Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist

Adoptive cell transfer (ACT) of T cells for tumor treatment often requires IL-2 administration. Here, the authors show that a modified IL-2 cytokine (NKTR-214) can outperform IL-2 in a melanoma mouse model.

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Autores principales:	Giulia Parisi, Justin D. Saco, Felix B. Salazar, Jennifer Tsoi, Paige Krystofinski, Cristina Puig-Saus, Ruixue Zhang, Jing Zhou, Gardenia C. Cheung-Lau, Alejandro J. Garcia, Catherine S. Grasso, Richard Tavaré, Siwen Hu-Lieskovan, Sean Mackay, Jonathan Zalevsky, Chantale Bernatchez, Adi Diab, Anna M. Wu, Begoña Comin-Anduix, Deborah Charych, Antoni Ribas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26da1a14c88d4cdbbb1ebbe52eeb9731
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spelling	oai:doaj.org-article:26da1a14c88d4cdbbb1ebbe52eeb97312021-12-02T15:39:27ZPersistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist10.1038/s41467-019-12901-32041-1723https://doaj.org/article/26da1a14c88d4cdbbb1ebbe52eeb97312020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12901-3https://doaj.org/toc/2041-1723Adoptive cell transfer (ACT) of T cells for tumor treatment often requires IL-2 administration. Here, the authors show that a modified IL-2 cytokine (NKTR-214) can outperform IL-2 in a melanoma mouse model.Giulia ParisiJustin D. SacoFelix B. SalazarJennifer TsoiPaige KrystofinskiCristina Puig-SausRuixue ZhangJing ZhouGardenia C. Cheung-LauAlejandro J. GarciaCatherine S. GrassoRichard TavaréSiwen Hu-LieskovanSean MackayJonathan ZalevskyChantale BernatchezAdi DiabAnna M. WuBegoña Comin-AnduixDeborah CharychAntoni RibasNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giulia Parisi Justin D. Saco Felix B. Salazar Jennifer Tsoi Paige Krystofinski Cristina Puig-Saus Ruixue Zhang Jing Zhou Gardenia C. Cheung-Lau Alejandro J. Garcia Catherine S. Grasso Richard Tavaré Siwen Hu-Lieskovan Sean Mackay Jonathan Zalevsky Chantale Bernatchez Adi Diab Anna M. Wu Begoña Comin-Anduix Deborah Charych Antoni Ribas Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist
description	Adoptive cell transfer (ACT) of T cells for tumor treatment often requires IL-2 administration. Here, the authors show that a modified IL-2 cytokine (NKTR-214) can outperform IL-2 in a melanoma mouse model.
format	article
author	Giulia Parisi Justin D. Saco Felix B. Salazar Jennifer Tsoi Paige Krystofinski Cristina Puig-Saus Ruixue Zhang Jing Zhou Gardenia C. Cheung-Lau Alejandro J. Garcia Catherine S. Grasso Richard Tavaré Siwen Hu-Lieskovan Sean Mackay Jonathan Zalevsky Chantale Bernatchez Adi Diab Anna M. Wu Begoña Comin-Anduix Deborah Charych Antoni Ribas
author_facet	Giulia Parisi Justin D. Saco Felix B. Salazar Jennifer Tsoi Paige Krystofinski Cristina Puig-Saus Ruixue Zhang Jing Zhou Gardenia C. Cheung-Lau Alejandro J. Garcia Catherine S. Grasso Richard Tavaré Siwen Hu-Lieskovan Sean Mackay Jonathan Zalevsky Chantale Bernatchez Adi Diab Anna M. Wu Begoña Comin-Anduix Deborah Charych Antoni Ribas
author_sort	Giulia Parisi
title	Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist
title_short	Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist
title_full	Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist
title_fullStr	Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist
title_full_unstemmed	Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist
title_sort	persistence of adoptively transferred t cells with a kinetically engineered il-2 receptor agonist
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/26da1a14c88d4cdbbb1ebbe52eeb9731
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Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist

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