ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES

Abstract. Taking into account close localization of genes encoding HSP70-2 and TNFα and mutual influence of their products upon development of septic process, we investigated allelic polymorphism in the coding region of HSP70-2 gene at position 1267, and a promoter polymorphism of TNFα gene (–308 po...

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Autores principales:	A. V. Shevchenko, O. V. Golovanova, V. I. Konenkov, E. I. Streltsova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	tnfα hsp70-2 surgical sepsis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/26da536dd5c84680bcfa65d9cf2991ec
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spelling	oai:doaj.org-article:26da536dd5c84680bcfa65d9cf2991ec2021-11-18T08:03:39ZASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES1563-06252313-741X10.15789/1563-0625-2007-4-5-429-434https://doaj.org/article/26da536dd5c84680bcfa65d9cf2991ec2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/199https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Taking into account close localization of genes encoding HSP70-2 and TNFα and mutual influence of their products upon development of septic process, we investigated allelic polymorphism in the coding region of HSP70-2 gene at position 1267, and a promoter polymorphism of TNFα gene (–308 position) in sixty-one patients with surgical sepsis, as compared with 100 healthy donors, assuming that certain genomic variants can be associated with susceptibility for sepsis and/or fatal outcomes in severe sepsis. Significant differences in frequencies of HSP70-2 gene alleles have been found in the group with sepsis against healthy controls. Prevalence of HSP70-2*B/B allele is increased in the group of patients with sepsis, and a predisposal for sepsis development is shown for carriers of the given genotype. When analyzing carriers of combined HSP70-2/TNFα allelic variants among dead patients vs survivors, we have revealed specific combinations that are detected solely among non-survived patients, i.e., HSP70-2 A/TNFα AA, or only among survivors (HSP70-2BB /TNFα AA и HSP70-2 BB/TNFα AG). The results obtained allow us to suggest about certain genetic factors that may sufficiently influence intensity of inflammation in sepsis and, hence, upon clinical manifestations and outcomes of the disease.A. V. ShevchenkoO. V. GolovanovaV. I. KonenkovE. I. StreltsovaSPb RAACIarticletnfαhsp70-2surgical sepsisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 4-5, Pp 429-434 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	tnfα hsp70-2 surgical sepsis Immunologic diseases. Allergy RC581-607
spellingShingle	tnfα hsp70-2 surgical sepsis Immunologic diseases. Allergy RC581-607 A. V. Shevchenko O. V. Golovanova V. I. Konenkov E. I. Streltsova ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES
description	Abstract. Taking into account close localization of genes encoding HSP70-2 and TNFα and mutual influence of their products upon development of septic process, we investigated allelic polymorphism in the coding region of HSP70-2 gene at position 1267, and a promoter polymorphism of TNFα gene (–308 position) in sixty-one patients with surgical sepsis, as compared with 100 healthy donors, assuming that certain genomic variants can be associated with susceptibility for sepsis and/or fatal outcomes in severe sepsis. Significant differences in frequencies of HSP70-2 gene alleles have been found in the group with sepsis against healthy controls. Prevalence of HSP70-2*B/B allele is increased in the group of patients with sepsis, and a predisposal for sepsis development is shown for carriers of the given genotype. When analyzing carriers of combined HSP70-2/TNFα allelic variants among dead patients vs survivors, we have revealed specific combinations that are detected solely among non-survived patients, i.e., HSP70-2 A/TNFα AA, or only among survivors (HSP70-2BB /TNFα AA и HSP70-2 BB/TNFα AG). The results obtained allow us to suggest about certain genetic factors that may sufficiently influence intensity of inflammation in sepsis and, hence, upon clinical manifestations and outcomes of the disease.
format	article
author	A. V. Shevchenko O. V. Golovanova V. I. Konenkov E. I. Streltsova
author_facet	A. V. Shevchenko O. V. Golovanova V. I. Konenkov E. I. Streltsova
author_sort	A. V. Shevchenko
title	ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES
title_short	ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES
title_full	ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES
title_fullStr	ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES
title_full_unstemmed	ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES
title_sort	association of lethal outcomes in surgical sepsis with allelic variants of tnf α and heat shock protein (hsp70-2) genes
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/26da536dd5c84680bcfa65d9cf2991ec
work_keys_str_mv	AT avshevchenko associationoflethaloutcomesinsurgicalsepsiswithallelicvariantsoftnfaandheatshockproteinhsp702genes AT ovgolovanova associationoflethaloutcomesinsurgicalsepsiswithallelicvariantsoftnfaandheatshockproteinhsp702genes AT vikonenkov associationoflethaloutcomesinsurgicalsepsiswithallelicvariantsoftnfaandheatshockproteinhsp702genes AT eistreltsova associationoflethaloutcomesinsurgicalsepsiswithallelicvariantsoftnfaandheatshockproteinhsp702genes
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ASSOCIATION OF LETHAL OUTCOMES IN SURGICAL SEPSIS WITH ALLELIC VARIANTS OF TNF Α AND HEAT SHOCK PROTEIN (HSP70-2) GENES

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