Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives

Abstract 10-Alkylthiocolchicines have been obtained and characterized by spectroscopic methods and their biological activities as: cytotoxic, anti-inflammatory and analgesic activities have been tested. Cytotoxic activity against SKOV-3 ovarian cell line for 10-alkylthiocolchicine analogues was repo...

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Autores principales:	Joanna Kurek, Krzysztof Myszkowski, Irena Okulicz-Kozaryn, Agnieszka Kurant, Ewa Kamińska, Michał Szulc, Błażej Rubiś, Mariusz Kaczmarek, Przemysław Ł. Mikołajczak, Marek Murias
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/26cede43fda54840a3c5a6bd12d37121
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spelling	oai:doaj.org-article:26cede43fda54840a3c5a6bd12d371212021-12-02T13:40:51ZCytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives10.1038/s41598-021-88260-12045-2322https://doaj.org/article/26cede43fda54840a3c5a6bd12d371212021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88260-1https://doaj.org/toc/2045-2322Abstract 10-Alkylthiocolchicines have been obtained and characterized by spectroscopic methods and their biological activities as: cytotoxic, anti-inflammatory and analgesic activities have been tested. Cytotoxic activity against SKOV-3 ovarian cell line for 10-alkylthiocolchicine analogues was reported and tested compounds showed to be more active than commonly used doxorubicin. Some of tested C-10 alkylthiolated colchicines have been found to exhibit cytotoxicity at levels comparable to that of the natural product—colchicine. 10-Methylthiocolchicine has IC50 = 8 nM and 10-ethylthiocolchicine has IC50 = 47 nM in comparison to colchicine IC50 = 37 nM. Moreover for 10-alkylthioderivatives apoptosis test, cyclin B1 and cell cycle tests were performed. 10-n-Butylthiocolchicine was tested for anti-inflammatory and analgesic activities it showed to produce analgesic rather than anti-inflammatory effect.Joanna KurekKrzysztof MyszkowskiIrena Okulicz-KozarynAgnieszka KurantEwa KamińskaMichał SzulcBłażej RubiśMariusz KaczmarekPrzemysław Ł. MikołajczakMarek MuriasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joanna Kurek Krzysztof Myszkowski Irena Okulicz-Kozaryn Agnieszka Kurant Ewa Kamińska Michał Szulc Błażej Rubiś Mariusz Kaczmarek Przemysław Ł. Mikołajczak Marek Murias Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives
description	Abstract 10-Alkylthiocolchicines have been obtained and characterized by spectroscopic methods and their biological activities as: cytotoxic, anti-inflammatory and analgesic activities have been tested. Cytotoxic activity against SKOV-3 ovarian cell line for 10-alkylthiocolchicine analogues was reported and tested compounds showed to be more active than commonly used doxorubicin. Some of tested C-10 alkylthiolated colchicines have been found to exhibit cytotoxicity at levels comparable to that of the natural product—colchicine. 10-Methylthiocolchicine has IC50 = 8 nM and 10-ethylthiocolchicine has IC50 = 47 nM in comparison to colchicine IC50 = 37 nM. Moreover for 10-alkylthioderivatives apoptosis test, cyclin B1 and cell cycle tests were performed. 10-n-Butylthiocolchicine was tested for anti-inflammatory and analgesic activities it showed to produce analgesic rather than anti-inflammatory effect.
format	article
author	Joanna Kurek Krzysztof Myszkowski Irena Okulicz-Kozaryn Agnieszka Kurant Ewa Kamińska Michał Szulc Błażej Rubiś Mariusz Kaczmarek Przemysław Ł. Mikołajczak Marek Murias
author_facet	Joanna Kurek Krzysztof Myszkowski Irena Okulicz-Kozaryn Agnieszka Kurant Ewa Kamińska Michał Szulc Błażej Rubiś Mariusz Kaczmarek Przemysław Ł. Mikołajczak Marek Murias
author_sort	Joanna Kurek
title	Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives
title_short	Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives
title_full	Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives
title_fullStr	Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives
title_full_unstemmed	Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives
title_sort	cytotoxic, analgesic and anti-inflammatory activity of colchicine and its c-10 sulfur containing derivatives
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/26cede43fda54840a3c5a6bd12d37121
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Cytotoxic, analgesic and anti-inflammatory activity of colchicine and its C-10 sulfur containing derivatives

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