In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness

Neurons of the locus coeruleus (LC) are implicated in attention and arousal. Here the authors use CRISPR/Cas9 to disrupt dopamine beta hydroxylase in LC neurons and see this reduces LC-evoked sleep-to-wake transitions and wake length.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hiroshi Yamaguchi, F. Woodward Hopf, Shi-Bin Li, Luis de Lecea
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26d3ded6f2ac42a3a93af43e8748351e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:26d3ded6f2ac42a3a93af43e8748351e
record_format	dspace
spelling	oai:doaj.org-article:26d3ded6f2ac42a3a93af43e8748351e2021-12-02T14:38:50ZIn vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness10.1038/s41467-018-07566-32041-1723https://doaj.org/article/26d3ded6f2ac42a3a93af43e8748351e2018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07566-3https://doaj.org/toc/2041-1723Neurons of the locus coeruleus (LC) are implicated in attention and arousal. Here the authors use CRISPR/Cas9 to disrupt dopamine beta hydroxylase in LC neurons and see this reduces LC-evoked sleep-to-wake transitions and wake length.Hiroshi YamaguchiF. Woodward HopfShi-Bin LiLuis de LeceaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hiroshi Yamaguchi F. Woodward Hopf Shi-Bin Li Luis de Lecea In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness
description	Neurons of the locus coeruleus (LC) are implicated in attention and arousal. Here the authors use CRISPR/Cas9 to disrupt dopamine beta hydroxylase in LC neurons and see this reduces LC-evoked sleep-to-wake transitions and wake length.
format	article
author	Hiroshi Yamaguchi F. Woodward Hopf Shi-Bin Li Luis de Lecea
author_facet	Hiroshi Yamaguchi F. Woodward Hopf Shi-Bin Li Luis de Lecea
author_sort	Hiroshi Yamaguchi
title	In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness
title_short	In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness
title_full	In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness
title_fullStr	In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness
title_full_unstemmed	In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness
title_sort	in vivo cell type-specific crispr knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/26d3ded6f2ac42a3a93af43e8748351e
work_keys_str_mv	AT hiroshiyamaguchi invivocelltypespecificcrisprknockdownofdopaminebetahydroxylasereduceslocuscoeruleusevokedwakefulness AT fwoodwardhopf invivocelltypespecificcrisprknockdownofdopaminebetahydroxylasereduceslocuscoeruleusevokedwakefulness AT shibinli invivocelltypespecificcrisprknockdownofdopaminebetahydroxylasereduceslocuscoeruleusevokedwakefulness AT luisdelecea invivocelltypespecificcrisprknockdownofdopaminebetahydroxylasereduceslocuscoeruleusevokedwakefulness
_version_	1718390819991322624

In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness

Ejemplares similares