Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that se...
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Nature Portfolio
2019
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oai:doaj.org-article:26d9a5825ab940e5a49b115dd12d8fe32021-12-02T17:31:37ZSynergized regulation of NK cell education by NKG2A and specific Ly49 family members10.1038/s41467-019-13032-52041-1723https://doaj.org/article/26d9a5825ab940e5a49b115dd12d8fe32019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13032-5https://doaj.org/toc/2041-1723MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that self-MHCI specific Ly49 members and NKG2A synergize to regulate NK education.Xiaoqian ZhangJin FengShasha ChenHaoyan YangZhongjun DongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
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Science Q Xiaoqian Zhang Jin Feng Shasha Chen Haoyan Yang Zhongjun Dong Synergized regulation of NK cell education by NKG2A and specific Ly49 family members |
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MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that self-MHCI specific Ly49 members and NKG2A synergize to regulate NK education. |
format |
article |
author |
Xiaoqian Zhang Jin Feng Shasha Chen Haoyan Yang Zhongjun Dong |
author_facet |
Xiaoqian Zhang Jin Feng Shasha Chen Haoyan Yang Zhongjun Dong |
author_sort |
Xiaoqian Zhang |
title |
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members |
title_short |
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members |
title_full |
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members |
title_fullStr |
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members |
title_full_unstemmed |
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members |
title_sort |
synergized regulation of nk cell education by nkg2a and specific ly49 family members |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/26d9a5825ab940e5a49b115dd12d8fe3 |
work_keys_str_mv |
AT xiaoqianzhang synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers AT jinfeng synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers AT shashachen synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers AT haoyanyang synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers AT zhongjundong synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers |
_version_ |
1718380540197863424 |