PAX7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells

Abstract Background Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint (TMJ). Chronic TMD pain can be associated with genetic changes in the key muscle development genes. Objective To evaluate the...

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Autores principales:	Valquiria Quinelato, Letícia Ladeira Bonato, Alexandre Rezende Vieira, José Mauro Granjeiro, Karla Menezes, Radovan Borojevic, Priscila Ladeira Casado, Jose Albuquerque Calasans-Maia, Ricardo Tesch
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Chronic pain Temporomandibular joint dysfunction syndrome Myalgia Polymorphism genetic Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/26e7b9c3bfa54e99b18b46b4ff19ae9d
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spelling	oai:doaj.org-article:26e7b9c3bfa54e99b18b46b4ff19ae9d2021-11-21T12:27:36ZPAX7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells10.1186/s12891-021-04846-w1471-2474https://doaj.org/article/26e7b9c3bfa54e99b18b46b4ff19ae9d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12891-021-04846-whttps://doaj.org/toc/1471-2474Abstract Background Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint (TMJ). Chronic TMD pain can be associated with genetic changes in the key muscle development genes. Objective To evaluate the association between polymorphisms in the PAX7 (paired box 7) gene and masticatory myalgia in patients with temporomandibular disorders (TMD). Materials and methods This is a case-control study. Patients with TMD were divided into two groups: (a) presence of muscular TMD (n = 122) and (b) absence of muscular TMD (n = 49). Genomic DNA was obtained from saliva samples from all participants to allow for genotyping single nucleotide polymorphisms in PAX7 (rs766325 and rs6659735). Over-representation of alleles was tested using chi-square or Fisher’s exact tests. Values of p < 0.05 were considered to be statistically significant. Results Individuals without muscular TMD were less likely to have the PAX7 rs6659735 GG genotype (p = 0.03). No associations were found for PAX7 rs766325. Conclusions Alterations in PAX7 may influence muscular pathophysiology and individuals with TMD and the rs6659735 homozygous genotype (GG) are seemingly associated with muscular involvement of the disorder. No associations were found in the region rs766325.Valquiria QuinelatoLetícia Ladeira BonatoAlexandre Rezende VieiraJosé Mauro GranjeiroKarla MenezesRadovan BorojevicPriscila Ladeira CasadoJose Albuquerque Calasans-MaiaRicardo TeschBMCarticleChronic painTemporomandibular joint dysfunction syndromeMyalgiaPolymorphism geneticDiseases of the musculoskeletal systemRC925-935ENBMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic pain Temporomandibular joint dysfunction syndrome Myalgia Polymorphism genetic Diseases of the musculoskeletal system RC925-935
spellingShingle	Chronic pain Temporomandibular joint dysfunction syndrome Myalgia Polymorphism genetic Diseases of the musculoskeletal system RC925-935 Valquiria Quinelato Letícia Ladeira Bonato Alexandre Rezende Vieira José Mauro Granjeiro Karla Menezes Radovan Borojevic Priscila Ladeira Casado Jose Albuquerque Calasans-Maia Ricardo Tesch PAX7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells
description	Abstract Background Temporomandibular disorders (TMD) are a group of painful and debilitating disorders, involving the masticatory muscles and/or the temporomandibular joint (TMJ). Chronic TMD pain can be associated with genetic changes in the key muscle development genes. Objective To evaluate the association between polymorphisms in the PAX7 (paired box 7) gene and masticatory myalgia in patients with temporomandibular disorders (TMD). Materials and methods This is a case-control study. Patients with TMD were divided into two groups: (a) presence of muscular TMD (n = 122) and (b) absence of muscular TMD (n = 49). Genomic DNA was obtained from saliva samples from all participants to allow for genotyping single nucleotide polymorphisms in PAX7 (rs766325 and rs6659735). Over-representation of alleles was tested using chi-square or Fisher’s exact tests. Values of p < 0.05 were considered to be statistically significant. Results Individuals without muscular TMD were less likely to have the PAX7 rs6659735 GG genotype (p = 0.03). No associations were found for PAX7 rs766325. Conclusions Alterations in PAX7 may influence muscular pathophysiology and individuals with TMD and the rs6659735 homozygous genotype (GG) are seemingly associated with muscular involvement of the disorder. No associations were found in the region rs766325.
format	article
author	Valquiria Quinelato Letícia Ladeira Bonato Alexandre Rezende Vieira José Mauro Granjeiro Karla Menezes Radovan Borojevic Priscila Ladeira Casado Jose Albuquerque Calasans-Maia Ricardo Tesch
author_facet	Valquiria Quinelato Letícia Ladeira Bonato Alexandre Rezende Vieira José Mauro Granjeiro Karla Menezes Radovan Borojevic Priscila Ladeira Casado Jose Albuquerque Calasans-Maia Ricardo Tesch
author_sort	Valquiria Quinelato
title	PAX7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells
title_short	PAX7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells
title_full	PAX7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells
title_fullStr	PAX7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells
title_full_unstemmed	PAX7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells
title_sort	pax7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells
publisher	BMC
publishDate	2021
url	https://doaj.org/article/26e7b9c3bfa54e99b18b46b4ff19ae9d
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PAX7 gene polymorphism in muscular temporomandibular disorders as potentially related to muscle stem cells

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