ISG15 deficiency and increased viral resistance in humans but not mice
ISG15 is a ubiquitin-like protein which has important immune-related functions in mice and humans. Here the authors demonstrate that, unlike in mice, human ISG15 stabilizes UPS18 and that ISG15-deficient human cells are more resistant to viral infection.
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Nature Portfolio
2016
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oai:doaj.org-article:26d5278e9a6e4fe9b0df50d459031fb12021-12-02T17:31:50ZISG15 deficiency and increased viral resistance in humans but not mice10.1038/ncomms114962041-1723https://doaj.org/article/26d5278e9a6e4fe9b0df50d459031fb12016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11496https://doaj.org/toc/2041-1723ISG15 is a ubiquitin-like protein which has important immune-related functions in mice and humans. Here the authors demonstrate that, unlike in mice, human ISG15 stabilizes UPS18 and that ISG15-deficient human cells are more resistant to viral infection.Scott D. SpeerZhi LiSofija ButaBéatrice Payelle-BrogardLi QianFrederic VigantErminia RubinoThomas J. GardnerTim WedekingMark HermannJames DuehrOzden SanalIlhan TezcanNahal MansouriPayam TabarsiDavood MansouriVéronique Francois-NewtonCoralie F. DaussyMarisela R. RodriguezDeborah J. LenschowAlexander N. FreibergDomenico TortorellaJacob PiehlerBenhur LeeAdolfo García-SastreSandra PellegriniDusan BogunovicNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016) |
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| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Scott D. Speer Zhi Li Sofija Buta Béatrice Payelle-Brogard Li Qian Frederic Vigant Erminia Rubino Thomas J. Gardner Tim Wedeking Mark Hermann James Duehr Ozden Sanal Ilhan Tezcan Nahal Mansouri Payam Tabarsi Davood Mansouri Véronique Francois-Newton Coralie F. Daussy Marisela R. Rodriguez Deborah J. Lenschow Alexander N. Freiberg Domenico Tortorella Jacob Piehler Benhur Lee Adolfo García-Sastre Sandra Pellegrini Dusan Bogunovic ISG15 deficiency and increased viral resistance in humans but not mice |
| description |
ISG15 is a ubiquitin-like protein which has important immune-related functions in mice and humans. Here the authors demonstrate that, unlike in mice, human ISG15 stabilizes UPS18 and that ISG15-deficient human cells are more resistant to viral infection. |
| format |
article |
| author |
Scott D. Speer Zhi Li Sofija Buta Béatrice Payelle-Brogard Li Qian Frederic Vigant Erminia Rubino Thomas J. Gardner Tim Wedeking Mark Hermann James Duehr Ozden Sanal Ilhan Tezcan Nahal Mansouri Payam Tabarsi Davood Mansouri Véronique Francois-Newton Coralie F. Daussy Marisela R. Rodriguez Deborah J. Lenschow Alexander N. Freiberg Domenico Tortorella Jacob Piehler Benhur Lee Adolfo García-Sastre Sandra Pellegrini Dusan Bogunovic |
| author_facet |
Scott D. Speer Zhi Li Sofija Buta Béatrice Payelle-Brogard Li Qian Frederic Vigant Erminia Rubino Thomas J. Gardner Tim Wedeking Mark Hermann James Duehr Ozden Sanal Ilhan Tezcan Nahal Mansouri Payam Tabarsi Davood Mansouri Véronique Francois-Newton Coralie F. Daussy Marisela R. Rodriguez Deborah J. Lenschow Alexander N. Freiberg Domenico Tortorella Jacob Piehler Benhur Lee Adolfo García-Sastre Sandra Pellegrini Dusan Bogunovic |
| author_sort |
Scott D. Speer |
| title |
ISG15 deficiency and increased viral resistance in humans but not mice |
| title_short |
ISG15 deficiency and increased viral resistance in humans but not mice |
| title_full |
ISG15 deficiency and increased viral resistance in humans but not mice |
| title_fullStr |
ISG15 deficiency and increased viral resistance in humans but not mice |
| title_full_unstemmed |
ISG15 deficiency and increased viral resistance in humans but not mice |
| title_sort |
isg15 deficiency and increased viral resistance in humans but not mice |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/26d5278e9a6e4fe9b0df50d459031fb1 |
| work_keys_str_mv |
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