutations in this region lead to G protein sequestrati...

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Autores principales:	Takero Miyagawa, Hiroyasu Koteishi, Yoichiro Kamimura, Yukihiro Miyanaga, Kohei Takeshita, Atsushi Nakagawa, Masahiro Ueda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26c4cb29ce9e49fc94c2bac5a504119a
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spelling	oai:doaj.org-article:26c4cb29ce9e49fc94c2bac5a504119a2021-12-02T17:31:44ZStructural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis10.1038/s41467-018-07035-x2041-1723https://doaj.org/article/26c4cb29ce9e49fc94c2bac5a504119a2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07035-xhttps://doaj.org/toc/2041-1723Gip1 sequesters heterotrimeric G proteins in the cytosolic pool which regulates G protein-coupled receptor signalling for eukaryotic chemotaxis. Here the authors provide the crystal structure of Gip1's G protein-binding region and show that mutations in this region lead to G protein sequestration and ultimately chemotaxis defects.Takero MiyagawaHiroyasu KoteishiYoichiro KamimuraYukihiro MiyanagaKohei TakeshitaAtsushi NakagawaMasahiro UedaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takero Miyagawa Hiroyasu Koteishi Yoichiro Kamimura Yukihiro Miyanaga Kohei Takeshita Atsushi Nakagawa Masahiro Ueda Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis
description	Gip1 sequesters heterotrimeric G proteins in the cytosolic pool which regulates G protein-coupled receptor signalling for eukaryotic chemotaxis. Here the authors provide the crystal structure of Gip1's G protein-binding region and show that mutations in this region lead to G protein sequestration and ultimately chemotaxis defects.
format	article
author	Takero Miyagawa Hiroyasu Koteishi Yoichiro Kamimura Yukihiro Miyanaga Kohei Takeshita Atsushi Nakagawa Masahiro Ueda
author_facet	Takero Miyagawa Hiroyasu Koteishi Yoichiro Kamimura Yukihiro Miyanaga Kohei Takeshita Atsushi Nakagawa Masahiro Ueda
author_sort	Takero Miyagawa
title	Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis
title_short	Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis
title_full	Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis
title_fullStr	Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis
title_full_unstemmed	Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis
title_sort	structural basis of gip1 for cytosolic sequestration of g protein in wide-range chemotaxis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/26c4cb29ce9e49fc94c2bac5a504119a
work_keys_str_mv	AT takeromiyagawa structuralbasisofgip1forcytosolicsequestrationofgproteininwiderangechemotaxis AT hiroyasukoteishi structuralbasisofgip1forcytosolicsequestrationofgproteininwiderangechemotaxis AT yoichirokamimura structuralbasisofgip1forcytosolicsequestrationofgproteininwiderangechemotaxis AT yukihiromiyanaga structuralbasisofgip1forcytosolicsequestrationofgproteininwiderangechemotaxis AT koheitakeshita structuralbasisofgip1forcytosolicsequestrationofgproteininwiderangechemotaxis AT atsushinakagawa structuralbasisofgip1forcytosolicsequestrationofgproteininwiderangechemotaxis AT masahiroueda structuralbasisofgip1forcytosolicsequestrationofgproteininwiderangechemotaxis
_version_	1718380477512941568

Structural basis of Gip1 for cytosolic sequestration of G protein in wide-range chemotaxis

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