Synergized regulation of NK cell education by NKG2A and specific Ly49 family members

MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that se...

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Main Authors:	Xiaoqian Zhang, Jin Feng, Shasha Chen, Haoyan Yang, Zhongjun Dong
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/26d9a5825ab940e5a49b115dd12d8fe3
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id	oai:doaj.org-article:26d9a5825ab940e5a49b115dd12d8fe3
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spelling	oai:doaj.org-article:26d9a5825ab940e5a49b115dd12d8fe32021-12-02T17:31:37ZSynergized regulation of NK cell education by NKG2A and specific Ly49 family members10.1038/s41467-019-13032-52041-1723https://doaj.org/article/26d9a5825ab940e5a49b115dd12d8fe32019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13032-5https://doaj.org/toc/2041-1723MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that self-MHCI specific Ly49 members and NKG2A synergize to regulate NK education.Xiaoqian ZhangJin FengShasha ChenHaoyan YangZhongjun DongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaoqian Zhang Jin Feng Shasha Chen Haoyan Yang Zhongjun Dong Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
description	MHC-I-induced signalling of various natural killer (NK) inhibitory receptors is critical for regulation NK cell education, but clear genetic evidence is still lacking. Here the authors generate multiple lines of mice differentially deficient in Ly49 family and/or NKG2A NK receptors, and find that self-MHCI specific Ly49 members and NKG2A synergize to regulate NK education.
format	article
author	Xiaoqian Zhang Jin Feng Shasha Chen Haoyan Yang Zhongjun Dong
author_facet	Xiaoqian Zhang Jin Feng Shasha Chen Haoyan Yang Zhongjun Dong
author_sort	Xiaoqian Zhang
title	Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
title_short	Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
title_full	Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
title_fullStr	Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
title_full_unstemmed	Synergized regulation of NK cell education by NKG2A and specific Ly49 family members
title_sort	synergized regulation of nk cell education by nkg2a and specific ly49 family members
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/26d9a5825ab940e5a49b115dd12d8fe3
work_keys_str_mv	AT xiaoqianzhang synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers AT jinfeng synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers AT shashachen synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers AT haoyanyang synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers AT zhongjundong synergizedregulationofnkcelleducationbynkg2aandspecificly49familymembers
_version_	1718380540197863424

Synergized regulation of NK cell education by NKG2A and specific Ly49 family members

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