Diffusion Kurtosis Imaging of Microstructural Alterations in the Brains of Paediatric Patients with Congenital Sensorineural Hearing Loss

Abstract Our aim was to assess microstructural alterations in the cerebrums of paediatric patients with congenital sensorineural hearing loss (SNHL) using diffusion kurtosis imaging (DKI). Seventy-two paediatric SNHL patients and 38 age-matched healthy volunteers were examined via DKI using a 3.0 T...

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Autores principales:	Wenbin Zheng, Chunxiao Wu, Lexing Huang, Renhua Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/26dd7f76eb724a9e95191177e22295f0
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spelling	oai:doaj.org-article:26dd7f76eb724a9e95191177e22295f02021-12-02T16:06:01ZDiffusion Kurtosis Imaging of Microstructural Alterations in the Brains of Paediatric Patients with Congenital Sensorineural Hearing Loss10.1038/s41598-017-01263-92045-2322https://doaj.org/article/26dd7f76eb724a9e95191177e22295f02017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01263-9https://doaj.org/toc/2045-2322Abstract Our aim was to assess microstructural alterations in the cerebrums of paediatric patients with congenital sensorineural hearing loss (SNHL) using diffusion kurtosis imaging (DKI). Seventy-two paediatric SNHL patients and 38 age-matched healthy volunteers were examined via DKI using a 3.0 T magnetic resonance (MR) imager. Fractional anisotropy (FA) and mean kurtosis (MK) values were computed for 12 cerebral regions in both the controls and the SNHL patients. Compared with patients below age 3, patients in the older age group were found to have more significant differences in MK than in FA, and these appeared in more major areas of the brain. In contrast, in 1- to 3-year-old children, a few major brain areas exhibited differences in FA, but none exhibited appreciable differences in MK. There were significant decreases in the FA or MK values (P < 0.05, all) in more areas of the brain in patients with lesions than in patients with normal-appearing brains. DKI offers comprehensive measurements for quantitative evaluation of age-related microstructural changes in both white and grey matter in SNHL patients. DKI scans of children with SNHL exhibiting significant decreases in MK might play an important role in evaluating the severity of developmental delay.Wenbin ZhengChunxiao WuLexing HuangRenhua WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wenbin Zheng Chunxiao Wu Lexing Huang Renhua Wu Diffusion Kurtosis Imaging of Microstructural Alterations in the Brains of Paediatric Patients with Congenital Sensorineural Hearing Loss
description	Abstract Our aim was to assess microstructural alterations in the cerebrums of paediatric patients with congenital sensorineural hearing loss (SNHL) using diffusion kurtosis imaging (DKI). Seventy-two paediatric SNHL patients and 38 age-matched healthy volunteers were examined via DKI using a 3.0 T magnetic resonance (MR) imager. Fractional anisotropy (FA) and mean kurtosis (MK) values were computed for 12 cerebral regions in both the controls and the SNHL patients. Compared with patients below age 3, patients in the older age group were found to have more significant differences in MK than in FA, and these appeared in more major areas of the brain. In contrast, in 1- to 3-year-old children, a few major brain areas exhibited differences in FA, but none exhibited appreciable differences in MK. There were significant decreases in the FA or MK values (P < 0.05, all) in more areas of the brain in patients with lesions than in patients with normal-appearing brains. DKI offers comprehensive measurements for quantitative evaluation of age-related microstructural changes in both white and grey matter in SNHL patients. DKI scans of children with SNHL exhibiting significant decreases in MK might play an important role in evaluating the severity of developmental delay.
format	article
author	Wenbin Zheng Chunxiao Wu Lexing Huang Renhua Wu
author_facet	Wenbin Zheng Chunxiao Wu Lexing Huang Renhua Wu
author_sort	Wenbin Zheng
title	Diffusion Kurtosis Imaging of Microstructural Alterations in the Brains of Paediatric Patients with Congenital Sensorineural Hearing Loss
title_short	Diffusion Kurtosis Imaging of Microstructural Alterations in the Brains of Paediatric Patients with Congenital Sensorineural Hearing Loss
title_full	Diffusion Kurtosis Imaging of Microstructural Alterations in the Brains of Paediatric Patients with Congenital Sensorineural Hearing Loss
title_fullStr	Diffusion Kurtosis Imaging of Microstructural Alterations in the Brains of Paediatric Patients with Congenital Sensorineural Hearing Loss
title_full_unstemmed	Diffusion Kurtosis Imaging of Microstructural Alterations in the Brains of Paediatric Patients with Congenital Sensorineural Hearing Loss
title_sort	diffusion kurtosis imaging of microstructural alterations in the brains of paediatric patients with congenital sensorineural hearing loss
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/26dd7f76eb724a9e95191177e22295f0
work_keys_str_mv	AT wenbinzheng diffusionkurtosisimagingofmicrostructuralalterationsinthebrainsofpaediatricpatientswithcongenitalsensorineuralhearingloss AT chunxiaowu diffusionkurtosisimagingofmicrostructuralalterationsinthebrainsofpaediatricpatientswithcongenitalsensorineuralhearingloss AT lexinghuang diffusionkurtosisimagingofmicrostructuralalterationsinthebrainsofpaediatricpatientswithcongenitalsensorineuralhearingloss AT renhuawu diffusionkurtosisimagingofmicrostructuralalterationsinthebrainsofpaediatricpatientswithcongenitalsensorineuralhearingloss
_version_	1718385136431529984

Diffusion Kurtosis Imaging of Microstructural Alterations in the Brains of Paediatric Patients with Congenital Sensorineural Hearing Loss

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