Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) shows a striking bias towards higher prevalence in females. Here, the authors perform fine-mapping of an SLE-associated locus at Xp21.2 and characterise a candidate gene, CXorf21, as IFN-responsive in immune cells that shows sexually dimorphic expression.

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Autores principales:	Christopher A. Odhams, Amy L. Roberts, Susan K. Vester, Carolina S. T. Duarte, Charlie T. Beales, Alexander J. Clarke, Sonja Lindinger, Samuel J. Daffern, Antonino Zito, Lingyan Chen, Leonardo L. Jones, Lora Boteva, David L. Morris, Kerrin S. Small, Michelle M. A. Fernando, Deborah S. Cunninghame Graham, Timothy J. Vyse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26e43468667241ccb8271a65e26175aa
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spelling	oai:doaj.org-article:26e43468667241ccb8271a65e26175aa2021-12-02T15:35:18ZInterferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus10.1038/s41467-019-10106-22041-1723https://doaj.org/article/26e43468667241ccb8271a65e26175aa2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10106-2https://doaj.org/toc/2041-1723Systemic lupus erythematosus (SLE) shows a striking bias towards higher prevalence in females. Here, the authors perform fine-mapping of an SLE-associated locus at Xp21.2 and characterise a candidate gene, CXorf21, as IFN-responsive in immune cells that shows sexually dimorphic expression.Christopher A. OdhamsAmy L. RobertsSusan K. VesterCarolina S. T. DuarteCharlie T. BealesAlexander J. ClarkeSonja LindingerSamuel J. DaffernAntonino ZitoLingyan ChenLeonardo L. JonesLora BotevaDavid L. MorrisKerrin S. SmallMichelle M. A. FernandoDeborah S. Cunninghame GrahamTimothy J. VyseNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher A. Odhams Amy L. Roberts Susan K. Vester Carolina S. T. Duarte Charlie T. Beales Alexander J. Clarke Sonja Lindinger Samuel J. Daffern Antonino Zito Lingyan Chen Leonardo L. Jones Lora Boteva David L. Morris Kerrin S. Small Michelle M. A. Fernando Deborah S. Cunninghame Graham Timothy J. Vyse Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus
description	Systemic lupus erythematosus (SLE) shows a striking bias towards higher prevalence in females. Here, the authors perform fine-mapping of an SLE-associated locus at Xp21.2 and characterise a candidate gene, CXorf21, as IFN-responsive in immune cells that shows sexually dimorphic expression.
format	article
author	Christopher A. Odhams Amy L. Roberts Susan K. Vester Carolina S. T. Duarte Charlie T. Beales Alexander J. Clarke Sonja Lindinger Samuel J. Daffern Antonino Zito Lingyan Chen Leonardo L. Jones Lora Boteva David L. Morris Kerrin S. Small Michelle M. A. Fernando Deborah S. Cunninghame Graham Timothy J. Vyse
author_facet	Christopher A. Odhams Amy L. Roberts Susan K. Vester Carolina S. T. Duarte Charlie T. Beales Alexander J. Clarke Sonja Lindinger Samuel J. Daffern Antonino Zito Lingyan Chen Leonardo L. Jones Lora Boteva David L. Morris Kerrin S. Small Michelle M. A. Fernando Deborah S. Cunninghame Graham Timothy J. Vyse
author_sort	Christopher A. Odhams
title	Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus
title_short	Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus
title_full	Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus
title_fullStr	Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus
title_full_unstemmed	Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus
title_sort	interferon inducible x-linked gene cxorf21 may contribute to sexual dimorphism in systemic lupus erythematosus
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/26e43468667241ccb8271a65e26175aa
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Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus

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