New insights into the pathological development of dyslipidemia in patients with hypothyroidism

According to the previous reports, hypothyroidism has been shown to be strongly correlated with increased circulating concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). Notably, thyroid hormones are confirmed to modulate the production, cleara...

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Autores principales:	Xin Su, Xiang Chen, Hua Peng, Jingjin Song, Bin Wang, Xijie Wu
Formato:	article
Lenguaje:	EN
Publicado:	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2021
Materias:	Dyslipidemia hypothyroidism angiopoietin-like protein fibroblast growth factor PCSK9 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/26de6087423e4ea3aea214d0ec744e8e
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spelling	oai:doaj.org-article:26de6087423e4ea3aea214d0ec744e8e2021-11-16T17:17:55ZNew insights into the pathological development of dyslipidemia in patients with hypothyroidism10.17305/bjbms.2021.66061512-86011840-4812https://doaj.org/article/26de6087423e4ea3aea214d0ec744e8e2021-11-01T00:00:00Zhttps://www.bjbms.org/ojs/index.php/bjbms/article/view/6606https://doaj.org/toc/1512-8601https://doaj.org/toc/1840-4812 According to the previous reports, hypothyroidism has been shown to be strongly correlated with increased circulating concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). Notably, thyroid hormones are confirmed to modulate the production, clearance, and transformation process of cholesterol within circulation of mammals. Moreover, emerging evidence suggests that the thyroid-stimulating hormone could also participate in modulating serum lipid metabolism independently of thyroid hormones, which further induces the pathological development of dyslipidemia. However, the underlying mechanism is still not fully elucidated. Recently, several research studies have demonstrated that the pathogenic progression of hypothyroidism-related dyslipidemia might be correlated with the decreased serum concentrations of thyroid hormones and the increased serum concentrations of thyroid-stimulating hormones. Thus, this indicates that hypothyroidism could induce dyslipidemia and its related cardio-metabolic disorder diseases. In addition, several newly identified modulatory biomarkers, such as proprotein convertase subtilisin/kexin type 9 (PCSK9), angiopoietin-like protein (ANGPTLs), and fibroblast growth factors (FGFs), might play an important role in the regulation of dyslipidemia induced by hypothyroidism. Furthermore, under the status of hypothyroidism, significantly dysfunctional HDL particles could also be observed. In the current review, we summarized the recent knowledge of the relationship between the development of hypothyroidism with dyslipidemia. We also discussed the updated understanding of the mechanisms whereby hypothyroidism induces the risk and the development of dyslipidemia and cardio-metabolic diseases. Xin SuXiang ChenHua PengJingjin SongBin WangXijie WuAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaarticleDyslipidemiahypothyroidismangiopoietin-like proteinfibroblast growth factorPCSK9Medicine (General)R5-920ENBosnian Journal of Basic Medical Sciences (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dyslipidemia hypothyroidism angiopoietin-like protein fibroblast growth factor PCSK9 Medicine (General) R5-920
spellingShingle	Dyslipidemia hypothyroidism angiopoietin-like protein fibroblast growth factor PCSK9 Medicine (General) R5-920 Xin Su Xiang Chen Hua Peng Jingjin Song Bin Wang Xijie Wu New insights into the pathological development of dyslipidemia in patients with hypothyroidism
description	According to the previous reports, hypothyroidism has been shown to be strongly correlated with increased circulating concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). Notably, thyroid hormones are confirmed to modulate the production, clearance, and transformation process of cholesterol within circulation of mammals. Moreover, emerging evidence suggests that the thyroid-stimulating hormone could also participate in modulating serum lipid metabolism independently of thyroid hormones, which further induces the pathological development of dyslipidemia. However, the underlying mechanism is still not fully elucidated. Recently, several research studies have demonstrated that the pathogenic progression of hypothyroidism-related dyslipidemia might be correlated with the decreased serum concentrations of thyroid hormones and the increased serum concentrations of thyroid-stimulating hormones. Thus, this indicates that hypothyroidism could induce dyslipidemia and its related cardio-metabolic disorder diseases. In addition, several newly identified modulatory biomarkers, such as proprotein convertase subtilisin/kexin type 9 (PCSK9), angiopoietin-like protein (ANGPTLs), and fibroblast growth factors (FGFs), might play an important role in the regulation of dyslipidemia induced by hypothyroidism. Furthermore, under the status of hypothyroidism, significantly dysfunctional HDL particles could also be observed. In the current review, we summarized the recent knowledge of the relationship between the development of hypothyroidism with dyslipidemia. We also discussed the updated understanding of the mechanisms whereby hypothyroidism induces the risk and the development of dyslipidemia and cardio-metabolic diseases.
format	article
author	Xin Su Xiang Chen Hua Peng Jingjin Song Bin Wang Xijie Wu
author_facet	Xin Su Xiang Chen Hua Peng Jingjin Song Bin Wang Xijie Wu
author_sort	Xin Su
title	New insights into the pathological development of dyslipidemia in patients with hypothyroidism
title_short	New insights into the pathological development of dyslipidemia in patients with hypothyroidism
title_full	New insights into the pathological development of dyslipidemia in patients with hypothyroidism
title_fullStr	New insights into the pathological development of dyslipidemia in patients with hypothyroidism
title_full_unstemmed	New insights into the pathological development of dyslipidemia in patients with hypothyroidism
title_sort	new insights into the pathological development of dyslipidemia in patients with hypothyroidism
publisher	Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
publishDate	2021
url	https://doaj.org/article/26de6087423e4ea3aea214d0ec744e8e
work_keys_str_mv	AT xinsu newinsightsintothepathologicaldevelopmentofdyslipidemiainpatientswithhypothyroidism AT xiangchen newinsightsintothepathologicaldevelopmentofdyslipidemiainpatientswithhypothyroidism AT huapeng newinsightsintothepathologicaldevelopmentofdyslipidemiainpatientswithhypothyroidism AT jingjinsong newinsightsintothepathologicaldevelopmentofdyslipidemiainpatientswithhypothyroidism AT binwang newinsightsintothepathologicaldevelopmentofdyslipidemiainpatientswithhypothyroidism AT xijiewu newinsightsintothepathologicaldevelopmentofdyslipidemiainpatientswithhypothyroidism
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New insights into the pathological development of dyslipidemia in patients with hypothyroidism

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