Effect of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Receptor Antagonist Treatment on ACE2 Expression and SARS-CoV-2 Replication in Primary Airway Epithelial Cells
Rationale: SARS-CoV-2 gains entrance to airway epithelial cells (AECs) through binding of the viral spike protein to the angiotensin-converting enzyme 2 (ACE2) on the cell surface. However, ACE2 also converts angiotensin II into angiotensin-(1-7) and counterbalances the renin-angiotensin-aldosterone...
Enregistré dans:
Auteurs principaux: | Oghenemega Okoloko, Elizabeth R. Vanderwall, Lucille M. Rich, Maria P. White, Stephen R. Reeves, Whitney E. Harrington, Kaitlyn A. Barrow, Jason S. Debley |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Frontiers Media S.A.
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/26e83c257499441486daeccf5e446cf8 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
The role of renin-angiotensin system and angiotensin-converting enzyme 2 (ACE2) in the development and course of viral infection COVID-19 in patients with diabetes mellitus
par: O. K. Vikulova, et autres
Publié: (2020) -
Measurement of serum ACE status may potentially improve the diagnosis of SARS-CoV-2 infection
par: Gcinokwakhe D Ngcobo
Publié: (2021) -
Beneficial Effects of Angiotensin II AT1 Blocker on Cardiovascular Adverse Remodeling Due to Nitric Oxide Synthesis Blockade
par: Fernandes-Santos,Caroline, et autres
Publié: (2006) -
Association between angiotensinogen (AGT), angiotensin-converting enzyme (ACE) and angiotensin-II receptor 1 (AGTR1) polymorphisms and COVID-19 infection in the southeast of Iran: a preliminary case-control study
par: Hamid Reza Kouhpayeh, et autres
Publié: (2021) -
Relationship between the expression of angiotensin II receptors type 1 and vasoactive regulators in arterial hypertension
par: Anna V. Logatkina, et autres
Publié: (2020)