Individual alpha peak frequency is slower in schizophrenia and related to deficits in visual perception and cognition

Abstract The brain at rest generates cycles of electrical activity that have been shown to be abnormal in people with schizophrenia. The alpha rhythm (~ 10 Hz) is the dominant resting state electrical cycle and each person has a propensity toward a particular frequency of oscillation for this rhythm...

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Autores principales:	Ian S. Ramsay, Peter Lynn, Brandon Schermitzler, Scott Sponheim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/26c96e711bea4a3781d348d5eddcacfb
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spelling	oai:doaj.org-article:26c96e711bea4a3781d348d5eddcacfb2021-12-02T17:41:18ZIndividual alpha peak frequency is slower in schizophrenia and related to deficits in visual perception and cognition10.1038/s41598-021-97303-62045-2322https://doaj.org/article/26c96e711bea4a3781d348d5eddcacfb2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97303-6https://doaj.org/toc/2045-2322Abstract The brain at rest generates cycles of electrical activity that have been shown to be abnormal in people with schizophrenia. The alpha rhythm (~ 10 Hz) is the dominant resting state electrical cycle and each person has a propensity toward a particular frequency of oscillation for this rhythm. This individual alpha peak frequency (IAPF) is hypothesized to be central to visual perceptual processes and may have downstream influences on cognitive functions such as attention, working memory, or problem solving. In the current study we sought to determine whether IAPF was slower in schizophrenia, and whether lower IAPF predicted deficits in visual perception and cognition that are often observed in schizophrenia. Eyes-closed resting state EEG activity, visual attention, and global cognitive functioning were assessed in individuals with schizophrenia (N = 104) and a group of healthy controls (N = 101). Compared to controls, the schizophrenia group showed slower IAPF and was associated with poorer discrimination of visual targets and nontargets on a computerized attention task, as well as impaired global cognition measured using neuropsychological tests across groups. Notably, disruptions in visual attention fully mediated the relationship between IAPF and global cognition across groups. The current findings demonstrate that slower alpha oscillatory cycling accounts for global cognitive deficits in schizophrenia by way of impairments in perceptual discrimination measured during a visual attention task.Ian S. RamsayPeter LynnBrandon SchermitzlerScott SponheimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ian S. Ramsay Peter Lynn Brandon Schermitzler Scott Sponheim Individual alpha peak frequency is slower in schizophrenia and related to deficits in visual perception and cognition
description	Abstract The brain at rest generates cycles of electrical activity that have been shown to be abnormal in people with schizophrenia. The alpha rhythm (~ 10 Hz) is the dominant resting state electrical cycle and each person has a propensity toward a particular frequency of oscillation for this rhythm. This individual alpha peak frequency (IAPF) is hypothesized to be central to visual perceptual processes and may have downstream influences on cognitive functions such as attention, working memory, or problem solving. In the current study we sought to determine whether IAPF was slower in schizophrenia, and whether lower IAPF predicted deficits in visual perception and cognition that are often observed in schizophrenia. Eyes-closed resting state EEG activity, visual attention, and global cognitive functioning were assessed in individuals with schizophrenia (N = 104) and a group of healthy controls (N = 101). Compared to controls, the schizophrenia group showed slower IAPF and was associated with poorer discrimination of visual targets and nontargets on a computerized attention task, as well as impaired global cognition measured using neuropsychological tests across groups. Notably, disruptions in visual attention fully mediated the relationship between IAPF and global cognition across groups. The current findings demonstrate that slower alpha oscillatory cycling accounts for global cognitive deficits in schizophrenia by way of impairments in perceptual discrimination measured during a visual attention task.
format	article
author	Ian S. Ramsay Peter Lynn Brandon Schermitzler Scott Sponheim
author_facet	Ian S. Ramsay Peter Lynn Brandon Schermitzler Scott Sponheim
author_sort	Ian S. Ramsay
title	Individual alpha peak frequency is slower in schizophrenia and related to deficits in visual perception and cognition
title_short	Individual alpha peak frequency is slower in schizophrenia and related to deficits in visual perception and cognition
title_full	Individual alpha peak frequency is slower in schizophrenia and related to deficits in visual perception and cognition
title_fullStr	Individual alpha peak frequency is slower in schizophrenia and related to deficits in visual perception and cognition
title_full_unstemmed	Individual alpha peak frequency is slower in schizophrenia and related to deficits in visual perception and cognition
title_sort	individual alpha peak frequency is slower in schizophrenia and related to deficits in visual perception and cognition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/26c96e711bea4a3781d348d5eddcacfb
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Individual alpha peak frequency is slower in schizophrenia and related to deficits in visual perception and cognition

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