Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis

Abstract Metabolic dysfunction in chondrocytes drives the pro-catabolic phenotype associated with osteoarthritic cartilage. In this study, substitution of galactose for glucose in culture media was used to promote a renewed dependence on mitochondrial respiration and oxidative phosphorylation. Galac...

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Autores principales: Yoshifumi Ohashi, Nobunori Takahashi, Kenya Terabe, Saho Tsuchiya, Toshihisa Kojima, Cheryl B. Knudson, Warren Knudson, Shiro Imagama
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/26d7bfdef80d45b389fbf4f5a7d05ae5
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