Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity

Caenorhabditis elegans responds to mitochondrial stress by activating the mitochondrial unfolded protein response (UPRmt). Here the authors show that HDA-1, the C. elegans ortholog of mammalian histone deacetylase (HDAC), coordinates with the genome organizer DVE-1 to activate UPRmt and modulate mit...

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Autores principales:	Li-Wa Shao, Qi Peng, Mingyue Dong, Kaiyu Gao, Yumei Li, Yi Li, Chuan-Yun Li, Ying Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26de9ce408b94ac48ae0d0bb672b22eb
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id	oai:doaj.org-article:26de9ce408b94ac48ae0d0bb672b22eb
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spelling	oai:doaj.org-article:26de9ce408b94ac48ae0d0bb672b22eb2021-12-02T18:50:53ZHistone deacetylase HDA-1 modulates mitochondrial stress response and longevity10.1038/s41467-020-18501-w2041-1723https://doaj.org/article/26de9ce408b94ac48ae0d0bb672b22eb2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18501-whttps://doaj.org/toc/2041-1723Caenorhabditis elegans responds to mitochondrial stress by activating the mitochondrial unfolded protein response (UPRmt). Here the authors show that HDA-1, the C. elegans ortholog of mammalian histone deacetylase (HDAC), coordinates with the genome organizer DVE-1 to activate UPRmt and modulate mitochondrial homeostasis.Li-Wa ShaoQi PengMingyue DongKaiyu GaoYumei LiYi LiChuan-Yun LiYing LiuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li-Wa Shao Qi Peng Mingyue Dong Kaiyu Gao Yumei Li Yi Li Chuan-Yun Li Ying Liu Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity
description	Caenorhabditis elegans responds to mitochondrial stress by activating the mitochondrial unfolded protein response (UPRmt). Here the authors show that HDA-1, the C. elegans ortholog of mammalian histone deacetylase (HDAC), coordinates with the genome organizer DVE-1 to activate UPRmt and modulate mitochondrial homeostasis.
format	article
author	Li-Wa Shao Qi Peng Mingyue Dong Kaiyu Gao Yumei Li Yi Li Chuan-Yun Li Ying Liu
author_facet	Li-Wa Shao Qi Peng Mingyue Dong Kaiyu Gao Yumei Li Yi Li Chuan-Yun Li Ying Liu
author_sort	Li-Wa Shao
title	Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity
title_short	Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity
title_full	Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity
title_fullStr	Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity
title_full_unstemmed	Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity
title_sort	histone deacetylase hda-1 modulates mitochondrial stress response and longevity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/26de9ce408b94ac48ae0d0bb672b22eb
work_keys_str_mv	AT liwashao histonedeacetylasehda1modulatesmitochondrialstressresponseandlongevity AT qipeng histonedeacetylasehda1modulatesmitochondrialstressresponseandlongevity AT mingyuedong histonedeacetylasehda1modulatesmitochondrialstressresponseandlongevity AT kaiyugao histonedeacetylasehda1modulatesmitochondrialstressresponseandlongevity AT yumeili histonedeacetylasehda1modulatesmitochondrialstressresponseandlongevity AT yili histonedeacetylasehda1modulatesmitochondrialstressresponseandlongevity AT chuanyunli histonedeacetylasehda1modulatesmitochondrialstressresponseandlongevity AT yingliu histonedeacetylasehda1modulatesmitochondrialstressresponseandlongevity
_version_	1718377492034617344

Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity

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