Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties

The resin/gum of Boswellia species belonging to the family of Burseraceae is a naturally occurring mixture of bioactive compounds, which was traditionally used as a folk medicine to treat conditions like chronic inflammation. Several research studies have also explored its’ therapeutic potential aga...

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Autores principales:	Aisha Siddiqui, Zahoor Shah, Rao Nargis Jahan, Iekhsan Othman, Yatinesh Kumari
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Boswellic acids Neuroinflammation Inflammatory mediators Alzheimer’s disease Signalling pathways Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/26e1c76affb04df6a7d10154007cbf5f
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spelling	oai:doaj.org-article:26e1c76affb04df6a7d10154007cbf5f2021-11-14T04:28:50ZMechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties0753-332210.1016/j.biopha.2021.112250https://doaj.org/article/26e1c76affb04df6a7d10154007cbf5f2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010349https://doaj.org/toc/0753-3322The resin/gum of Boswellia species belonging to the family of Burseraceae is a naturally occurring mixture of bioactive compounds, which was traditionally used as a folk medicine to treat conditions like chronic inflammation. Several research studies have also explored its’ therapeutic potential against multiple neurodegenerative diseases such as Alzheimer’s disease (AD). The main chemical constituents of this gum include boswellic acids (BAs) like 3-O-acetyl-11-keto-β boswellic acid (AKBA) that possess potent anti-inflammatory and neuroprotective properties in AD. It is also involved in inhibiting the acetylcholinesterase (AChE) activity in the cholinergic pathway and improve choline levels as well as its binding with nicotinic receptors to produce anti-inflammatory effects. Multiple shreds of evidence have demonstrated that BAs modulate key molecular targets and signalling pathways like 5-lipoxygenase/cyclooxygenase, Nrf2, NF-kB, cholinergic, amyloid-beta (Aβ), and neurofibrillary tangles formation (NFTs) that are involved in AD progression. The present review focuses on the possible mechanistic therapeutic role of BAs in modulating the 5-LOX/COX pathway in arachidonic acid metabolism, activating Nrf2 through binding of ARE, inhibiting NF-kB and AChE activity. In addition, an inhibition of amyloid plaques (Aβ) and neurofibrillary tangles (NFTs) induced neurotoxicity and neuroinflammation in AD by BAs is also discussed in this review. We have also highlighted that BAs possess beneficial effects in AD by targeting multiple molecular pathways and makes it an emerging drug candidate for treating neurodegenerative diseases.Aisha SiddiquiZahoor ShahRao Nargis JahanIekhsan OthmanYatinesh KumariElsevierarticleBoswellic acidsNeuroinflammationInflammatory mediatorsAlzheimer’s diseaseSignalling pathwaysTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112250- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Boswellic acids Neuroinflammation Inflammatory mediators Alzheimer’s disease Signalling pathways Therapeutics. Pharmacology RM1-950
spellingShingle	Boswellic acids Neuroinflammation Inflammatory mediators Alzheimer’s disease Signalling pathways Therapeutics. Pharmacology RM1-950 Aisha Siddiqui Zahoor Shah Rao Nargis Jahan Iekhsan Othman Yatinesh Kumari Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
description	The resin/gum of Boswellia species belonging to the family of Burseraceae is a naturally occurring mixture of bioactive compounds, which was traditionally used as a folk medicine to treat conditions like chronic inflammation. Several research studies have also explored its’ therapeutic potential against multiple neurodegenerative diseases such as Alzheimer’s disease (AD). The main chemical constituents of this gum include boswellic acids (BAs) like 3-O-acetyl-11-keto-β boswellic acid (AKBA) that possess potent anti-inflammatory and neuroprotective properties in AD. It is also involved in inhibiting the acetylcholinesterase (AChE) activity in the cholinergic pathway and improve choline levels as well as its binding with nicotinic receptors to produce anti-inflammatory effects. Multiple shreds of evidence have demonstrated that BAs modulate key molecular targets and signalling pathways like 5-lipoxygenase/cyclooxygenase, Nrf2, NF-kB, cholinergic, amyloid-beta (Aβ), and neurofibrillary tangles formation (NFTs) that are involved in AD progression. The present review focuses on the possible mechanistic therapeutic role of BAs in modulating the 5-LOX/COX pathway in arachidonic acid metabolism, activating Nrf2 through binding of ARE, inhibiting NF-kB and AChE activity. In addition, an inhibition of amyloid plaques (Aβ) and neurofibrillary tangles (NFTs) induced neurotoxicity and neuroinflammation in AD by BAs is also discussed in this review. We have also highlighted that BAs possess beneficial effects in AD by targeting multiple molecular pathways and makes it an emerging drug candidate for treating neurodegenerative diseases.
format	article
author	Aisha Siddiqui Zahoor Shah Rao Nargis Jahan Iekhsan Othman Yatinesh Kumari
author_facet	Aisha Siddiqui Zahoor Shah Rao Nargis Jahan Iekhsan Othman Yatinesh Kumari
author_sort	Aisha Siddiqui
title	Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
title_short	Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
title_full	Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
title_fullStr	Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
title_full_unstemmed	Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
title_sort	mechanistic role of boswellic acids in alzheimer’s disease: emphasis on anti-inflammatory properties
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/26e1c76affb04df6a7d10154007cbf5f
work_keys_str_mv	AT aishasiddiqui mechanisticroleofboswellicacidsinalzheimersdiseaseemphasisonantiinflammatoryproperties AT zahoorshah mechanisticroleofboswellicacidsinalzheimersdiseaseemphasisonantiinflammatoryproperties AT raonargisjahan mechanisticroleofboswellicacidsinalzheimersdiseaseemphasisonantiinflammatoryproperties AT iekhsanothman mechanisticroleofboswellicacidsinalzheimersdiseaseemphasisonantiinflammatoryproperties AT yatineshkumari mechanisticroleofboswellicacidsinalzheimersdiseaseemphasisonantiinflammatoryproperties
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Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties

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