Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis
Lung cancer is the second most frequently diagnosed cancer and the leading cause of cancer death worldwide, making its prevention an urgent issue. Meanwhile, the estimated prevalence of insomnia was as high as 30% globally. Research on the causal effect of insomnia on lung cancer incidence is still...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:26c9b49673f8453fb20c2ee7ba67ff5b2021-12-02T00:14:21ZGenetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis1664-802110.3389/fgene.2021.756908https://doaj.org/article/26c9b49673f8453fb20c2ee7ba67ff5b2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.756908/fullhttps://doaj.org/toc/1664-8021Lung cancer is the second most frequently diagnosed cancer and the leading cause of cancer death worldwide, making its prevention an urgent issue. Meanwhile, the estimated prevalence of insomnia was as high as 30% globally. Research on the causal effect of insomnia on lung cancer incidence is still lacking. In this study, we aimed to assess the causality between the genetic liability to insomnia and lung cancer. We performed a two-sample Mendelian randomization analysis (inverse variance weighted) to determine the causality between the genetic liability to insomnia and lung cancer. Subgroup analysis was conducted, which included lung adenocarcinoma and lung squamous cell carcinoma. In the sensitivity analysis, we conducted heterogeneity test, MR Egger, single SNP analysis, leave-one-out analysis, and MR PRESSO. There were causalities between the genetic susceptibility to insomnia and increased incidence of lung cancer [odds ratio (95% confidence interval), 1.35 (1.14–1.59); P, < 0.001], lung adenocarcinoma [odds ratio (95% confidence interval), 1.35 (1.07–1.70); P, 0.01], and lung squamous cell carcinoma [odds ratio (95% confidence interval), 1.35 (1.06–1.72), P, 0.02]. No violation of Mendelian randomization assumptions was observed in the sensitivity analysis. There was a causal relationship between the genetic susceptibility to insomnia and the lung cancer, which was also observed in lung adenocarcinoma and lung squamous cell carcinoma. The underlying mechanism remains unknown. Effective intervention and management for insomnia were recommended to improve the sleep quality and to prevent lung cancer. Moreover, regular screening for lung cancer may be beneficial for patients with insomnia.Jiayi ShenJiayi ShenJiayi ShenJiayi ShenHuaqiang ZhouHuaqiang ZhouHuaqiang ZhouJiaqing LiuJiaqing LiuJiaqing LiuYaxiong ZhangYaxiong ZhangYaxiong ZhangTing ZhouTing ZhouTing ZhouGang ChenGang ChenGang ChenWenfeng FangWenfeng FangWenfeng FangYunpeng YangYunpeng YangYunpeng YangYan HuangYan HuangYan HuangLi ZhangLi ZhangLi ZhangFrontiers Media S.A.articleinsomnialung cancermendelian randomization analysiscausalitypreventionGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
insomnia lung cancer mendelian randomization analysis causality prevention Genetics QH426-470 |
| spellingShingle |
insomnia lung cancer mendelian randomization analysis causality prevention Genetics QH426-470 Jiayi Shen Jiayi Shen Jiayi Shen Jiayi Shen Huaqiang Zhou Huaqiang Zhou Huaqiang Zhou Jiaqing Liu Jiaqing Liu Jiaqing Liu Yaxiong Zhang Yaxiong Zhang Yaxiong Zhang Ting Zhou Ting Zhou Ting Zhou Gang Chen Gang Chen Gang Chen Wenfeng Fang Wenfeng Fang Wenfeng Fang Yunpeng Yang Yunpeng Yang Yunpeng Yang Yan Huang Yan Huang Yan Huang Li Zhang Li Zhang Li Zhang Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis |
| description |
Lung cancer is the second most frequently diagnosed cancer and the leading cause of cancer death worldwide, making its prevention an urgent issue. Meanwhile, the estimated prevalence of insomnia was as high as 30% globally. Research on the causal effect of insomnia on lung cancer incidence is still lacking. In this study, we aimed to assess the causality between the genetic liability to insomnia and lung cancer. We performed a two-sample Mendelian randomization analysis (inverse variance weighted) to determine the causality between the genetic liability to insomnia and lung cancer. Subgroup analysis was conducted, which included lung adenocarcinoma and lung squamous cell carcinoma. In the sensitivity analysis, we conducted heterogeneity test, MR Egger, single SNP analysis, leave-one-out analysis, and MR PRESSO. There were causalities between the genetic susceptibility to insomnia and increased incidence of lung cancer [odds ratio (95% confidence interval), 1.35 (1.14–1.59); P, < 0.001], lung adenocarcinoma [odds ratio (95% confidence interval), 1.35 (1.07–1.70); P, 0.01], and lung squamous cell carcinoma [odds ratio (95% confidence interval), 1.35 (1.06–1.72), P, 0.02]. No violation of Mendelian randomization assumptions was observed in the sensitivity analysis. There was a causal relationship between the genetic susceptibility to insomnia and the lung cancer, which was also observed in lung adenocarcinoma and lung squamous cell carcinoma. The underlying mechanism remains unknown. Effective intervention and management for insomnia were recommended to improve the sleep quality and to prevent lung cancer. Moreover, regular screening for lung cancer may be beneficial for patients with insomnia. |
| format |
article |
| author |
Jiayi Shen Jiayi Shen Jiayi Shen Jiayi Shen Huaqiang Zhou Huaqiang Zhou Huaqiang Zhou Jiaqing Liu Jiaqing Liu Jiaqing Liu Yaxiong Zhang Yaxiong Zhang Yaxiong Zhang Ting Zhou Ting Zhou Ting Zhou Gang Chen Gang Chen Gang Chen Wenfeng Fang Wenfeng Fang Wenfeng Fang Yunpeng Yang Yunpeng Yang Yunpeng Yang Yan Huang Yan Huang Yan Huang Li Zhang Li Zhang Li Zhang |
| author_facet |
Jiayi Shen Jiayi Shen Jiayi Shen Jiayi Shen Huaqiang Zhou Huaqiang Zhou Huaqiang Zhou Jiaqing Liu Jiaqing Liu Jiaqing Liu Yaxiong Zhang Yaxiong Zhang Yaxiong Zhang Ting Zhou Ting Zhou Ting Zhou Gang Chen Gang Chen Gang Chen Wenfeng Fang Wenfeng Fang Wenfeng Fang Yunpeng Yang Yunpeng Yang Yunpeng Yang Yan Huang Yan Huang Yan Huang Li Zhang Li Zhang Li Zhang |
| author_sort |
Jiayi Shen |
| title |
Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis |
| title_short |
Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis |
| title_full |
Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis |
| title_fullStr |
Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis |
| title_full_unstemmed |
Genetic Liability to Insomnia and Lung Cancer Risk: A Mendelian Randomization Analysis |
| title_sort |
genetic liability to insomnia and lung cancer risk: a mendelian randomization analysis |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/26c9b49673f8453fb20c2ee7ba67ff5b |
| work_keys_str_mv |
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