USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy

USP24 has previously been reported to be involved in cancer progression. Here, the authors demonstrate that USP24 stabilizes p300 and β-TrCP to increase the levels of NF-κB and histone-3 acetylation, and decrease DNMT1 and IκB levels which promotes IL-6 expression in M2 macrophages and lung cancer c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yi-Chang Wang, Yu-Syuan Wu, Chia-Yang Hung, Shao-An Wang, Ming-Jer Young, Tsung-I Hsu, Jan-Jong Hung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26cc8ac4dab1440cb49c6ac5e82792df
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:26cc8ac4dab1440cb49c6ac5e82792df
record_format	dspace
spelling	oai:doaj.org-article:26cc8ac4dab1440cb49c6ac5e82792df2021-12-02T14:38:51ZUSP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy10.1038/s41467-018-06178-12041-1723https://doaj.org/article/26cc8ac4dab1440cb49c6ac5e82792df2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06178-1https://doaj.org/toc/2041-1723USP24 has previously been reported to be involved in cancer progression. Here, the authors demonstrate that USP24 stabilizes p300 and β-TrCP to increase the levels of NF-κB and histone-3 acetylation, and decrease DNMT1 and IκB levels which promotes IL-6 expression in M2 macrophages and lung cancer cells.Yi-Chang WangYu-Syuan WuChia-Yang HungShao-An WangMing-Jer YoungTsung-I HsuJan-Jong HungNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi-Chang Wang Yu-Syuan Wu Chia-Yang Hung Shao-An Wang Ming-Jer Young Tsung-I Hsu Jan-Jong Hung USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy
description	USP24 has previously been reported to be involved in cancer progression. Here, the authors demonstrate that USP24 stabilizes p300 and β-TrCP to increase the levels of NF-κB and histone-3 acetylation, and decrease DNMT1 and IκB levels which promotes IL-6 expression in M2 macrophages and lung cancer cells.
format	article
author	Yi-Chang Wang Yu-Syuan Wu Chia-Yang Hung Shao-An Wang Ming-Jer Young Tsung-I Hsu Jan-Jong Hung
author_facet	Yi-Chang Wang Yu-Syuan Wu Chia-Yang Hung Shao-An Wang Ming-Jer Young Tsung-I Hsu Jan-Jong Hung
author_sort	Yi-Chang Wang
title	USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy
title_short	USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy
title_full	USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy
title_fullStr	USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy
title_full_unstemmed	USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy
title_sort	usp24 induces il-6 in tumor-associated microenvironment by stabilizing p300 and β-trcp and promotes cancer malignancy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/26cc8ac4dab1440cb49c6ac5e82792df
work_keys_str_mv	AT yichangwang usp24inducesil6intumorassociatedmicroenvironmentbystabilizingp300andbtrcpandpromotescancermalignancy AT yusyuanwu usp24inducesil6intumorassociatedmicroenvironmentbystabilizingp300andbtrcpandpromotescancermalignancy AT chiayanghung usp24inducesil6intumorassociatedmicroenvironmentbystabilizingp300andbtrcpandpromotescancermalignancy AT shaoanwang usp24inducesil6intumorassociatedmicroenvironmentbystabilizingp300andbtrcpandpromotescancermalignancy AT mingjeryoung usp24inducesil6intumorassociatedmicroenvironmentbystabilizingp300andbtrcpandpromotescancermalignancy AT tsungihsu usp24inducesil6intumorassociatedmicroenvironmentbystabilizingp300andbtrcpandpromotescancermalignancy AT janjonghung usp24inducesil6intumorassociatedmicroenvironmentbystabilizingp300andbtrcpandpromotescancermalignancy
_version_	1718390819812016128

USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy

Ejemplares similares