Brain in flames – animal models of psychosis: utility and limitations

Brain in flames – animal models of psychosis: utility and limitations

Daniele Mattei,1 Regina Schweibold,1,2 Susanne A Wolf1 1Department of Cellular Neuroscience, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany; 2Department of Neurosurgery, Helios Clinics, Berlin, Germany Abstract: The neurodevelopmental hypothesis of schizophrenia posits that...

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Autores principales: Mattei D, Schweibold R, Wolf SA
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/26e4ddb57d2745779d33cea4749f6309
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spelling oai:doaj.org-article:26e4ddb57d2745779d33cea4749f63092021-12-02T08:23:50ZBrain in flames – animal models of psychosis: utility and limitations1178-2021https://doaj.org/article/26e4ddb57d2745779d33cea4749f63092015-05-01T00:00:00Zhttp://www.dovepress.com/brain-in-flames-ndash-animal-models-of-psychosis-utility-and-limitatio-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Daniele Mattei,1 Regina Schweibold,1,2 Susanne A Wolf1 1Department of Cellular Neuroscience, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany; 2Department of Neurosurgery, Helios Clinics, Berlin, Germany Abstract: The neurodevelopmental hypothesis of schizophrenia posits that schizophrenia is a psychopathological condition resulting from aberrations in neurodevelopmental processes caused by a combination of environmental and genetic factors which proceed long before the onset of clinical symptoms. Many studies discuss an immunological component in the onset and progression of schizophrenia. We here review studies utilizing animal models of schizophrenia with manipulations of genetic, pharmacologic, and immunological origin. We focus on the immunological component to bridge the studies in terms of evaluation and treatment options of negative, positive, and cognitive symptoms. Throughout the review we link certain aspects of each model to the situation in human schizophrenic patients. In conclusion we suggest a combination of existing models to better represent the human situation. Moreover, we emphasize that animal models represent defined single or multiple symptoms or hallmarks of a given disease. Keywords: inflammation, schizophrenia, microglia, animal models Mattei DSchweibold RWolf SADove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 1313-1329 (2015)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Mattei D
Schweibold R
Wolf SA
Brain in flames – animal models of psychosis: utility and limitations
description Daniele Mattei,1 Regina Schweibold,1,2 Susanne A Wolf1 1Department of Cellular Neuroscience, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany; 2Department of Neurosurgery, Helios Clinics, Berlin, Germany Abstract: The neurodevelopmental hypothesis of schizophrenia posits that schizophrenia is a psychopathological condition resulting from aberrations in neurodevelopmental processes caused by a combination of environmental and genetic factors which proceed long before the onset of clinical symptoms. Many studies discuss an immunological component in the onset and progression of schizophrenia. We here review studies utilizing animal models of schizophrenia with manipulations of genetic, pharmacologic, and immunological origin. We focus on the immunological component to bridge the studies in terms of evaluation and treatment options of negative, positive, and cognitive symptoms. Throughout the review we link certain aspects of each model to the situation in human schizophrenic patients. In conclusion we suggest a combination of existing models to better represent the human situation. Moreover, we emphasize that animal models represent defined single or multiple symptoms or hallmarks of a given disease. Keywords: inflammation, schizophrenia, microglia, animal models 
format article
author Mattei D
Schweibold R
Wolf SA
author_facet Mattei D
Schweibold R
Wolf SA
author_sort Mattei D
title Brain in flames – animal models of psychosis: utility and limitations
title_short Brain in flames – animal models of psychosis: utility and limitations
title_full Brain in flames – animal models of psychosis: utility and limitations
title_fullStr Brain in flames – animal models of psychosis: utility and limitations
title_full_unstemmed Brain in flames – animal models of psychosis: utility and limitations
title_sort brain in flames – animal models of psychosis: utility and limitations
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/26e4ddb57d2745779d33cea4749f6309
work_keys_str_mv AT matteid braininflamesndashanimalmodelsofpsychosisutilityandlimitations
AT schweiboldr braininflamesndashanimalmodelsofpsychosisutilityandlimitations
AT wolfsa braininflamesndashanimalmodelsofpsychosisutilityandlimitations
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