Synergized regulation of NK cell education by NKG2A and specific Ly49 family members

MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that se...

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Autores principales: Xiaoqian Zhang, Jin Feng, Shasha Chen, Haoyan Yang, Zhongjun Dong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/26d9a5825ab940e5a49b115dd12d8fe3
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spelling oai:doaj.org-article:26d9a5825ab940e5a49b115dd12d8fe32021-12-02T17:31:37ZSynergized regulation of NK cell education by NKG2A and specific Ly49 family members10.1038/s41467-019-13032-52041-1723https://doaj.org/article/26d9a5825ab940e5a49b115dd12d8fe32019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13032-5https://doaj.org/toc/2041-1723MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that self-MHCI specific Ly49 members and NKG2A synergize to regulate NK education.Xiaoqian ZhangJin FengShasha ChenHaoyan YangZhongjun DongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaoqian Zhang
Jin Feng
Shasha Chen
Haoyan Yang
Zhongjun Dong
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
description MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that self-MHCI specific Ly49 members and NKG2A synergize to regulate NK education.
format article
author Xiaoqian Zhang
Jin Feng
Shasha Chen
Haoyan Yang
Zhongjun Dong
author_facet Xiaoqian Zhang
Jin Feng
Shasha Chen
Haoyan Yang
Zhongjun Dong
author_sort Xiaoqian Zhang
title Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
title_short Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
title_full Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
title_fullStr Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
title_full_unstemmed Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
title_sort synergized regulation of nk cell education by nkg2a and specific ly49 family members
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/26d9a5825ab940e5a49b115dd12d8fe3
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AT jinfeng synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers
AT shashachen synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers
AT haoyanyang synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers
AT zhongjundong synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers
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